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Current Opinion in Immunology
Volumn 3, Issue 5, 1991, Pages 748-751
Cyclosporine, FK506 and other drugs in organ transplantation
Author keywords

[No Author keywords available]
Indexed keywords

15 DEOXYSPERGUALIN; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NEW DRUG; RAPAMYCIN; TACROLIMUS; DRUG DERIVATIVE; GUANIDINE DERIVATIVE; MYCOPHENOLIC ACID; POLYENE; TSUKUBAENOLIDE;
EID: 0025917840     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/0952-7915(91)90107-C     Document Type: Article
Times cited : (33)
References (21)
  • 1
    • 0025968957 scopus 로고
    • The Changing Pattern of Post-transplant Malignancies
    • of interest, An interesting overview of the incidence of cancer in organ transplant recipients from the Cincinatti Transplant Tumor Registry.
    • (1991) Transplant Proc , vol.23 , pp. 1101-1103
    • Penn1
  • 2
    • 0025897393 scopus 로고
    • Immunosuppression in Renal Transplantation. 1. Cyclosporine and Azathioprine
    • of interest, An excellent current review of the clinical use of these two drugs in the prevention and treatment of graft rejection.
    • (1991) Clin Transplantation , vol.5 , pp. 65-85
    • Gruber1    Chan2    Canafax3    Matas4
  • 3
    • 0026030793 scopus 로고
    • Beneficial Effects of Prophylactic OKT3 in Cadaver Kidney Transplan tation: Comparison with Cyclosporine A in a Single-Center Prospective Randomised Study
    • of interest, A prospective randomized study of sequential therapy with OKT3 versus triple therapy, showing graft survival of over 90% at 1 year in the former compared to around 80% in the latter.
    • (1991) Transplantation Proc , vol.23 , pp. 1046-1047
    • Goldman1    Abramowicz2    De Paula3    Mareaux4    Vanderwinden5    Kinnaert6    Vereerstraeten7
  • 4
    • 85025340034 scopus 로고
    • Cyclosporine-induced renal dysfunction in experimental animals and humans
    • of interest, A thorough review of this major complication of cyclosporine therapy.
    • (1991) Transplantation Reviews , vol.5 , pp. 63-70
    • Perico1    Remizzu2
  • 5
    • 0026071093 scopus 로고
    • A Retrospective Analysis of Late Renal Graft Function: Correlation with Mean Cyclosporine Levels and Lack of Evidence for Chronic Cyclosporine Toxicity
    • of interest, An intriguing retrospective study of patients with kidney transplants suggesting that poor long-term renal function is associated with low cyclosporine blood levels, and thus may be a result of chronic rejection rather than cyclosporine nephrotoxicity. The results of prospective studies that are in progress are awaited with interest.
    • (1991) Transplantation Proc , vol.23 , pp. 1018-1019
    • Salomon1    Brunson2    Vansickier3    Pfaff4    Howard5    Peterson6    Curry7    Thompson8    Squires9
  • 6
    • 0024814684 scopus 로고
    • Immunosuppressive drugs
    • of interest, An earlier review in a series describing FK506, rapamycin, mizoribine, RS-6144, and 15-deoxyspergualin.
    • (1990) Current Opinion in Immunology , vol.2 , pp. 854-858
    • St Collier1
  • 7
    • 0025962242 scopus 로고
    • FK506: an Inlmunosuppressant for the 1990s
    • of interest, A short but thorough review of the mechanisms of action, toxicity and clinical use of FK506 in man.
    • (1991) Lancet , vol.337 , pp. 25-27
    • McCleod1    Thomson2
  • 8
    • 0026093037 scopus 로고
    • FK506: Short and Long Term Treatment after Cardiac Transplantation in Non-Human Primates
    • of interest, Heterotopic cardiac transplants were performed in chacma baboons given FK506 for 14 days or continuously. Both short term and continuous therapy produced long-term survival. After stopping FK506, acute rejection occurred after 20 days, but reintroduction of the drug led to reversal of the rejection episode.
    • (1991) Transplantation Proc , vol.23 , pp. 509-510
    • Hillebrandt1    Meiser2    Human3    Reichenspurner4    Rose5    Odell6    Reichakt7
  • 9
    • 0025635897 scopus 로고
    • The Cytosofic-Binding Protein for the Immunosuppressant FK506 is Both a Ubiquitous and Highly Conserved Peptidyl-Prolyl Cis-transIsomerase
    • of outstanding interest, FKBP is not a lymphoid-specific protein but is widely distributed and phylogenetically conserved, suggesting an important biological role for this protein in all eukaryotic cells.
    • (1990) J Biol Chem , vol.265 , pp. 2101-2105
    • Siekierka1    Wiederecht2    Grenlich3    Boulton4    Hung5    Cryan6    Hodges7    Sigal8
  • 10
    • 0026068924 scopus 로고
    • Selected Topics on FK506, with Special Reference to Rescue of Extrahepatic Whole Organ Grafts, Transplantation of ‘Forbidden Organs’, Side Effects, Mechanisms and Practical Pharmacokinetics
    • of interest, The highlights of the initial Pittsburgh experience with FK506.
    • (1991) Transplantation Proc , vol.23 , pp. 914-919
    • Starzl1    Abu Elmagar2    Tzakis3    Fung4    Porter5    Todo6
  • 11
    • 0025971185 scopus 로고
    • Conversion of Liver Allograft Recipients from Cyclosporine to FK506-Based Immunosuppression: Benefits and Pitfalls
    • of outstanding interest, Documents impressive results after conversion of patients with failing liver transplants to FK506, 70% of these being in the presence of rejection refractory to treatment with OKT3.
    • (1991) Transplantation Proc , vol.23 , pp. 14-21
    • Fung1    Todo2    Tzakis3    Demetris4    Jain5    Abu-Elmagd6    Alessiani7    Starzl8
  • 12
    • 0026085612 scopus 로고
    • Kidney Transplantations under FK506 Immunosuppression
    • of interest, In a fairly typical group of 65 patients receiving 66 kidney transplants and treated with FK506 and steroids, the early results are unremarkable: 27% of the patients needed OKT3 treatment. However, of 52 patients with functioning grafts, steroids were discontinued in 60%. Randomized prospective trials are required.
    • (1991) Transplantation Proc , vol.23 , pp. 920-923
    • Shapiro1    Jordan2    Fung3    McCauley4    Johnston5    Iwaki6    Tzakis7    Hakaia8    Todo9    Starzl10
  • 14
    • 0026063950 scopus 로고
    • Use Of Rapamycin for the Suppression of Alloimmune Reactions In Vivo: Schedule Dependence, Tolerance Induction, Synergy with Cyclosporine and FK506, and Effect on Host-VersusGraft and Graft-Versus-Host Reactions
    • of interest, A useful summary of the in vivo immunosuppressive properties of rapamycin.
    • (1991) Transplantation Proc , vol.23 , pp. 521-524
    • Morris1    Meiser2    Wu3    Shorthouse4    Wang5
  • 15
    • 0025647885 scopus 로고
    • Two Distinct Signal Transmission Pathways in T Lymphocytes are Inhibited by Complexes Formed Between an Immunophilin and Either FK506 or Rapamycin
    • of outstanding interest, Although both rapamycin and FK506 are of a similar molecular structure and both bind to the same, or a closely adjoining, receptor on the FKBP, their different immunosuppressive properties suggest that the immunophilin drug complex affects different signal transduction pathways.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 9231-9235
    • Bierer1    Mattila2    Standaert3    Herzenberg4    Burakoff5    Grabtree6    Schreiber7
  • 16
    • 0026031552 scopus 로고
    • Comparison of the Immunosuppressive Effects of Mycophenolic and the Morpholinoethyl Ester of Mycophenolic Acid (RS-61443) in Recipients of Heart AIlografts
    • of outstanding interest, An interesting comparison of the effect of RS and mycophenolic acid, to which the former is hydrolyzed, in a rat cardiac allograft model.
    • (1991) Transplantation Proc , vol.23 , pp. 493-496
    • Morris1    Wang2
  • 18
    • 0025981270 scopus 로고
    • RS-61443 — a New Potent Immunosuppressive Agent
    • of outstanding interest, In a kidney allograft model in the dog, RS used alone prolonged graft survival to a median of 36 days but when combined with low dose cyclosporine (5mg/kg) and steroids, median graft survival was 122 days.
    • (1991) Transplantation , vol.51 , pp. 27-31
    • Platz1    Sollinger2    Hullett3    Eckhoff4    Eugin5    Allison6
  • 19
    • 0025904848 scopus 로고
    • Deoxyspergualin in Lethal Murine Graft-Versus-Host Disease
    • of interest, Deoxyspergualin was able to suppress GVH disease in this model of lethal GVH disease (bone marrow and spleen cells from C457BI/6 mice to lethally irradiated CBA mice) with long-term survivors being stable chimaeras. The concomitant administration of methotrexate enhanced the suppression of GVH disease more than the use of either agent alone.
    • (1991) Transplantation , vol.51 , pp. 712-715
    • Nemoto1    Hayashi2    Ito3    Sugawara4    Mae5    Fugii6    Abe7    Fujii8    Tachenchi9
  • 20
    • 0025979981 scopus 로고
    • Inhibition of Antibody Production by the Immunosuppressive Agent, 15-Deoxyspergualin
    • of interest, 15-deoxyspergualin completely ablates the primary response to sheep red blood cells in mice as well as the response to the soluble protein keyhole limpet haemocyuiin (KLH). However, memory of KLH in a primed recipient is only inhibited to a modest extent by the drug.
    • (1991) Transplantation Proc , vol.23 , pp. 328-331
    • Tepper1    Petty2    Bursuker3    Pasternak4    Cleaveland5    Spitasny6    Schacter7
  • 21
    • 0026030803 scopus 로고
    • Prophylactic Use of a New Immunosuppressive Agent, Deoxyspergualin, in Patients with Kidney Transplantation from ABO-Incompatible or Preformed Antibody Positive Donors
    • of interest, Deoxyspergualin has been used as one of the immunosuppressive agents in a very heavy immunosuppressive protocol in these high risk recipients of living related renal transplants. Recipients were plasmapheresed before transplantation and in addition to deoxyspergualin received cyclosporine, azathioprine, steroids and ALG after transplantation at which time splenectomy was also performed. Nevertheless the results are impressive in that only one of eighteen grafts was lost from rejection, but it is not possible to evaluate the role of deoxyspergualin in these results.
    • (1991) Transplantation Proc , vol.23 , pp. 1078-1082
    • Takahashi1    Tanabe2    Ooba3    Yagisawa4    Nakazawa5    Teraoka6    Hayasaka7    Kawaguchi8    Ito9    Toma10

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.