The E2F transcription factor is a cellular target for the RB protein

Cell

Volumn 65, Issue 6, 1991, Pages 1053-1061

  Chellappan, Srikumar P ^a,b   Hiebert, Scott ^a,b   Mudryj, Maria ^a,b   Horowitz, Jonathan M ^b   Nevins, Joseph R ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRIDAE;

GENE PRODUCT; TRANSCRIPTION FACTOR;

ARTICLE; CELL GROWTH; DNA PROTEIN COMPLEX; GENETIC TRANSFORMATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RETINOBLASTOMA;

ADENOVIRUS EARLY PROTEINS; CYCLINS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMAN; IN VITRO; MACROMOLECULAR SYSTEMS; ONCOGENE PROTEINS, VIRAL; PHOSPHOPROTEINS; RETINOBLASTOMA PROTEIN; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0025905183     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(91)90557-F     Document Type: Article

References (52)

1. Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation
2. Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein
3. Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo
4. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle
5. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation
6. RB and the cell cycle: entrance or exit
7. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
8. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element
9. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
10. Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein
11. Binding of the Rb1 protein to E1A products is required for adenovirus transformation
12. Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein
13. Structural evidence for the authenticity of the human retinoblastoma gene
14. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC
15. An adenovirus early region 4 gene product is required for induction of the infection-specific form of cellular E2F activity
16. Association of adenovirus early region 1A proteins with cellular polypeptides
17. E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor
18. Point mutational inactivation of the retinoblastoma antioncogene
19. Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells
20. Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection
21. A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product
22. Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product
23. Regulation of transforming growth factor β1 gene expression by the product of the retinoblastoma-susceptibility gene
24. Identification of a cellular transcription factor involved in E1A trans-activation
25. Inactivation of the retinoblastoma susceptibility gene in human breast cancers
26. The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity
27. The adenovirus EIIA enhancer. Analysis of regulatory sequences and changes in binding activity of ATF and EIIF following adenovirus infection
28. SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family
29. Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product
30. Analysis of the proliferating cell nuclear antigen promoter and its response to adenovirus early region 1
31. Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A
32. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product
33. An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F
34. TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains
35. cdc2
36. Activation of the E2F transcription factor in adenovirus infected cells involves an E1A-dependent stimulation of DNA binding and induction of cooperative binding mediated by an E4 gene product
37. Domains of the adenovirus E1A protein that are required for oncogenic activity are also required for dissociation of E2F transcription factor complexes
38. Negative regulation of human c-fos expression by the retinoblastoma gene product
39. c-arc at the sites phosphorylated during fibroblast mitosis
40. Induction of human heat shock gene transcription by the adenovirus E1A gene, including the 12S E1A product
41. Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity
42. Structural rearrangement of the retinoblastoma gene in human breast carcinoma
43. In vitro phosphorylation of the tumor suppressor gene Rb protein by mitosis-specific histone H1 kinase
44. The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours
45. Some retinoblastomas, osteosarcomas, and soft tissue sarcomas may share a common etiology
46. Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product
47. Cellular targets for transformation by the adenovirus E1A proteins
48. The retinoblastoma susceptibility gene product: a characteristic pattern in normal cells and abnormal expression in malignant cells
49. The adenovirus-inducible factor E2F stimulates transcription after specific DNA binding
50. Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides
51. Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung
52. Different functional domains of the adenovirus E1A gene are involved in regulation of host cell cycle products