1-(Carboxybenzyl)imidazole-5-acrylic Acids: Potent and Selective Angiotensin II Receptor Antagonists

Journal of Medicinal Chemistry

Volumn 34, Issue 4, 1991, Pages 1514-1517

  Weinstock, Joseph ^a   Keenan, Richard M ^a   Finkelstein, Joseph A ^a   Franz, Robert G ^a   Gaitanopoulos, Dimitri E ^a   Girard, Gerald R ^a   Gleason, John G ^a   Hill, David T ^a   Morgan, Tina M ^a   Aiyar, Nambi ^a   Brooks, David P ^a   Fredrickson, Todd A ^a   Ohlstein, Eliot H ^a   Raffolo, Robert R ^a   Stack, Elwood J ^a   Sulpizio, Anthony C ^a   Weidley, Edwin F ^a   Edwards, Richard M ^a   Hempel, Judith ^a   Peishoff, Catherine E ^a   Samanen, James ^a   more..

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 BUTYL 1 (4 CARBOXYBENZYL) 5 IMIDAZOLYL] 2 (2 THENYL) 2 PROPENOIC ACID; ACRYLIC ACID DERIVATIVE; ANGIOTENSIN; ANGIOTENSIN ANTAGONIST; ANGIOTENSIN RECEPTOR; EPROSARTAN; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY; BLOOD PRESSURE; DOG; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; INTRAVENOUS DRUG ADMINISTRATION; LETTER; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ACRYLATES; ANGIOTENSIN II; ANIMALS; AORTA; BLOOD PRESSURE; DOGS; IMIDAZOLES; INDICATORS AND REAGENTS; KIDNEY; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; MUSCLE, SMOOTH, VASCULAR; RABBITS; RATS; RECEPTORS, ANGIOTENSIN; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; VASOCONSTRICTION;

EID: 0025879914     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00108a043     Document Type: Article

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