Insulin-like growth factor-I binds selectively to human peripheral blood monocytes and B-lymphocytes

Journal of Clinical Endocrinology and Metabolism

Volumn 72, Issue 5, 1991, Pages 1117-1122

  Stuart, Charles A ^a   Meehan, Richard T ^b,c   Neale, Laureen S ^c   Cintron, Nitza M ^c   Furlanetto, Richard W ^d  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c NASA JOHNSON SPACE CENTER   (United States)

^d UNIVERSITY OF ROCHESTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; SOMATOMEDIN C;

ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; MONOCYTE; NORMAL HUMAN; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; AUTORADIOGRAPHY; B-LYMPHOCYTES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LEUKOCYTES, MONONUCLEAR; RECEPTORS, CELL SURFACE; RECEPTORS, SOMATOMEDIN; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0025907012     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jcem-72-5-1117     Document Type: Article

References (17)

1. Unahue ER, Allen PM. The basis for the immunoregulatory role of macrophages and other accessory cells. Science. 1987;236:551-7.
2. Hunt P, Eardley DD. Suppressive effects of insulin and insulinlike growth factor-1 (IGFl) on immune responses. J Immunol. 1986;136:3994-9.
3. Thorsson AV, Hintz RL. Specific 125-I-somatomedin receptor of circulating human mononuclear cells. Biochem Biophys Res Commun. 1977;74:1566-73.
4. Rosenfeld RG, Thorsson AV, Hintz RL. Increased somatomedin receptor sites in newborn circulating mononuclear cells. J Clin Endocrinol Metab. 1979;48:456-61.
5. Rosenfeld RG, Kemp SF, Gaspich S, Hintz RL. In uivo modulation of somatomedin receptor sites: effects of growth hormone treatment of hypopituitary children. J Clin Endocrinol Metab. 1981;52:759-64.
6. Rechler MM, Nissley SP. Receptors for insulinlike growth factors. In: Posner BI, ed. Polypeptide hormone receptors. Dekker: New York; 1985:227-97.
7. Schwartz RH, Bianco AR, Handwerger BS, Kahn CR. Demonstration that monocytes rather than lymphocytes are the insulinbinding cells in preparations of human peripheral blood mononuclear leukocytes: implications for studies of insulin-resistant state in man. Proc Nat Acad Sci USA. 1975;72:474-8.
8. Kull FC, Jacobs S, Su Y, Svoboda ME, Van Wyk JJ, Cuatrecasas P. Monoclonal antibodies to receptors for insulin and somatome-din-C. J Biol Chem. 1983;258:6561-6.
9. Stuart CA, Armstrong RM, Provow SA, Plishker GA. Insulin resistance in patients with myotonic dystrophy. Neurology. 1983;33:679-85.
10. Freychet P, Roth J, Neville DM. Monoidoinsulin: demonstration of its biologic activity and binding to fat cells and liver membranes. Biochem Biophys Res Commun. 1971;43:400-8.
11. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-5.
12. Stuart CA. Characteristics of a novel insulin receptor from stingray liver. J Biol Chem. 1988;263:7881-6.
13. Meehan R, Duncan U, Neale L, et al. Operation Everest II: alteration in the immune system at high altitudes. J Clin Immunol. 1988;8:397-406.
14. Helderman JH, Strom TB. Specific insulin binding site on T and B lymphocytes as a marker of cell activation. Nature. 1978;274:62-3.
15. Helderman JH, Ayuso R, Rosenstock J, Raskin P. Monocyte-T lymphocyte interaction for regulation of insulin receptors on the activated T lymphocyte. J Clin Invest. 1987;79:566-71.
16. Kozak RW, Haskell JF, Greenstein LA, Rechler MM, Waldmann TA, Nissley SP. Type I and II insulin-like growth factor receptors on human phytohemagglutinin-activated T lymphocytes. Cell Immunol. 1987;109:318-31.
17. Geffner ME, Bersch N, Lippe BM, Rosenfeld RG, Hintz RL, Golde DW. Growth hormone mediates the growth of T-lymphoblast cell lines via locally generated insulin-like growth factor-I. J Clin Endocrinol Metab. 1990;71:464-9