A novel vitamin D3 analog, 22-oxa-1, 25-dihydroxyvitamin D3, inhibits the growth of human breast cancer in vitro and in vivo without causing hypercalcemia

Endocrinology

Volumn 129, Issue 2, 1991, Pages 832-837

  Abe, Junko ^a   Nakano, Toshiaki ^a   Nishii, Yasuho ^a   Matsumoto, Toshio ^b   Ogata, Etsuro ^b   Ikeda, Kyoji ^b  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,25 DIHYDROXY 22 OXAVITAMIN D3; 1,25-DIHYDROXY-22-OXAVITAMIN D3; CALCITRIOL; CALCIUM; DOXORUBICIN; DRUG DERIVATIVE; ESTROGEN RECEPTOR; SERUM ALBUMIN; 22 OXACALCITRIOL;

ANIMAL; ARTICLE; BLOOD; BREAST TUMOR; CANCER TRANSPLANTATION; CELL CULTURE; CELL DIFFERENTIATION; CELL DIVISION; DRUG EFFECT; HUMAN; HYPERCALCEMIA; IATROGENIC DISEASE; KINETICS; METABOLISM; MOUSE; NUDE MOUSE; PATHOLOGY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BREAST CANCER; CELL GROWTH; CONTROLLED STUDY; FEMALE; HUMAN CELL; INTRATUMORAL DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ANIMAL; BREAST NEOPLASMS; CALCITRIOL; CALCIUM; CELL DIFFERENTIATION; CELL DIVISION; DOXORUBICIN; HUMAN; HYPERCALCEMIA; KINETICS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; RECEPTORS, ESTROGEN; SERUM ALBUMIN; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0025925343     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/endo-129-2-832     Document Type: Article

References (27)

1. Haussler MR, McCain TA 1977 Basic and clinical concepts related to vitamin D metabolism and action. N Engl J Med 297:974-983, 1041-1050
2. Norman AW, Roth J, Orci L 1982 The vitamin D endocrine system: Steroid metabolism, hormone receptors, and biological response (calcium binding proteins). Endocr Rev 3:331-366
3. DeLuca HF 1983 Vitamin D: Recent advances. Annu Rev Biochem 52:411-439
4. Reichel H, Koeffler HP, Norman AW 1989 The role of the vitamin D endocrine system in health and disease. N Engl J Med 320:980-991
5. 3. Proc Natl Acad Sci USA 78:4990-4994
6. 3prolong survival time of mice inoculated with myeloid leukemia cells. Proc Natl Acad Sci USA 80:201-204
7. Eisman JA, Martin TJ, Maclntyre I, Moseley JM 1979 1, 25-Dihydroxyvitamin D receptor in breast cancer cells. Lancet 2:1335-1336
8. Frampton RJ, Omond SA, Eisman JA 1983 Inhibition of human cancer cell growth by 1, 25-dihydroxyvitamin D3 metabolites. Cancer Res 43:4443-4447
9. Eisman JA, Barkla DH, Tutton PJM 1987 Suppression of in vivo growth of human cancer solid tumor xenografts by 1, 25-dihydroxy-vitamin D3. Cancer Res 47:21-25
10. Colston KW, Berger U, Coombes RC 1989 Possible role for vitamin D in controlling breast cancer cell proliferation. Lancet 1:188-191
11. 3: Preferential activity in inducing differentiation of human leukemia cells HL-60 in vitro. Proc Natl Acad Sci USA 84:89-95
12. 3prolongs survival time of leukemic mice. Proc Natl Acad Sci USA 87:3929-3932
13. 3analogues. Chem Pharmacol Bull 34:2286-2289
14. Murayama E, Miyamoto K, Kubodera N, Mori T, Matsunaga I 1986 Synthetic studies of vitamin D analogues. VIII. Synthesis of 22-oxavitamin D3 analogues. Chem Pharmacol Bull 34:4410-4413
15. 3with an oxygen atom in the side chain skeleton. FEBS Lett 226:58-62
16. 3, is a potent modulator of in vivo immunoregulating activity without inducing hypercalcemia in mice. Endocrinology 124:2645-2647
17. 3: 22-oxa-1α, 25-dihydroxyvitamin D3. J Nutr Sci Vitaminol 36:21-31
18. Ovejera AA, Houchens DP, Barker AD 1978 Chemotherapy of human tumor xenografts in genetically athymic mice. Ann Clin Lab Sci 8:50-56
19. 3a synthetic analogue of 1α, 25-dihydroxyvitamin D3. J Nutr Sci Vitaminol 35:529-533
20. Sher E, Eisman JA, Moseley JM, Martin TJ 1981 Whole-cell uptake and nuclear localization of 1, 25-dihydroxycholecalciferol by breast cancer cells (T47 D) in culture. Biochem J 200:315-320
21. Brown AJ, Ritter CR, Finch JL, Morrissey J, Martin KJ, Murayama E, Nishii Y, Slatopolsky E 1989 The noncalcemic analogue of vitamin D, 22-oxacalcitriol, suppresses parathyroid hormone synthesis and secretion. J Clin Invest 84:728-732
22. 3fully induce the human osteocalcin gene promoter in stably transfected rat osteosarcoma cells (ROSCO-2). 12th Annual Meeting of the American Society for Bone and Mineral Research, Atlanta GA, 1990, p S143 (Abstract)
23. 3analogues. Eur J Pharmacol 178:247-250
24. Lippman ME, Bolan G 1975 Oestrogen-responsive human breast cancer in long term tissue culture. Nature (Lond) 256:592-593
25. Santen RJ, Manni A, Harvey H, Redmond C 1990 Endocrine treatment of breast cancer in women. Endocr Rev 11:221-265
26. Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL 1987 Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235:177-182
27. Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE, Levin WJ, Stuart SG, Udove J, Ullrich A, Press MF 1989 Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244:707-712