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Volumn 88, Issue 16, 1991, Pages 7371-7375
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Glu-192 → Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin
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Author keywords
mutagenesis; protein engineering; serine proteinases; structure activity relationship; substrate specificity
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Indexed keywords
SERINE PROTEINASE;
THROMBIN;
THROMBOMODULIN;
CELL SURFACE RECEPTOR;
GLUTAMIC ACID;
GLUTAMIC ACID DERIVATIVE;
GLUTAMINE;
PROTHROMBIN;
RECOMBINANT PROTEIN;
THROMBIN RECEPTOR;
TRYPSIN;
ARTICLE;
HUMAN;
PRIORITY JOURNAL;
STRUCTURE ACTIVITY RELATION;
AMINO ACID SEQUENCE;
ANIMAL;
CATTLE;
ENZYME SPECIFICITY;
GENETICS;
KINETICS;
METABOLISM;
MOLECULAR GENETICS;
RABBIT;
SITE DIRECTED MUTAGENESIS;
AMINO ACID SEQUENCE;
ANIMAL;
CATTLE;
GLUTAMATES;
GLUTAMIC ACID;
GLUTAMINE;
HUMAN;
KINETICS;
MOLECULAR SEQUENCE DATA;
MUTAGENESIS, SITE-DIRECTED;
PROTHROMBIN;
RABBITS;
RECEPTORS, CELL SURFACE;
RECEPTORS, THROMBIN;
RECOMBINANT PROTEINS;
SUBSTRATE SPECIFICITY;
SUPPORT, NON-U.S. GOV'T;
SUPPORT, U.S. GOV'T, P.H.S.;
THROMBIN;
TRYPSIN;
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EID: 0025923430
PISSN: 00278424
EISSN: None
Source Type: Journal
DOI: 10.1073/pnas.88.16.7371 Document Type: Article |
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Times cited : (147)
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References (0)
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