Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Cell

Volumn 66, Issue 4, 1991, Pages 807-815

  Liu, Jun ^a   Farmer Jr , Jesse D ^a   Lane, Willam S ^a   Friedman, Jeff ^b   Weissman, Irving ^b   Schreiber, Stuart L ^a  

^a HARVARD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CYCLOPHILIN; CYCLOSPORIN A; IMMUNOGLOBULIN RECEPTOR; IMMUNOPHILIN; RAPAMYCIN; T LYMPHOCYTE RECEPTOR; TACROLIMUS;

ANIMAL TISSUE; ARTICLE; CATTLE; COMPLEX FORMATION; DRUG BINDING; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMINO ACID ISOMERASES; AMINO ACID SEQUENCE; ANIMAL; ANTIBIOTICS, MACROLIDE; BASE SEQUENCE; CALCINEURIN; CALMODULIN; CALMODULIN-BINDING PROTEINS; CARRIER PROTEINS; CATIONS, DIVALENT; CLONING, MOLECULAR; CYCLOSPORINS; HUMAN; IMMUNOSUPPRESSIVE AGENTS; IN VITRO; MACROMOLECULAR SYSTEMS; MICE; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; OLIGONUCLEOTIDES; OLIGOPEPTIDES; PEPTIDYLPROLYL ISOMERASE; PHOSPHOPROTEIN PHOSPHATASE; POLYENES; PROTEIN BINDING; SIROLIMUS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TACROLIMUS; TACROLIMUS BINDING PROTEINS;

EID: 0025893168     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(91)90124-H     Document Type: Article

References (43)

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3. Probing immunosuppressant action with a nonnatural immunophilin ligand
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5. “Western blotting”: electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A
6. The immunosuppressive macrolides FK506 and rapamycin act as reciprocal antagonists in murine T cells
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8. Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation
9. Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins
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13. A receptor for the immunosuppressant FK506 is a cis-trans peptidylprolyl isomerase
14. FK506-binding protein proline rotamase is a target for the immunosuppressive agent FK506 in Saccharomyces cerevisiae
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16. Functional domain structure of calcineurin A: mapping by limited proteolysis
17. Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription
18. Molecular cloning of a membrane-associated human FK506 and rapamycin binding protein, FKBP-13
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21. Purification of cyclic 3′,5′-nucleotide phosphodiesterase inhibitory protein by affinity chromatography on activator protein coupled to Sepharose
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30. Solution structure of the major binding protein for the immunosuppressant FK506
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32. Chemistry and biology of the immunophilins and their immunosuppressive ligands
33. A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin
34. Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?
35. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
36. The cyclophilin homolog ninaA is a tissue-specific integral membrane protein required for the proper synthesis of a subset of Drosophila rhodopsins
37. Molecular cloning and overexpression of the human FK506-binding Protein, FKBP
38. 2+- and calmodulin-dependent protein phosphatase
39. Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin
40. The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes
41. Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisiae
42. Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex