Comparison of the effects of the novel vasodilator FK409 with those of nitroglycerin in isolated coronary artery of the dog

British Journal of Pharmacology

Volumn 103, Issue 3, 1991, Pages 1713-1718

  Yamada, Hiroaki ^a   Yoneyama, Fumiya ^a   Satoh, Keisuke ^a   Taira, Norio ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

cross tolerance; cyclic GMP; dog coronary artery; FK409; nitroglycerin; self tolerance

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 4 ETHYL 2 HYDROXYIMINO 5 NITRO 3 HEXENAMIDE; CYCLIC AMP; CYCLIC GMP; GLYCERYL TRINITRATE; METHYLENE BLUE; PHOSPHODIESTERASE INHIBITOR; VASODILATOR AGENT; ZAPRINAST;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY DILATATION; CROSS TOLERANCE; DOG; DRUG TOLERANCE; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; 3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMAL; COMPARATIVE STUDY; CORONARY VESSELS; DOGS; FEMALE; GUANYLATE CYCLASE; IN VITRO; MALE; METHYLENE BLUE; MUSCLE RELAXATION; NITRO COMPOUNDS; NITROGLYCERIN; PROSTAGLANDIN ENDOPEROXIDES, SYNTHETIC; PURINONES; SUPPORT, NON-U.S. GOV'T; VASODILATOR AGENTS;

EID: 0025876523     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1991.tb09852.x     Document Type: Article

References (18)

1. Regional mycoardial blood flow, ischemia, and antianginal drugs
2. Relationship between relaxation and cyclic GMP formation caused by nicorandil in canine mesenteric artery
3. Mechanisms of nitrate action and vascular tolerance
4. Determinants of in vitro nitroglycerin tolerance induction and reversal: influence of dose regimen, nitrate‐free period, and sulfhydryl supplementation
5. FK409, a novel vasodilator isolated from the acid‐treated fermentation broth of Streptomyces griseosporeus. I. Taxonomy, fermentation, isolation, and physico‐chemical and biological characteristics
6. Recent developments in nitrate therapy of ischaemic heart disease
7. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S‐nitrosothiols as active intermediates
8. Mechanisms of nitrate tolerance: a review
9. Evidence for cyclic GMP‐mediated relaxant effects of nitrocompounds in coronary smooth muscle
10. Selective blockade of endothelium‐dependent and glyceryl trinitrate‐induced relaxation by hemoglobin and by methylene blue in the rabbit aorta
11. Evidence for the inhibitory role of guanosine 3′,5′‐monophosphate in ADP‐induced human platelet aggregation in the presence of nitric oxide and related vasodilators
12. Comparative vasorelaxing profiles of nicorandil, isosorbide dinitrate and nitroglycerin in isolated coronary arteries of the dog
13. Prevention and reversal of nitrate tolerance in patients with congestive heart failure
14. Pharmacological estimation of drug‐receptor dissociation constants. Statistical evaluation. I. Agonists
15. Cardiovascular profile of FR900409, a newly synthesized vasodilator, in isolated dog vascular preparations and in anesthetized dogs and rats
16. Inhibition of platelet function by organic nitrate vasodilators
17. Role of cyclic GMP of canine vascular smooth muscle in relaxation by organic nitrates
18. Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B22,948, MY‐5445, vinpocetine and 1‐methyl‐3‐isobutyl‐8‐(methylamino)xanthine