Influence of age on the responsiveness of the gonadotrophs to luteinizing hormone-releasing hormone in males

Journal of Clinical Endocrinology and Metabolism

Volumn 72, Issue 6, 1991, Pages 1255-1260

  Kaufman, J M ^a   Giri, M ^a   Deslypere, J M ^a   Thomas, G ^a,b   Vermeulen, A ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b HÔPITAL FERNAND WIDAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN; LUTEINIZING HORMONE;

ADULT; AGED; AGING; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; HUMAN; IMMUNOREACTIVITY; INTRAVENOUS DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL;

ADULT; AGED; AGING; BASOPHILS; BIOLOGICAL ASSAY; DOSE-RESPONSE RELATIONSHIP, DRUG; GONADORELIN; GONADOTROPINS; HUMAN; IMMUNORADIOMETRIC ASSAY; MALE; MIDDLE AGE; PITUITARY GLAND, ANTERIOR; SUPPORT, NON-U.S. GOV'T;

EID: 0025873951     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jcem-72-6-1255     Document Type: Article

References (21)

1. Winters SJ, Troen P. Episodic luteinizing hormone (LH) secretion and the response of LH and follicle-stimulating hormone to LH-releasing hormone in aged men: evidence for coexistent primary testicular insufficiency and an impairment in gonadotropin secretion. J Clin Endocrinol Metab. 1982;55:560-5.
2. Winters SJ, Sherins RJ, Troen P. The gonadotropin-suppressive activity of androgen is increased in elderly men. Metabolism. 1984;33:1052-9.
3. Warner BA, Dufau ML, Santen RJ. Effects of aging and illness on the pituitary testicular axis in men: qualitative as well as quantitative changes in luteinizing hormone. J Clin Endocrinol Metab. 1985;60:263-8.
4. Montanini V, Simoni M, Chiossi G, et al. Pulsatile luteinizing hormone secretion in elderly men. In: Vezzadini P, Facchini A, Labo G, eds. Neuroendocrine system and aging. Paris; Eurage; 1986;121-6.
5. Deslypere JP, Kaufman JM, Vermeulen T, Vogelaers D, Vandalem JL, Vermeulen A. Influence of age on pulsatile luteinizing hormone release and responsiveness of the gonadotrophs to sex hormone feedback in men. J Clin Endocrinol Metab. 1987;64:68-73.
6. Tenover JS, Matsumoto AM, Clifton DK, Bremner WJ. Age related alterations in the circadian rhythms of pulsatile luteinizing hormone and testosterone secretion in healthy men. J Gerontol. 1988;43:M163-8.
7. Vermeulen A, Deslypere JP, Kaufman JM. Influence of antiopioids on luteinizing hormone pulsatility in aging men. J Clin Endocrinol Metab. 1989;68:68-72.
8. Urban RJ, Veldhuis JD, Blizzard RM, Dufau ML. Attenuated release of biologically active luteinizing hormone in healthy aging men. J Clin Invest. 1988;81:1020-9.
9. Van Damme M-P, Robertson DM, Diczfalusy E. An improved in vitro bio-assay method for measuring luteinizing hormone (LH) activity using mouse Leydig cell preparations. Acta Endocrinol (Copenh). 1974;77:655-71.
10. Cutler DJ. Numerical deconvolution by least squares: use of prescribed input functions. J Pharmacokinet Biopharmacol. 1978;6:227-41.
11. Baker HWG, Burger HG, de Kretser DM, Hudson B. Endocrinology of aging: pituitary testicular axis. Proc of the 5th Congr of Endocrinol. 1977;2:479-85.
12. Rubens R, Dhont M, Vermeulen A. Further studies on Leydig cell function in old age. J Clin Endocrinol Metab. 1979;39:40-8.
13. Harman SM, Tsitouras PD, Costa PT, Blackman MR. Reproductive hormones in aging men. II. Basal gonadotropins and gonadotropin responses to luteinizing hormone releasing hormone. J Clin Endocrinol Metab. 1982;54:547-51.
14. Veldhuis JM, Johnson ML. In vivo dynamics of luteinizing hormone secretion and clearance in man: assessment by deconvolution mechanics. J Clin Endocrinol Metab. 1988;66:1291-300.
15. Veldhuis JD, Johnson ML, Dufau ML. Preferential release of bioactive luteinizing hormone in response to endogenous and low dose exogenous gonadotropin-releasing hormone pulses in man. J Clin Endocrinol Metab. 1987;64:1275-82.
16. Tenover JS, Matsumoto AM, Plymate SR, Bremner WJ. The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: response to clomiphene citrate. J Clin Endocrinol Metab. 1987;65:1118-26.
17. Tsatsoulis A, Shalet SM, Richardson P, Robertson PW. Testosterone reduces the bioactivity of luteinizing hormone (LH) in man. Clin Endocrinol (Oxf). 1990;32:73-82.
18. Veldhuis JD, Dufau M. Estradiol modulates the pulsatile secretion of biologically active luteinizing hormone in man. J Clin Invest. 1987;80:631-8.
19. Jaakkola R, Ding YQ, Kellokumpu-Lehtinen P, et al. The ratios of serum bioactive/immunoreactive luteinizing hormone and follicle-stimulating hormone in various clinical conditions with increased and decreased gonadotropin secretion: réévaluation by a highly sensitive immunometric assay. J Clin Endocrinol Metab. 1990;70:1496-505.
20. Veldhuis JD, Carlson ML, Johnson ML. The pituitary gland secretes in bursts: appraising in the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. Proc Natl Acad Sci USA. 1987;84:7686-90.
21. Veldhuis JD, Fraioli F, Fogol AD, Dufau ML. Metabolic clearance of biologically active luteinizing hormone in man. J Clin Invest. 1986;77:1122-8.