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Bioorganic and Medicinal Chemistry Letters
Volumn 1, Issue 1, 1991, Pages 39-42
The synthesis and structural characterization of way-120,491; a novel potassium channel activator
Author keywords

[No Author keywords available]
Indexed keywords

ANTIHYPERTENSIVE AGENT; CELIKALIM;
EID: 0025864964     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)81086-6     Document Type: Article
Times cited : (21)
References (24)
  • 10
    • 0025015260 scopus 로고
    • Significant acid catalyzed epoxide opening occurs in the absence of buffer; however, MCPBA without buffer has been used recently with severely electron deficient chromenes:
    • (1990) J. Med. Chem. , vol.33 , pp. 492
    • Bergmann1    Gericke2
  • 17
    • 84912884491 scopus 로고    scopus 로고
    • 2 / hexane / ethyl acetate (6 / 6 / 1).
  • 19
    • 84912892942 scopus 로고    scopus 로고
    • w = 0.076.
  • 20
    • 0043123741 scopus 로고
    • A novel type of intramolecular Diels-Alder reaction involving dienol ethers: an unusual preference for a boat transition state in the incipient ring formation
    • For an example of an aryl acyltriflate preparation and coupling, see
    • (1984) The Journal of Organic Chemistry , vol.49 , pp. 3875
    • Koreeda1    Brown2
  • 21
    • 84912886005 scopus 로고    scopus 로고
    • 4)., and concentrated to give 98.4 (88% yield) of crude product. Pure ester 21 was isolated by trituration with hexane. Pure 22 is obtained by HPLC separation using 2% t-BuOMe / hexane elution.
  • 23
    • 84912854073 scopus 로고    scopus 로고
    • The enantiomeric purity of 23 was determined as the benzamide derivative by HPLC using a Chiracel OD column with 7% isopropanol / hexane eluiton.
  • 24
    • 84912886567 scopus 로고    scopus 로고
    • This resolution with L-tartartic acid, as well as other classical chiral resolving acids, initailly failed in the absence of authentic seed crystals.

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.