Site‐specific insertion of genes into integrons: role of the 59‐base element and determination of the recombination cross‐over point

Molecular Microbiology

Volumn 5, Issue 8, 1991, Pages 1941-1959

  Hall, R M ^a   Brookes, D E ^a   Stokes, H W ^b  

^a CSIRO MOLECULAR AND HEALTH TECHNOLOGIES   (Australia)

^b MACQUARIE UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DNA RECOMBINATION; DNA SEQUENCE; GENE INSERTION; INTEGRON; NONHUMAN; PLASMID; PRIORITY JOURNAL; TRANSPOSON;

BASE SEQUENCE; CONSENSUS SEQUENCE; DNA NUCLEOTIDYLTRANSFERASES; DNA TRANSPOSABLE ELEMENTS; ESCHERICHIA COLI; INTEGRASE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; MUTAGENESIS, SITE-DIRECTED; PLASMIDS; RECOMBINATION, GENETIC; REPETITIVE SEQUENCES, NUCLEIC ACID; SUPPORT, NON-U.S. GOV'T;

EID: 0025915621     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.1991.tb00817.x     Document Type: Article

References (49)

1. Physical and genetic map of the IncW plasmid R388
2. Nucleotide sequence of the PSE‐4 carbenicillinase gene and correlations with the Staphylococcus aureus PC1 β‐lactamase crystal structure
3. Nucleotide sequence of the AAD(2″) aminoglycoside adenylyltransferase determinant aadB. Evolutionary relationship of this region with those surrounding aadA in R538–1 and dhfrII in R388
4. Construction and characterisation of amplifiable multicopy DNA cloning vehicles derived from the p15A cryptic miniplasmid
5. Characterization of transferable plasmids from Shigella flexneri 2A that confer resistance to trimethoprim, streptomycin, and sullonamides
6. Sequence of the OXA2 β‐lactamase: comparison with other penicillin‐reactive enzymes
7. Trimethoprim resistance conferred by W plasmid in Enterobacteriacae
8. Genetic and molecular charactensation of Tn21, a multiple resistance transposon from R100‐1
9. Nucleotide sequence of the R26 chloramphenicol resistance determinant and identification of its gene product
10. Nucleotide sequence analysis of the trimethoprim resistant dihydrofolate reductase encoded by R plasmid R751
11. The nucleotide sequence of the trimethoprim‐resistant dihydrofolate reductase gene harbored by Tn7
12. Nucleotide sequence of the transposon Tn7 gene encoding an aminoglycoside‐modifying enzyme, 3″(9)‐O‐nucleotidyl‐transferase
13. The Tn21 subgroup of bacterial transposable elements
14. Nucleotide sequence of the sulfonamide resistance gene from plasmid R46
15. The region of the IncN plasmid R46 coding for resistance to β‐lactam antibiotics, streptomycin/spectinomycin and sulphonamides is closely related to antibiotic resistance segments found in IncW plasmids and in Tn21‐like transposons
16. Nucleotide sequence of a plasmid born streptothricin‐acetyl‐transferase gene (sat‐1)
17. Construction of a Tn5 derivative determining resistance to gentamicin and spectinomycin using a fragment cloned from R1033
18. Nucleotide sequence analysis of a gene encoding a streptomycin/spectinomycin adenyltransferase
19. Sequence of PSE‐2 β‐lactamase
20. Transposon Tn21 encodes a RecA‐independent site‐specific integration system
21. Genetic elements involved in Tn21 site‐specific integration, a novel mechanism for the dissemination of antibiotic resistance genes
22. Oxacillinhydrolysing β‐lactamases
23. Sequencing and expression of the 6′‐N‐acetyltransferase gene of transposon Tn 1331 from Klebsiella pneumoniae
24. Nucleotide sequence of an OXA‐2 β‐lactamase gene from the R‐plasmid R1767 derived plasmid pBP11 and comparison to closely related resistance determinants found in R46 and Tn2603
25. Homology of ORFs from Tn2603 and from R46 to site‐specific recombinases
26. Precise insertion of antibiotic resistance determinants into Tn21‐like transposons: nucleotide sequence of the OXA‐1 β‐lactamase gene
27. DNA sequencing with chain‐terminating inhibitors
28. The role of insertions, deletions, and substitutions in the evolution of R6 related plasmids encoding aminoglycoside transferase ANT‐(2″)
29. Evolutionary relationship between Tn21‐like elements and pBP201, a plasmid from Klebsiella pneumoniae mediating resistance to gentamicin and eight other drugs
30. Nucleotide sequence analysis of 2″‐aminoglycoside nucleotidyl‐transferase ANT(2″) from Tn4000: its relationship with AAD(3″) and impact on Tn21 evolution
31. Structure and function of hot spots providing signals for site‐directed specific recombination and gene expression in Tn21 transposons
32. Isolation, characterization, and DNA sequence analysis of an AAC(6′)‐II gene from Pseudomonas aeruginosa
33. Identification of the type I trimethoprim‐resistant dihydrofolate reductase specified by the Escherichia coli R‐plasmid R483: comparison with procaryotic and eucaryotic dihydrofolate reductases
34. A novel family of potentially mobile DNA elements encoding site‐specific gene‐integration functions: integrons
35. Sequence analysis of the inducible chloramphenicol resistance determinant in the Tn 1696 integron suggests regulation by translational attenuation
36. The dhfrl trimethoprim resistance gene of Tn7 can be found at specific sites in other genetic surroundings
37. Site‐specific recombination promotes linkage between trimethoprim‐ and sulfonamide resistance genes. Sequence characterization of dhfrV and sul I and a recombination active locus of Tn21
38. DNA sequence of a plasmid‐encoded dihydrofolate reductase
39. The aminoglycoside‐resistance operon of the plasmid pSa: nucleotide sequence of the streptomycin‐spectinomycin resistance gene
40. Cloning and sequencing of a gene encoding an aminoglycoside 6′‐N‐acetyltransferase from an R factor of Citrobacter diversus
41. Development of a DNA probe from the deoxyribonucleotide sequence of a 3‐N‐aminoglycoside acetyltransferase [AAC(3)‐I] resistance gene
42. Nucleotide sequence of the streptothricin‐acetyl‐transferase gene sat‐2
43. Relationships among the streptothricin resistance transposons Tn1825 and Tn1826 and the trimethoprim resistance transposon Tn7
44. Primary structure of an aminoglycoside 6′‐N‐acetyltransferase, AAC(6′)‐4, fused in vivo with the signal peptide of the Tn3‐encoded β‐lactamase
45. Insertions of resistance genes into Tn21‐liKe transposons
46. On the evolution of the Tn21‐like multiresistance transposons: sequence analysis of the gene (aacC1) for gentamicin acetyltransferase‐3‐I(AAC(3)‐I), another member of the Tn21‐based expression cassette
47. Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13 mp18 and pUC19 vectors
48. Characterization of a R plasmid‐associated, trimethoprim‐resistant dihydrofolate reductase and determination of the nucleotide sequence of the reductase gene