Clonidine-displacing substance (CDS) and its putative imidazoline receptor. New leads for further divergence of α2-adrenergic receptor activity

Biochemical Pharmacology

Volumn 41, Issue 11, 1991, Pages 1541-1549

  Atlas, Daphne ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 CHLORO 5 TRIFLUOROMETHYLPHENYLIMINO)IMIDAZOLIDINE; ADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BRIMONIDINE; CIRAZOLINE; CLONIDINE; CLONIDINE DERIVATIVE; CLONIDINE DISPLACING SUBSTANCE; CYCLIC AMP; GUANABENZ; NAPHAZOLINE; NORADRENALIN; OXYMETAZOLINE;

BLOOD PRESSURE; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMAL; ANTIHYPERTENSIVE AGENTS; BINDING SITES; CLONIDINE; DRUG DESIGN; HUMAN; MODELS, BIOLOGICAL; RECEPTORS, ADRENERGIC, ALPHA; RECEPTORS, DRUG;

EID: 0025898449     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(91)90152-U     Document Type: Article

References (57)

1. Modulation of neurotransmitter release by presynaptic autoreceptors
2. 2-Adrenoceptors: Classiflcation, localization, mechanisms, and targets for drugs
3. B adrenergic receptor subtypes: Antagonist binding in tissues and cell lines containing only one subtype
4. 2-adrenergic effects of phenylethylamines and imidazolines
5. Central cardiovascular effects of alpha adrenergic drugs: Differences between catacholamines and imidazolines
6. 3H]idazoxan in rat brain
7. 2-adrenergic component of epinephrine
8. 2-adrenergic receptors. I. Inhibition of adenylate cyclase mediated by α receptors
9. Alpha-2 adrenoceptors beyond cAMP generation: islets of Langerhans and intestinal epithelium
10. 2-adrenergic agonists
11. 2+ and cyclie adenosine 3':5'-monophosphate in insulin release induced in vitro by the divalent cation ionophore A23187
12. Regulation of insulin release by calcium
13. 2-adrenergic inhibition of insulin release. Studies with epinephrine and insulin
14. Noradrenaline induced inhibition of voltage sensitive calcium currents in NG 108-15 hybrid cells
15. GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels
16. Interrelationships between clonidine and histaminergic mechanisms
17. Studies on the relationship between chemical constitution and physiological action V Molecular dissymmetry and physiological activity
18. Genetic approaches to the determination of structure-function relationships of G-protein-coupled receptors
19. Adrenoceptor-mediated effects of optically active catecholimidazolines in pithed rat
20. Isolation and partial purification of a clonidine-displacing endogenous brain substance
21. Isolation of an endogenous clonidine-displacing substance from rat brain
22. 2-adrenoceptors of human platelets
23. The brain's own clonidine: Purification and characterization of endogenous clonidine displacing substance from brain
24. Pharmacological characterization of the presynaptic α-adrenoceptor in the rat vas deferens
25. An endogenous brain substance, CDS (clonidine-displacing-substance), inhibits the twitch response of rat vas deferens
26. Clonidine-displacing-substance is biologically active on smooth muscle
27. An endogenous, non-catecholamine clonidine antagonist increases mean arterial blood pressure
28. Central cardiovascular effects of a noncatecholamine endogenous ligand for clonidine receptors
29. 2-adrenoceptor blockade in man
30. An endogenous clonidine-displacing substance from bovine brain: Receptor binding and hypotensive actions in the ventrolateral medulla
31. A specific antiserum recognizes clonidine displacing substance: Implications for the structure of the brain's own clonidine
32. Raised levels of an endogenous nonadrenergic substance in the serum of pregnancy-induced hypertension patients
33. 2-adrenoceptors in the ventrolateral medulla
34. An endogenous substance with clonidine-like properties: Selective binding to imidazole sites in the ventrolateral medulla
35. 2-adrenergic receptors
36. Evidence for imidazoline binding sites in basolateral membranes from rabbit kidney
37. 3H]idazoxan bind to different sites on rabbit forebrain and kidney membranes
38. Are there multiple imidazoline binding sites?
39. Guanabenz, guanochlor, guanoxan and idazoxan bind with high affinity to non-adrenergic sites in pig kidney membranes
40. 3H]idazoxan binding site in rabbit and human liver
41. 2-adrenergic receptors
42. 2-adrenergic drugs also bind with high affinity to a non-adrenergic site
43. 2-adrenoceptors in rabbit adipocyte membranes
44. 3H]yohimbine binding
45. 2-adrenergic receptor subtype
46. 50) of an enzymatic reaction
47. Imidazoline guanidinium receptive site in renal proximal tubule: Asymetric distribution, regulation by cations, and interaction with an endogenous clonidine displacing substance
48. 2-dopamine isoforms
49. Multiple Dz-dopamine receptors produced by alternative RNA splicing
50. 2-adrenergic receptors
51. 2-adrenoceptors: Pharmacological and molecular biological evidence converge
52. 2-adrenergic receptor
53. 2-Adreno-ceptor-mediated hyperpolarization of locus coeruleus neurons: Intracellular studies in vivo
54. 2-adrenoceptors which increase potassium conductance in rat locus coeruleus neurones
55. 2-autoreceptors
56. 2-adrenoceptor activation in guinea-pig submucous plexus neurones
57. 2-agonists in locus coeruleus neurons