Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth hormone (GH) secretion, insulin-like growth factor I, and gh-binding protein in postmenopausal women

Journal of Clinical Endocrinology and Metabolism

Volumn 72, Issue 2, 1991, Pages 374-381

  Weissberger, Andrew J ^a,b   Ho, Ken K Y ^a   Lazarus, Leslie ^a  

^a ST VINCENT S HOSPITAL   (Australia)

^b NATIONAL HEALTH AND MEDICAL RESEARCH COUNCIL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ETHINYLESTRADIOL; GROWTH HORMONE; GROWTH HORMONE BINDING PROTEIN; NORETHISTERONE; SOMATOMEDIN C;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ADMINISTRATION; FEMALE; HUMAN; MENOPAUSE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PULSATILE HORMONE RELEASE; TRANSDERMAL DRUG ADMINISTRATION;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, ORAL; AGED; CARRIER PROTEINS; COMPARATIVE STUDY; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; ETHINYL ESTRADIOL; FEMALE; GROWTH HORMONE; HUMAN; INSULIN-LIKE GROWTH FACTOR I; MENOPAUSE; MIDDLE AGE; SUPPORT, NON-U.S. GOV'T;

EID: 0025882208     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jcem-72-2-374     Document Type: Article

References (46)

1. Unger RH, Eisentraut AM, Madison LL, Siperstein MD. Fasting levels of growth hormone in men and women. Nature. 1965;205:804-05.
2. Frantz AG, Rabkin MT. Effects of estrogen and sex difference on secretion of human growth hormone. J Clin Endocrinol Metab. 1965;25:1470-80.
3. Merimee TJ, Rabinowitz D, Fineberg SE. Arginine-initiated release of human growth hormone: factors modifying the response in normal man. N Engl J Med. 1969;280:1434-38.
4. Thompson RG, Rodriguez A, Xowarski A, Blizzard RM. Growth hormone: metabolic clearance iates, integrated concentrations and production rates in normal adults and the effect of prednisone. J Clin Invest. 1972;51:3193-99.
5. Ho KY, Evans WS, Blizzard RM et al. Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. J Clin Endocrinol Metab. 1987;64:51-58.
6. Bennett AE, Wahner HW, Riggs BL, Hintz RL. Insulin-like growth factors I and II: aging and bone density in women. J Clin Endocrinol Metab. 1984;59:701-04.
7. Franchimont P, Urbain-Choffray D, Lambelin P, Fontaine M-A, Frangin G, Reginster J-Y. Effect of repetitive administration of growth hormone-releasing hormone on growth hormone secretion, insulin-like growth factor I, and bone metabolism in postmenopausal women. Acta Endocrinol (Copenh). 1989;120:121-28.
8. Schwander JC, Hauri C, Froesch ER. Synthesis and secretion of insulin-like growth factor and its binding protein by the perfused rat liver: dependence on growth hormone status. Endocrinology. 1983;113:297-305.
9. D’Ercole AJ, Stiles AD, Unde rwood LE. Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action. Proc Natl Acad Sci USA. 1984;81:935-39.
10. Chetkowski RJ, Meldrum DR, Steingold KA et al. Biological effects of transdermal estradiol. N Engl J Med. 1986;314:1615-20.
11. de Lignieres B, Basdevant A, Thomas G et al. Biological effects of estradiol-17B in postmenopausal women: oral versus percutaneous administration. J Clin Endocrinol Metab. 1986;62:536-41.
12. Selby PL, McGarrigle HHG, Feacock M. Comparison of the effects of oral and transdermal oestradiol administration on oestrogen metabolism, protein synthesis, gonadotropin release, bone turnover and climacteric symptoms in postmenopausal women. Clin Endocrinol (Oxf). 1989;30:241-249.
13. Herington AC, Ymer S, Steve ison J. Identification and characterization of specific binding proteins for growth hormone in normal human sera. J Clin Invest. 1986;77:1817-23.
14. Baumann G, Stolar MW, Amburn K, Barsano CP, deVries BC. A specific growth hormone-binding protein in human plasma: initial characterization. J Clin Endo:rinol Metab. 1986;62:134-41.
15. Baumann G, Amburn K, Shi w MA. The circulating growth hormone (GH) -binding protein complex: a major constituent of plasma GH in man. Endocrinology. 1988;122:976-84.
16. Veldhuis JD, Johnson ML. Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection. Am J Physiol. 1986;250:E486-93.
17. Wiedemann E, Schwartz E, Frantz AG. Acute and chronic estrogen effects upon serum somatomedin activity, growth hormone, and prolactin in man. J Clin Endocrinol Metab. 1976;42:942-52.
18. Wiedemann E, Schwartz E. Suppression of growth hormone-dependent human serum sulfation factor by estrogen. J Clin Endocrinol Metab. 1972;34:51-58.
19. Clemmons DR, Underwood LE, Ridgway EG, Kliman B, Kjellberg RN, van Wyk JJ. Estradiol t reatment of acromegaly: reduction of immunoreactive somatomedin-C and improvement in metabolic status. Am J Med. 1980;69:571-75.
20. Cuttler L, van Vliet G, Conte FA, Kaplan SL, Grumbach MM. Somatomedin-C levels in children and adolescents with gonadal dysgenesis: differences from age-matched normal females and effect of chronic estrogen replacement therapy. J Clin Endocrinol Metab. 1985;60:1087-92.
21. Ross JL, Cassorla FG, Skerca MC, Valk IM, Loriaux DL, Cutler GB. A preliminary study of the effect of estrogen dose on growth in Turner’s syndrome. N Engl J Med. 1983;309:1104-06.
22. Duursma SA, Bijlsma JWJ, Van Paassen HC, van Buul-Offers SC, Skottner-Lundin A. Changes in serum somatomedin and growth hormone concentrations after 3 weeks oestrogen substitution in post-menopausal women; a pilot study. Acta Endocrinol (Copenh). 1984;106:527-31.
23. Dawson-Hughes B, Stern D, Goldman J, Reichlin S. Regulation of growth hormone and somatonedin-C secretion in postmenopausal women: effect of physiologic al estrogen replacement. J Clin Endocrinol Metab. 1986;63:424-32.
24. Frohlander N, von Schoultz B. Growth hormone and somatomedin C during postmenopausal replacement therapy with oestrogen alone and in combination with an antioestrogen. Maturitas. 1988;9:297-302.
25. Baxter RC. The somatomedins: insulin-like growth factors. Adv Clin Chem. 1986;25:49-115.
26. Holly JMP, Wass JAH. Insulin-like growth factors: autocrine, paracrine or endocrine? New perspectives of the somatomedin hypothesis in the light of recent developments. J Endocrinol. 1989;122:611-18.
27. Murphy LJ, Friesen HG. Differential effects of estrogen and growth hormone on uterine and hepatic insulin-like growth factor I gene expression in the ovariectomized hypophysectomized rat. Endocrinology. 1988;122:325-32.
28. Roupas P, Herington AC. Cellular mechanisms in the processing of growth hormone and its receptor. Mol Cell Endocrinol. 1989;61:1-12.
29. Leung DW, Spencer SA, Cachianes G et al. Growth hormone receptor and serum binding protein: purification, cloning and expression. Nature. 1987;330:537-43.
30. Breier BH, Gluckman PD, Bass JJ. The somatotrophic axis in young steers: influence of nutritional status and oestradiol-17β on hepatic high- and low-affinity somatotrophic binding sites. J Endocrinol. 1988;116:169-77.
31. Berelowitz M, Szabo M, Frohman LA, Firestone S, Chu L, Hintz RL. Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary. Science. 1981;212:1279-81.
32. Gray TK, Mohan S, Linkhart TA, Baylink DJ. Estradiol stimulates in vitro the secretion of insulin-like growth factors by the clonal osteoblastic cell line, UMR106. Biochem Biophys Res Commun. 1989;158:407-12.
33. Hsu CJ, Hammond JM. Gonadotropins and estradiol stimulate immunoreactive insulin-like growth factor-1 production by porcine granulosa cells in vitro. Endocrinology. 1987;120:198-207.
34. Young R, Mesiano S, Hintz RL, Ralph M, Browne CA, Thorburn GD. Stimulation of growth in hypophysectomized lambs by estradiol and growth hormone. Proceedings of the Endocrine Society of Australia, Melbourne, 1989;32 (Abstract).
35. Parker MW, Johanson AJ, Rogol AD, Kaiser DL, Blizzard RM. Effect of testosterone on somatomedin-C concentrations in prepubertal boys. J Clin Endocrinol Metab. 1984;58:87-90.
36. Cara JF, Burstein S, Cuttler L, Moll GW Jr, Rosenfield RL. Growth hormone deficiency impedes the rise in plasma insulin-like growth factor I levels associated with precocious puberty. J Pediatr. 1989;115:64-68.
37. Ross JL, Pescovitz OH, Barnes K, Loriaux DL, Cutler GB. Growth hormone secretory dynamics in children with precocious puberty. J Pediatr. 1987;110:369-72.
38. Harris DA, van Vliet G, Egli CA et al. Somatomedin-C in normal puberty and in true precocious puberty before and after treatment with a potent luteinizing hormone-releasing hormone agonist. J Clin Endocrinol Metab. 1985;61:152-59.
39. Weissberger AJ, Hg KY, Lazarus L. Resolution of apparent growth hormone-dependent growth failure during puberty: a case report. Horm Res. 1989;32:148-150.
40. Davidson MB. Effect of growth hormone on carbohydrate and lipid metabolism. Endocr Rev. 1987;8:115-31.
41. Ho KY, Weissberger AJ. The antinatriuretic action of biosynthetic human growth hormone in man involves activation of the renin-angiotensin system. Metabolism. 1990;39:133-37.
42. Hammond CB, Maxson WS. Current status of estrogen therapy for the menopause. Fertil Steril. 1982;37:5-25.
43. Guler H-P, Zapf J, Scheiwiller E, Froesch ER. Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats. Proc Natl Acad Sci USA. 1988;85:4889-93.
44. Daughaday WH, Rotwein P. Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocr Rev. 1989;10:68-91.
45. Rudman D. Growth hormone, body composition, and aging. J Am Geriatr Soc. 1985;33:800-07.
46. Rudman D, Feller AG, Nagraj HS et al. Effects of human growth hormone in men over 60 years old. N Engl J Med. 1990;323:1-6.