Intracellular distribution and activity of antibiotics

European Journal of Clinical Microbiology & Infectious Diseases

Volumn 10, Issue 2, 1991, Pages 100-106

  Tulkens, P M ^a  

^a International Institute of Cellular and Molecular Pathology   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; CHLORAMPHENICOL; CIPROFLOXACIN; CLINDAMYCIN; LINCOMYCIN; LINCOSAMIDE; MACROLIDE; PEFLOXACIN; PENICILLIN G; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; ROXITHROMYCIN; TETRACYCLINE; TRIMETHOPRIM;

ANTIMICROBIAL ACTIVITY; BACTERIAL INFECTION; CYTOSOL; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG PENETRATION; HUMAN; INTRACELLULAR KILLING; LYSOSOME; PHAGOCYTE; PRIORITY JOURNAL; REVIEW;

ANTI-INFECTIVE AGENTS, QUINOLONE; ANTIBIOTICS; ANTIBIOTICS, AMINOGLYCOSIDE; ANTIBIOTICS, LACTAM; ANTIBIOTICS, MACROLIDE; BACTERIA; HUMAN; MACROPHAGES; STAPHYLOCOCCUS AUREUS; SUPPORT, NON-U.S. GOV'T;

EID: 0025896610     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/BF01964420     Document Type: Review

References (36)

1. Comparative biology of intracellular parasitism
2. Intracellular infection and drug targeting
3. Antimicrobial drugs, microorganisms and phagocytes
4. Uptake of3H-dihydrostreptomycin by macrophages in culture
5. The uptake and intracellular accumulation of aminoglycosides antibiotics in lysosomes of cultured fibroblasts
6. Nephrotoxicity of aminoglycosides
7. Gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts
8. Endocytosis
9. Aminoglycoside-induced lysosomal dysfunction in the kidney
10. Penetration of antimicrobials into tissue culture cells and leucocytes
11. Antibiotic uptake by alveolar macrophages
12. Antibiotic entry into human polymorphonuclear leukocytes
13. Antibiotic accumulation in human polymorphonuclear leucocytes and lymphocytes
14. Influence of conversion of penicillin G into a basic derivative on its accumulation and subcellular localization in cultured macrophages
15. Non-ionic diffusion and the excretion of weak acids and bases
16. Intracellular pH
17. Lysosomotropic agents
18. Clindamycin uptake by human neutrophils
19. Interactions of antibiotics and phagocytes
20. Antibiotic uptake by alveolar macrophages of smokers
21. Uptake, accumulation and egress of erythromycin by tissue culture cells of human origin
22. Cellular uptake and subcellular distribution of roxithromycin and crythromycin in phagocytic cells
23. In vitro and in vivo uptake of azithromycin (CP-62, 993) in phagocytic cells: possible mechanism of delivery and release at sites of infection
24. Uptake of ciprofloxacin by macrophages
25. Effect of ciprofloxacin on intracellular organisms: in vitro and in vivo studies
26. Intracellular penetration and distribution of antibiotics: the basis for an improved chemotherapy
27. Multiplication of tubercle bacilli within phagocytes cultivated in vitro, and effect of streptomycin and isonicotinic acid hydrazide
28. The bactericidal action of isoniazid, streptomycin and terramycin on extracellular and intracellular tubercle bacilli
29. The action of drugs on intracellular tubercle bacilli
30. In vitro studies on the interaction between mouse peritoneal macrophages and strains of Salmonella and Escherichia coli
31. Suppressive activity of streptomycin on the growth of Mycobacterium lepraemurium in macrophage cultures
32. Intracellular multiplication of legionnaires' disease bacteria (Legionella pneumophila) in human monocytes is reversibly inhibited by erythromycin and rifampin
33. Studies on ciprofloxacin therapy of experimental Legionnaires' disease
34. Inhibition of Legionella pneumophila multiplication within human macrophages by antimicrobial agents
35. Evaluation of antibacterial agents in a high-volume bovine polymorphonuclear neutrophil Staphylococcus aureus intracellular killing assay