19F nuclear magnetic resonance analysis of trifluoroethanol metabolites in the urine of the Sprague-Dawley rat

Biochemical Pharmacology

Volumn 42, Issue 11, 1991, Pages 2229-2238

  Selinsky, Barry S ^a   Rusyniak, Daniel E ^a   Warsheski, Joseph O ^a   Joseph, A P ^b  

^a VILLANOVA UNIVERSITY   (United States)

^b Otsuka Electronics USA ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; TRIFLUOROACETALDEHYDE; TRIFLUOROACETIC ACID; TRIFLUOROETHANOL; UNCLASSIFIED DRUG; ACETALDEHYDE; DRUG DERIVATIVE; FLUORINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GLUCURONIDATION; MALE; METABOLITE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT; URINE LEVEL; XENOBIOTIC METABOLISM; ANIMAL; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT STRAIN; TIME; URINE;

ACETALDEHYDE; ANIMAL; ETHANOL; FLUORINE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; RATS; RATS, INBRED STRAINS; SUPPORT, NON-U.S. GOV'T; TIME FACTORS; TRIFLUOROACETIC ACID; TRIFLUOROETHANOL;

EID: 0025925168     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(91)90360-H     Document Type: Article

References (24)

1. Role of biotransfonnation in the toxicity of inhalation anesthetics
2. Pharmacology and toxicology of halogenated anesthetics
3. Role of hepatic microsomal cytochrome P-450 in the toxicity of fluorinated ether anesthetics
4. Urinary metabolites of halothane in man
5. Animal toxicity of 2,2,2-trifluoroethanol
6. Idanpaan-Heikkila JE and Walker K, Distribution and fate of trifluoroethanol in rats
7. Metabolism of 2,2,2-trifluoroethanol and its relationship to toxicity
8. 2,2,2-Trifluoroethanol intestinal and bone marrow toxicity: The role of its metabolism to 2,2,2-trifluoroacetaldehyde and trifluoroacetic acid
9. Modification of liver microsomal lipids by halothane metabolites; a multi nuclear NMR spectroscopic study
10. 19F NMR spectroscopy
11. In vivo nuclear magnetic resonance studies of hepatic methoxyflurane metabolism. I. Verification and quantitation of methoxydifluoroacetate
12. In vivo nuclear magnetic resonance studies of hepatic methoxyflurane metabolism. II. A reevaluation of hepatic metabolic pathways
13. Multiple aspects of the toxicity of fluroxene and its metabolite 2,2,2-trifluoroethanol
14. Metabolic effects of alcohol
15. A possible mechanism of toxicity of trifluoroethanol and other halothane metabolites
16. Anesthesia LXXIV. Biotransformation of fluroxene—I. Metabolism in mice and dogs in vivo
17. NMR spectroscopy of body fluids
18. 19F-NMR study of halothane distribution in brain
19. Fluroxene (2,2,2-trifluoroethyl vinyl ether) mediated destruction of cytochrome P-450 in vitro
20. The interaction of hepatic microsomal cytochrome P-450 with fluroxene (2,2,2-trifluoroethyl vinyl ether) in vitro
21. Destruction of highly purified cytochromes P-450 associated with metabolism of fluorinated ether anesthetics
22. Ethanol-, fasting-, and acetone-inducible cytochromes P-450 in rat liver: Regulation and characteristics of enzymes belonging to the IIB and II gene subfamilies
23. Ethanol increases cytochromes P450IIE, IIB1/2, and IIA in cultured rat hepatocytes