Synthesis and Antitumor Activity of 20(S)-Camptothecin Derivatives: Carbamate-Linked, Water-Soluble Derivatives of 7-Ethyl-10-hydroxycamptothecin

Chemical and Pharmaceutical Bulletin

Volumn 39, Issue 6, 1991, Pages 1446-1454

  Sawada, Seigo ^a   Okajima, Satoru ^a   Aiyama, Ritsuo ^a   Nokata, Ken ichiro ^a   Furuta, Tomio ^a   Yokokura, Teruo ^a   Sugino, Eiichi ^b   Yamaguchi, Kentaro ^c   Miyasaka, Tadashi ^c  

^a YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

^b FUKUYAMA UNIVERSITY   (Japan)

^c SHOWA UNIVERSITY   (Japan)

Author keywords

20(S) camptothecin; 7 ethyl 10 hydroxycamptothecin; antitumor activity; carbamate; CPT 11; X ray crystallography

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; IRINOTECAN;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CRYSTALLOGRAPHY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LEUKEMIA; LEUKEMIA L 1210; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; STRUCTURE ACTIVITY RELATION; TUMOR CELL;

ANIMAL; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CARBAMATES; FEMALE; LEUKEMIA L1210; MICE; MICE, INBRED BALB C; MICE, INBRED ICR; SOLUBILITY; WATER;

EID: 0025899645     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.39.1446     Document Type: Article

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