Pharmacokinetic Analysis of Two-Step Approaches Using Bifunctional and Enzyme-conjugated Antibodies

Cancer Research

Volumn 51, Issue 12, 1991, Pages 3119-3130

  Jain, Rakesh K ^a,a   Baxter, Laurence T ^a  

^a CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; MONOCLONAL ANTIBODY;

ARTICLE; CANCER IMMUNOTHERAPY; MATHEMATICAL MODEL; PHARMACOKINETICS; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; DRUG CARRIERS; ENZYMES; HAPTENS; HUMAN; KINETICS; MATHEMATICS; MODELS, BIOLOGICAL; NEOPLASMS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS;

EID: 0025880550     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Jain, R. K. Delivery of novel therapeutic agents in tumors: physiological barriers and strategies. J. Nati. Cancer Inst., 81: 570-576, 1989.
2. Raso. V., and Griffin. T. Hybrid antibodies with dual specificity for the delivery of ricin to immunoglobulin-bearing target cells. Cancer Res., 41: 2073-2078.1981.
3. Stickney. D. R., Slater. J. B., Kirk, G. A., Ahlem. C, Chang, C. and Frincke, J. M. Bifunctional antibody: ZCE/CHA ‘indium BLEDTA-IV clinical imaging in colorectal carcinoma. Antibody. Immunoconjugates, Radiopharmaceuticals, 2: 1-13, 1989.
4. Bagshawe. K. D., Springer, C. J., Searle, F., Antoniw. P., Sharma, S. K., Melton, R. G., and Sherwood, R. F. A cytotoxic agent can be generated selectively at cancer sites. Br. J. Cancer, 58: 700-703, 1988.
5. Senter. P. D., Saulnier, M. G., Schreiber, G. J., Hirschberg, D. L., Brown, J. P., Hellstrom. I., and Hellstrom, K. E. Anti-tumor effects of antibodyalkaline phosphatase conjugates in combination with etoposide phosphate. Proc. Nati. Acad. Sci. USA, 85: 4842-4846. 1988.
6. Senter, P. D., Schreiber, G. J., Hirschberg, D. L., Ashe. S. A., Hellstrpm. K. E., and Hellstrom. I. Enhancement of the in vitro and in viro antitumor activities of phosphorylated mitomycin C and etoposide derivatives by mono clonal antibody-alkaline phosphatase conjugates. Cancer Res., 49: 5789-5792, 1989.
7. Eger. R. R., Covell. D. G., Carrasquillo. J. A., Abrams, P. G., Foon, K. A., Reynolds, J. C., Schroff. R. W., Morgan, A.C., Larson. S. M., and Weinstein, J. N. Kinetic model for the biodistribution of an ‘In-labeled monoclonal antibody in humans. Cancer Res., 47: 3328-3336, 1987.
8. Thomas, G. D., Chappell, M. J., Dykes, P. W., Ramsden, D. B., Godfrey, K. R., Ellis, J. R. M., and Bradwell, A. R. Effect of dose, molecular size, affinity, and protein binding on tumor uptake of antibody or ligand: a biomalhematical model. Cancer Res., 49: 3290-3296. 1989.
9. Sung. C., Youle. R. J., and Dedrick, R. I Pharmacokinetic analysis of immunotoxin uptake in solid tumors: role of plasma kinetics, capillary permeability, and binding. Cancer Res., 50: 7382-7392, 1990.
10. Jain. R. K., and Baxter. L. T. Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure. Cancer Res., 48: 7022-7032, 1988.
11. Baxter. L. T., and Jain. R. K. Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection. Microvasc. Res., 37: 77-104, 1989.
12. Baxter, L. T., and Jain, R. K. Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics. Microvasc. Res., 40:246-263. 1990.
13. Baxter. L. T., and Jain. R. K. Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism. Microvasc. Res., 41: 5-23, 1991.
14. Baxter, L. T., and Jain, R. K. Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution. Microvasc. Res., 41: 252-272, 1991.
15. Fujimori. K., Covell. D. G., Fletcher. J. E., and Weinstein, J. N. Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in tumors. Cancer Res., 49: 5656-5663, 1989.
16. Le Doussal, J. M., Gruaz-Guyon, A., Martin, M., Gautherot. E., Delaage, M., and Barbet, J. Targeting of indium 111-labeled bivalent hapten to human melanoma mediated by bispecific monoclonal antibody conjugates: imaging of tumors hosted in nude mice. Cancer Res., 50: 3445-3452. 1990.
17. Blasberg. R. G., Nakagawa. H., Bourdon, M. A., Groothuis, D. R., Patlak, C. S., and Bigner, D. D. Regional localization of a glioma-associated antigen defined by monoclonal antibody 81C6 in viro: kinetics and implications for diagnosis and therapy. Cancer Res., 47: 4432-4443, 1987.
18. Goodwin. D. A., Meares, C. F., David, G. F., McTigue, M., McCall, M. J., Frincke, J. M., Stone. M. R., Bartholomew, R. M., and Leung, J. P. Monoclonal antibodies as reversible equilibrium carriers of radiopharmaceuticals. Nuca. Med. Biol., 13: 383-391, 1986.
19. Jain. R. K. Transport of molecules across tumor vasculature. Cancer Metas tasis Rev., 6: 559-593, 1987.
20. Humas, D., and Guette, E. L. Morphometric analyses of the tnicrovasculature of tumors during growth and after X-irradiation. Cancer (Phila.), 33: 103-110. 1974.
21. Nielsen, N. M., and Bundgaard, H. Glycolamide esters as biolabile prodrugs of carboxylic acid agents: synthesis, stability, bioconversion, and physicochemical properties. J. Pharm. Sci., 77: 285-298. 1988.
22. Gerlowski, L. E., and Jain. R. K. Microvascular permeability of normal and neoplastic tissues. Microvasc. Res., 31: 288-305. 1986. IMSL Problem-solving Software Systems, Version 1.0. IMSL Inc., Houston, 1987.
23. Stella. V. J., and Himmelstein, K. J. Prodrugs and site-specific drug delivery. J. Med. Chem., 23: 1275-1282. 1980.
24. Goodwin, D. A., Meares, C. F., McCall. M. J., McTigue, M., and Chaovapong, W. Pre-targeted immunoscintigraphy of murine tumors with indium 111-labeled bifunctional haptens. J. Nuca. Med., 29: 226-234, 1988.
25. Le Doussal, J. M., Martin, M., Gautherot, E., Delaage. M., and Barbet, J. In vitro and in vivo targeting of radiolabelcd monovalent and divalent haptens with dual specificity monoclonal antibody conjugates: enhanced divalent hapten affinity for cell-bound antibody conjugate. J. Nuca. Med., JO: 1358-1366, 1989.