Liquid chromatographic separation of the enantiomers of metoprolol and its α-hydroxy metabolite on Chiralcel OD for determination in plasma and urine

Journal of Chromatography A

Volumn 553, Issue C, 1991, Pages 391-397

  Balmér, Karin ^a   Persson, Annika ^a   Lagerström, Per olof ^a   Persson, Bengt Arne ^a   Schill, Göran ^b  

^a Bioanalytical Chemistry   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETOPROLOL; METOPROLOL; UNCLASSIFIED DRUG;

CONFERENCE PAPER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PLASMA; PRIORITY JOURNAL; URINE;

ANIMAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; HUMAN; METOPROLOL; SPECTROMETRY, FLUORESCENCE; STEREOISOMERISM;

EID: 0025911950     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9673(01)88509-5     Document Type: Article

References (12)

1. Optimization of detection sensitivity for enantiomers of metoprolol on silica-bonded ?1-acid glycoprotein
2. Optical resolution of .BETA.-blockers by HPLC on cellulose triphenylcarbamate derivatives.
3. Determination of metaprolol and two major metabolites in plasma and urine by column liquid chromatography and fluorometric detection