Central Nervous System Side Effects of Nonsteroidal Anti-inflammatory Drugs: Aseptic Meningitis, Psychosis, and Cognitive Dysfunction

Archives of Internal Medicine

Volumn 151, Issue 7, 1991, Pages 1309-1313

  Hoppmann, Richard A ^a,b   Peden, James G ^a   Ober, Scott K ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

^b UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; IBUPROFEN; INDOMETACIN; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; SULINDAC; TOLMETIN;

ADVERSE DRUG REACTION; AGE; AMNESIA; ASEPTIC MENINGITIS; CENTRAL NERVOUS SYSTEM DISEASE; COGNITIVE DEFECT; DISORIENTATION; HALLUCINATION; HUMAN; PARANOIA; PRIORITY JOURNAL; PSYCHOSIS; REVIEW; SIDE EFFECT;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; COGNITION DISORDERS; HUMAN; MENINGITIS, ASEPTIC; PSYCHOSES, SUBSTANCE-INDUCED;

EID: 0025915769     PISSN: 00039926     EISSN: 15383679     Source Type: Journal    
DOI: 10.1001/archinte.1991.00400070083009     Document Type: Article

References (51)

1. 1. Barrier CH, Hirschowitz BI. Controversies in the detection and management of nonsteroidal antiinflammatory drug-induced side effects of the upper gastrointestinal tract. Arthritis Rheum. 1989;32:925-932.
2. 2. Baum C, Kennedy DL, Forbes MD. Utilization of nonsteroidal antiflammatory drugs. Arthritis Rheum. 1985;28:686-692.
3. 3. lobst WF, Bridges CR, Regan-Smith MG. Antirheumatic agents: CNS toxicity and its avoidance. Geriatrics. 1989;44:95-102.
4. 4. Sachs RM, Bortnichak EA. An evaluation of spontaneous adverse drug reaction monitoring systems. Am J Med. 1986;81(suppl 5B):49-55.
5. 5. Paulus H. FDA Arthritis Advisory Committee Meeting: postmarketing surveillance of nonsteroidal antiinflammatory drugs. Arthritis Rheum. 1985;28:1168-1169.
6. 6. Coles LS, Fries JF, Kraines RG, Roth SH. From experiment to experience: side effects of nonsteroidal anti-inflammatory drugs. Am J Med. 1983;74:820-828.
7. 7. Kurowski M. The design of SPALA (Safety Profile of Antirheumatics in Long-term Administration). Eur J Clin Pharmacol. 1988;34:529-530.
8. 8. Widener HL, Littman BH. Ibuprofen-induced meningitis in systemic lupus erythematosis. JAMA. 1978;239:1062-1064.
9. 9. Giansiracusa DF, Blumberg S, Kantrowitz FG. Aseptic meningitis associated with ibuprofen. Arch Intern Med. 1980;140:1553.
10. 10. Wasner CK. Ibuprofen, meningitis, and systemic lupus erythematosus. J Rheum. 1978;5:162-164.
11. 11. Samuelson CO Jr, Williams HJ. Ibuprofen-associated aseptic meningitis in systemic lupus erythematosus. West J Med. 1979;131:57-59.
12. 12. Ruppert GB, Barth WF. Ibuprofen hypersensitivity in systemic lupus erythematosus. South Med J. 1981;74:241-243.
13. 13. Gilbert GJ, Eichenbaum HW. Ibuprofen-induced meningitis in an elderly patient with systemic lupus erythematosus. South Med J. 1989;82:514-515.
14. 14. Mandell BF, Raps EC. Severe systemic hypersensitivity reaction to ibuprofen occurring after prolonged therapy. Am J Med Sci. 1987;82:817-820.
15. 15. Jensen S, Glud TK, Bacher T, Ersgaard H. Ibuprofen-induced meningitis in a male with systemic lupus erythematosus. Acta Med Scand. 1987;221:509-511.
16. 16. Katona BG, Wigley FM, Walters JK, Caspi M. Aseptic meningitis from over-the-counter ibuprofen. Lancet. 1988;1:59.
17. 17. Peck MG, Joyner PU. Ibuprofen-associated aseptic meningitis. Clin Pharm. 1982;1:561-565.
18. 18. Bernstein RF. Ibuprofen-related meningitis in mixed connective tissue disease. Ann Intern Med. 1980;92:206-207.
19. 19. Hoffman M, Gray RG. Ibuprofen-induced meningitis in mixed connective tissue disease. Clin Rheumatol. 1982;1:128-130.
20. 20. Perera DR, Seiffert AK, Greeley HM. Ibuprofen and meningo-encephalitis. Ann Intern Med. 1984;100:619.
21. 21. Bouland DL, Specht NL, Hegstad DG. Ibuprofen and aseptic meningitis. Ann Intern Med. 1986;104:731.
22. 22. Lawson JM, Grady MJ. Ibuprofen-induced aseptic meningitis in a previously healthy patient. West J Med. 1985;143:386-387.
23. 23. Ewert BH. Ibuprofen-associated meningitis in a woman with only serologic evidence of a rheumatologic disorder. Am J Med Sci. 1989;297:326-327.
24. 24. Quinn JP, Weinstein RA, Caplan LR. Eosinophilic meningitis and ibuprofen therapy. Neurology. 1984;34:108-109.
25. 25. Ballas ZK, Donta ST. Sulindac-induced aseptic meningitis. Arch Intern Med. 1982;142:165-166.
26. 26. Von Reyn CF. Recurrent aseptic meningitis due to sulindac. Ann Intern Med. 1983;99:343-344.
27. 27. Greenberg GN. Recurrent sulindac-induced aseptic meningitis in a patient tolerant to other nonsteroidal anti-inflammatory drugs. South Med J. 1988;81:1463-1464.
28. 28. Neufeld MY, Korczyn AD. Encephalopathy associated with sulindac. Hum Toxicol. 1986;5:55.
29. 29. Sylvia LM, Forlenza SW, Brocavich JM. Aseptic meningitis associated with naproxen. Drug Intell Clin Pharm. 1988;22:399-401.
30. 30. Ruppert GB, Barth WF. Tolmentin-induced aseptic meningitis. JAMA. 1981;245:67-68.
31. 31. Finch WR, Strottman MP. Acute adverse reactions to ibuprofen in systemic lupus erythematosus. JAMA. 1979;241:2616-2618.
32. 32. Canoso J, Cohen A. Aseptic meningitis in systemic lupus erythematosus. Arthritis Rheum. 1975;18:369-374.
33. 33. Berliner S, Weinberger A, Shoenfeld Y, et al. Ibuprofen may induce meningitis in (NZB X NZW) F1 mice. Arthritis Rheum. 1985;28:104-107.
34. 34. Shoenfeld Y, Livni E, Shaklai M, Pinkas J. Sensitization to ibuprofen in systemic lupus erythematosus. JAMA. 1980;244:547-548.
35. 35. Garugusi V, Neefe L, Mann O. Acute meningoencephalitis associated with isoniazide administration. JAMA. 1976;235:1141-1142.
36. 36. Kremer I, Ritz R, Brunner F. Aseptic meningitis as an adverse effect of cotrimoxazole. N Engl J Med. 1983;308:1481.
37. 37. Sergent JS, Lockshin MD, Klempner MS, Lipsky BA. Central nervous system disease in systemic lupus erythematosus. Am J Med. 1975;58:644-654.
38. 38. O’Brien WM. Indomethacin: a survey of clinical trials. Clin Pharm Ther. 1968;9:94-106.
39. 39. Carney MWP. Paranoid psychosis with indomethacin. Br Med J. 1977;2:994-995.
40. 40. Schwartz JI, Moura RJ. Severe depersonalization and anxiety associated with indomethacin. South Med J. 1983;76:679-680.
41. 41. Thornton T. Delirium associated with sulindac. JAMA. 1980;243:1630-1631.
42. 42. Kruis R, Barger R. Paranoid psychosis with sulindac. JAMA. 1980;243:1420.
43. 43. Singh RPN, Sinha AKN. Organic psychosis with indomethacin. J Indian Med Assoc. 1978;8:210.
44. 44. Gotz V. Paranoid psychosis with indomethacin. BMJ. 1978;1:49.
45. 45. Paulus HE. Furst DE. Aspirin and other nonsteroidal anti-inflammatory drugs. In: McCarthy DJ, ed. Arthritis and Allied Conditions: A Textbook of Rheumatology. Philadelphia, Pa: Lea & Febiger; 1989:525.
46. 46. Griffith JD, Smith CH, Smith RC. Paranoid psychosis in a patient receiving ibuprofen, a prostaglandin synthesis inhibitor: case report. J Clin Psychiatry. 1982;43:499-500.
47. 47. Horrobin DF. The role of prostaglandins and prolactin in depression, mania, and schizophrenia. Postgrad Med J. 1977;53(suppl 4):160-165.
48. 48. Spittle BJ. Drug-induced psychiatric syndromes. N Z Med J. 1982;95:349-352.
49. 49. Simon LS, Mills JA. Nonsteroidal antiinflammatory drugs. N Engl J Med. 1980;302:1179-1185.
50. 50. Goodwin JS, Regan M. Cognitive dysfunction associated with naproxen and ibuprofen in the elderly. Arthritis Rheum. 1982;25:1013-1015.
51. 51. Wysenbeek AJ, Klein Z, Nakar S, Mane R. Assessment of cognitive function in elderly patients treated with naproxen: a prospective study. Clin Exp Rheumatol. 1988;6:399-400.