O6-Alkylguanine-DNA Alkyltransferase Depletion and Regeneration in Human Peripheral Lymphocytes following Dacarbazine and Fotemustine

Cancer Research

Volumn 51, Issue 2, 1991, Pages 619-623

  Margison, G P ^b,c   Thatcher, N ^a  

^a Whittington Health   (United Kingdom)

^b Christie Hospital ^*  (United Kingdom)

^c CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ANTINEOPLASTIC AGENT; DACARBAZINE; FOTEMUSTINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METHYLTRANSFERASE; NITROSOUREA DERIVATIVE; O(6) METHYLGUANINE DNA METHYLTRANSFERASE; ORGANOPHOSPHORUS COMPOUND; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE;

ADULT; AGED; ARTICLE; DRUG EFFECT; ENZYMOLOGY; FEMALE; HUMAN; KINETICS; LYMPHOCYTE; MALE; MELANOMA; METABOLISM; CANCER CHEMOTHERAPY; CLINICAL ARTICLE; ENZYME ACTIVITY; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; PRIORITY JOURNAL;

ADENOSINETRIPHOSPHATASE; ADULT; AGED; ANTINEOPLASTIC AGENTS; DACARBAZINE; FEMALE; HUMAN; KINETICS; LYMPHOCYTES; MALE; MELANOMA; METHYLTRANSFERASES; MIDDLE AGE; NITROSOUREA COMPOUNDS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; ORGANOPHOSPHORUS COMPOUNDS; SUPPORT, NON-U.S. GOV'T;

EID: 0025924721     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Day, R. S., Babich, M. A., Yarosh, D. B., and Scudiero, D. A. The role of 0-methylguanine in human cell killing, sister chromatid exchange induction and mutagenesis. J. Cell. Sci. Suppl. 6, 333-353, 1987.
2. D'lncalci, M., Citti, L., Taverna, P., and Catapano, C. V. Importance of DNA repair enzyme 06-alkyl guanine alkyltransferase (AT) in cancer chemotherapy. Cancer Treat. Rev., 15: 279-292, 1988.
3. Day, R. S., III, Ziolkowski, C. H. J., Scudiero, D. A., Meyer, S. A., Lubiniecki, A. S., Girardi, A. J., Galloway, S. M., and Bynum, G. D. Defective repair of alkylated DNA by human tumour on SV40 transformed human cell strains. Nature (Lond.), 288: 724-727, 1980.
4. Gerson, S. L., Trey, J. E., and Miller, K. Potentiation of nitrosourea cytotoxicity in human leukemic cells by inactivation of 06-alkylguanine-DNA alkyltransferase. Cancer Res., 48: 1521-1527, 1988.
5. Dolan, M. E., Corsico, C. D., and Pegg, A. E. Exposure of HeLa cells to 06-alkylguanine increases sensitivity to the cytotoxic effects of alkylating agents. Biochem. Biophys. Res. Commun., 132: 178-185, 1985.
6. Yarosh, D. B., Hurst-Calderone, S., Babich, M. A., and Day, R. S., III. Inactivation of 06-methylguanine-DNA methyltransferase and sensitization of human tumour cells to killing by chloroethylnitrosourea by 06-methyl-guanine as a free base. Cancer Res., 46: 1663-1668, 1986.
7. Zlotogorski, C., and Erickson, L. C. Pretreatment of human colon tumour cells with DNA methylating agents inhibit their ability to repair chloroethyl monoadducts. Carcinogenesis (Lond.), 5: 83-87, 1984.
8. Zlotogorski, C., and Erickson, L. C. Pretreatment of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylnitrosourea to produce DNA interstrand cross-links not observed in cells treated with chloroethylnitrosourea alone. Carcinogenesis (Lond.), 4: 759-763, 1983.
9. Gibson, N. WM Hartley, J. A., Barnes, D., and Erickson, L. C. Combined effects of streptozotocin and mitozolomide against four human cell lines of the Mer phenotype. Cancer Res., 46:4995-4998, 1986.
10. Tong, W. P., Kirk, M. C., and Ludlum, D. B. Formation of the crosslink 1-(/VdeoxycytidylJ-l/V'-deoxyguanosinylJethane in DNA treated with N,N-bis(chloroethyl)-N-nitrosourea. Cancer Res., 42: 3102-3105, 1982.
11. Fujio, C., Chang, H. R., Tsujimura, T., Ishizaki, K., Kitamur, H., and Ikenaga, M. Hypersensitivity of human tumor xenografts lacking 06-alkyl-guanine-DNA-alkyltransferase to the anti-tumor agent l-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea. Carcinogenesis (Lond.), 10: 351-356, 1989.
12. White, G. R. M., Ockey, C. H., Brennand, J., and Margison, G. P. Chinese hamster cells harbouring the E. coli 06-alkylguanine alkyltransferase gene are less susceptible to SCE induction and chromosome damage by methylating agents. Carcinogenesis (Lond.), 7: 2077-2080, 1986.
13. Samson, L., Derfler, B., and Waldstein, E. A. Expression of human alkylation repair defects by Escherichia coli DNA repair genes. Proc. Natl. Acad. Sci. USA, 83: 5607-5610, 1986.
14. Jelinek, J., Kleibl, K., Dexter, T. M., and Margison, G. P. Transfection of murine multi-potent haemopoietic stem cells with an E. coli DNA alkyltransferase gene confers resistance to the toxic effects of alkylating agents. Carcinogenesis (Lond.), 9: 81-87, 1988.
15. Dolan, M. E., Norbeck, L., Clyde, C., Hora, N. K., Erickson, L. C., and Pegg, A. L. Expression of mammalian E>6-alkylguanine DNA alkyltransferase in a cell line sensitive to alkylating agents. Carcinogenesis (Lond.), 10:1613-1619, 1989.
16. Lunn, J. M., and Harris, A. L. Cytotoxicity of 5-(3-methyl-l-tri-azeno)imidazole-4-carboxamide (MTIC) on Mer\ Mer+, Rem, and Mer-cell lines: differential potentiation by 3-acetamidobenzamide. Br. J. Cancer, 57: 54-58, 1988.
17. Gibson, N. W., Hartley, J., La-France, R. J., and Vaughan, K. Differential cytotoxicity and DNA-damaging effects produced in human cells of the Mer and Mer phenotypes by a series of alkyltriazenylimidazoles. Carcinogenesis (Lond.), 7:259-265, 1986.
18. Catapano, C. V., Broggini, M., Erba, E., Ponti, M., Mariani, L., Citti, L., and D'lncalci, M. In vitro and in vivo methazolostone-induced DNA damage and repair in LI210 leukemia sensitive and resistant to chloroethylnitrosou-reas. Cancer Res., 47:4884-4889, 1987.
19. Foster, B. J., Newell, D. R., Lunn, J. M., Jones, M., and Calvert, A. H. Correlation of dacarbazine and CB10-277 activity against human melanoma xenografts with 06-alkyltransferase. Proc. Am. Assoc. Cancer Res., 31:401, 1990.
20. Aamdal, S., Radford, J., Thatcher, N., D'lncalci, M., and Gerard, B. Phase II trial of the sequential administration of DTIC and fotemustine in advanced malignant melanoma. Proc. Am. Assoc. Cancer Res., 31: 200, 1990.
21. Filippeschi, S., Colombo, T., Bassani, D., De-Francesco, L., Arioli, P., D'lncalci, M., Bartosek, I., and Guaitani, A. Antitumour activity of the novel nitrosourea S10036 in rodent tumours. Anticancer Res., 8: 1351-1354, 1988.
22. Jacquillat, C., Khayat, D., Banzet, P., Weil, M., Fumoleau, P., Avril, M. F., Namer, M., Bonneterre, J., Kerbrat, P., Bonerandi, J. J., et al. Final report of the phase II study of the nitrosourea fotemustine (S 10036) in 153 patients with disseminated malignant melanoma (DMM) including brain metastases. Proc. Am. Assoc. Cancer Res., 30: 41088, 1989.
23. SafThill, R., Margison, G. P., and O'Connor, P. J. Mechanisms of carcinogenesis induced by alkylating agents. Biochim. Biophys. Acta, 823: 111-145, 1985.
24. Morten, J. E. N., and Margison, G. P. Increased 06-alkylguanine alkyltransferase activity in Chinese hamster V79 cells following selection with chloroethylating agents. Carcinogenesis (Lond.), 9: 45-49, 1988.
25. Gerson, S. L. Modulation of human lymphocyte 06-alkylguanine DNA alkyltransferase by streptozotocin in vivo. Cancer Res., 49:3134-3138,1989.
26. Kyrtopoulos, S. A., Ampatzi, P., Davaris, P., Haritopoulos, N., and Gole-matis, B. Studies in gastric carcinogenesis. IV. 06-Methylguanine and its repair in normal and atrophic biopsy specimens of human gastric mucosa. Correlation of 06-alkylguanine-DNA alkyltransferase activities in gastric mucosa and circulating lymphocytes. Carcinogenesis (Lond.), 11: 431-436, 1990.
27. Fong, L. Y. Y., Jensen, D. E., and Magee, P. N. DNA methyl-adduct dosimetry and 06-alkylguanine-DNA alkyl transferase activity determinations in rat mammary carcinogenesis by procarbazine and N-methylnitrosou-rea. Carcinogenesis (Lond.), //: 411-417, 1990.
28. Kleihues, P., Kolar, G. F., and Margison, G. P. Interaction of the carcinogen 3,3-dimethyl-1-phenyltriazene with nucleic acids of various rat tissues and the effect of a protein-free diet. Cancer Res., 36: 2189-2193, 1976.
29. Connors, T. A., Goddard, P. M., Merai, K., Ross, W. C. J., and William, D. E. V. Tumour inhibitor}’ triazenes: structural requirements for an active metabolite. Biochem. Pharmacol., 25: 241-246, 1976.
30. Balch, C. M., Houghton, A., and Peters, L. Cutaneous melanoma. In: V. T. DeVita, S. Heilman, and S. A. Rosenberg (eds.), Cancer: Principles and Practice of Oncology, pp. 1499-1542. Philadelphia: J. B. Lippincott Co., 1989.
31. Maynard, K., Parsons, P. G., Cerny, T., and Margison, G. P. Relationships among cell survival, 6>6-alkylguanine-DNA alkyltransferase activity, and reactivation of methylated adenovirus 5 and herpes simplex virus type 1 in human melanoma cell lines. Cancer Res., 49: 4813-4817, 1989.
32. Clark, P. C. The evolution of therapy for malignant melanoma at the University of Texas M. D. Anderson Hospital and Tumour Institute 1950 to 1975. Pigm. Cell, 2: 365-378, 1976.
33. Parsons, P. G., Smellie, S. G., Morrison, L. E., and Hayward, I. P. Properties of human melanoma cells resistant to 5-(3'-3'-dimethyl-1-tri-azeno)imidazole-4-carboxamide and other methylating agents. Cancer Res., 42: 1454-1461, 1982.
34. Hayward, I. P., and Parsons, P. G. Comparison of virus reactivation, DNA base damage, and cell cycle effects in autologous melanoma cells resistant to methylating agents. Cancer Res., 44: 55-58, 1984.