Discontinuation of neuroleptic medication in older, outpatient schizophrenics a placebo-controlled, double-blind trial

Journal of Nervous and Mental Disease

Volumn 179, Issue 4, 1991, Pages 212-214

  Ruskin, Paul E ^a,b   Nyman, Gary ^a,b  

^a BALTIMORE VA MEDICAL CENTER   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HALOPERIDOL;

ADULT; AGED; ARTICLE; HUMAN; MAJOR CLINICAL STUDY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; SCHIZOPHRENIA;

AGE FACTORS; AMBULATORY CARE; ANTIPSYCHOTIC AGENTS; COMPARATIVE STUDY; DOUBLE-BLIND METHOD; FOLLOW-UP STUDIES; HALOPERIDOL; HUMAN; MIDDLE AGE; PATIENT DROPOUTS; PLACEBOS; RECURRENCE; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SUPPORT, U.S. GOV'T, NON-P.H.S.;

EID: 0025907156     PISSN: 00223018     EISSN: 1539736X     Source Type: Journal    
DOI: 10.1097/00005053-199104000-00006     Document Type: Article

References (25)

1. Bleuler M (1976) Long-term course of schizophrenic psychoses. Annu Rev Schizoph Syndrome 4;435-453.
2. Carpenter WT, Heinrichs DW (1983) Early intervention, time-lim-ited targeted pharmacotherapy in schizophrenia. Schizophr Bull 9:533-542.
3. Carpenter WT, Heinrichs DW (1984) Intermittent pharmacotherapy of schizophrenia. In JM Kane (Ed), Drug maintenance strategies in schizophrenia (pp 70-82). Washington, DC: American Psychiatric Press.
4. Carpenter WT, Stephens JH, Rey AC, et al (1982) Early intervention vs. continuous pharmacotherapy of schizophrenia. Psycho-pharmacol Bull 18:21-23.
5. Ciompi L (1980) The natural history of schizophrenia in the long term. Br J Psychiatry 136:413-420.
6. Ciompi L (1987) Review of follow-up studies on long-term evolution and aging in schizophrenia. In NE Miller, CD Cohen (Eds), Schizophrenia and aging (pp 37-51). New York: Guilford.
7. Davis J (1974) Dose equivalence of the antipsychotic drugs. J Psychiatr Res 11:65-69.
8. Davis J (1975) Overview: Maintenance therapy in psychiatry: I. Schizophrenia. Am J Psychiatry 132:1237-1245.
9. Harding CM, Brooks GW, Ashikaga T, et al (1987a) The Vermont Longitudinal Study: II. Long-term outcome for DSM-III schizophrenia. Am J Psychiatry 144:727-735.
10. Harding CM, Zubin J, Strauss JS (1987b) Chronicity in schizophrenia: Fact, partial fact, or artifact? Hosp Community Psychiatry 38:477-486.
11. Heinrichs DW, Hanlon TE, Carpenter WT (1984) The Quality of Life Scale: An instrument for rating the schizophrenic deficit syndrome. Schizophr Bull 10:388-398.
12. Herz MI, Szymanski HV, Simon JC (1982) Intermittent medication for stable schizophrenic outpatients: An alternative to maintenance medication. Am J Psychiatry 139:918-922.
13. Hogarty GE, Ulrich RF, Mussare F, et al (1976) Drug discontinuation among long-term successfully maintained schizophrenic outpatients. Dis Nerv Syst 37:494-500.
14. Huber G, Gross G, Schuttler R, Linz M (1980) Longitudinal studies of schizophrenic patients. Schizophr Bull 6:592-605.
15. Jenike MA (1983) Tardive dyskinesia: Special risk in the elderly. J Am Geriatr Soc 31:71-73.
16. Johnson GRS, Hunt GE, Rey JM (1982) Incidence and severity of tardive dyskinesia with age. Arch Gen Psychiatry 39:486.
17. Kane JM (1983) Low dose medication strategies in the maintenance treatment of schizophrenia. Schizophr Bull 9:528-532.
18. Kane JM, Rifkin A, Woerner M, et al (1985) High-dose versus low-dose strategies in the treatment of schizophrenia. Psychophar-macol Bull 21:533-537.
19. Kane JM, Rifkin A, Woerner M, et al (1983) Low dose neuroleptic treatment of outpatient schizophrenics. Arch Gen Psychiatry 40:893-896.
20. Kane JM, Smith JM (1982) Tardive dyskinesia: Prevalence and risk factors, 1959-1979. Arch Gen Psychiatry 39:473-481.
21. Lehmann HE, Wilson WH, Deutsch M (1983) Minimal maintenance medication: Effects of three dose schedules on relapse rates and symptoms in chronic schizophrenic outpatients. Comp Psychiatry 31:117-119.
22. Overall JE, Gorham DR (1962) The Brief Psychiatric Rating Scale. Psychol Rep 10:799-802.
23. Smith JM, Baldessarini RJ (1980) Changes in prevalence, severity, and recovery of tardive dyskinesia with age. Arch Gen Psychiatry 37:1368-1373.
24. Thompson TL II, Moran MG, Nies AS (1983) Psychotropic drug use in the elderly. N Engl J Med 308:194-199.
25. Tsuang M, Woolson R, Fleming J (1979) Long-term outcome of major psychoses: I. Schizophrenia and affective disorders compared with psychiatrically symptom-free surgical conditions. Arch Gen Psychiatry 36:1295-1301.