Sensitivity and tolerance to nicotine in smokers and nonsmokers

Psychopharmacology

Volumn 105, Issue 1, 1991, Pages 63-68

  Srivastava, E D ^a   Russell, M A H ^b   Feyerabend, C ^b   Masterson, J G ^c   Rhodes, J ^a  

^a UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c ELAN PHARMACEUTICALS   (United States)

Author keywords

Cigarette smoking; Nicotine pharmacokinetics; Nicotine tolerance; Transdermal nicotine

Indexed keywords

NICOTINE;

ADULT; AGED; ARTICLE; CIGARETTE SMOKING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG SENSITIVITY; DRUG TOLERANCE; FEMALE; HEADACHE; HUMAN; MALE; NAUSEA; NORMAL HUMAN; PRIORITY JOURNAL; TRANSDERMAL DRUG ADMINISTRATION; VOMITING;

ADMINISTRATION, CUTANEOUS; ADULT; BLOOD PRESSURE; DRUG TOLERANCE; FEMALE; HEART RATE; HUMAN; MALE; MIDDLE AGE; NICOTINE; SMOKING; SUPPORT, NON-U.S. GOV'T;

EID: 0025900867     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/BF02316865     Document Type: Article

References (29)

1. Controlled trial of transdermal nicotine patch in tobacco withdrawal
2. Transdermal delivery of nicotine in normal human volunteers: a single dose and multiple dose study
3. Effect of smoking on nicotine metabolism in vivo in man
4. Enzyme induction in man caused by smoking
5. Pharmacologic aspects of cigarette smoking and nicotine addiction
6. Interindividual variability in metabolism and cardiovascular effects of nicotine in man
7. Evidence that tobacco smoking increases the density of nicotine binding sites in human brain
8. Nicotine and smoking: a perspective from animal studies
9. Pharmacokinetics and bioavailability of nicotine in healthy volunteers following single and repeated administration of different doses of transdermal nicotine systems
10. A rapid gas-liquid chromatographic method for the determination of cotinine and nicotine in biological fluids
11. Neurochemical mechanisms underlying the neuroendocrine actions of nicotine: focus on the plasticity of central cholinergic nicotinic receptors
12. Non-smoking: a feature of ulcerative colitis
13. Regulation of nicotinic cholinergic recognition sites and prolactin release by nicotine
14. Smoking-induced changes in nicotine disposition: application of a new HPLC assay for nicotine and its metabolites
15. On the local paralysis of peripheral ganglia, and on the connection of different classes of nerve fibres with them
16. Nicotine-induced tolerance and receptor changes in four mouse strains
17. The occurrence of tolerance to a central depressant effect of nicotine
18. Late presentation of ulcerative colitis in ex-smokers
19. Clinical and pharmacokinetic properties of a transdermal nicotine patch
20. EEG effects in humans of nicotine, tobacco smoking, withdrawal from smoking and possible surrogates
21. Pharmacodynamic model of tolerance: application to nicotine
22. Does smoking improve colitis?
23. Nicotine replacement: the role of blood nicotine levels, their rate of change, and nicotine tolerance
24. Non-smokers show acute tolerance to subcutaneous nicotine
25. Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo
26. Rapid desensitisation of the acute stimulatory effects of nicotine on plasma adrenocorticotropin and prolactin
27. Acute and chronic tolerance to nicotine measured by activity in rats
28. Effects of nicotine on finger tapping rate in non-smokers
29. Cardiovascular and subjective effects of smoking before and after 24 h abstinence from cigarettes