Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo

Journal of Clinical Investigation

Volumn 88, Issue 5, 1991, Pages 1613-1621

  Blume, S W ^a   Snyder, R C ^a   Ray, R ^a   Thomas, S ^a   Koller, C A ^a   Miller, D M ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

DNA binding drug; Gene amplification; Methotrexate resistance

Indexed keywords

DIHYDROFOLATE REDUCTASE; MITHRAMYCIN;

ARTICLE; BREAST CANCER; CANCER CELL; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING;

EID: 0025889742     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI115474     Document Type: Article

References (0)