Cell proliferation and cytokine production by CD4+ cells from old mice

Journal of Cellular Biochemistry

Volumn 46, Issue 4, 1991, Pages 312-320

  Hobbs, Monte V ^a   Ernst, David N ^a   Torbett, Bruce E ^b   Glasebrook, Andrew L ^c   Rehse, Mark A ^a   McQuitty, Donald N ^a   Thoman, Marilyn L ^a   Bottomly, Kim ^d   Rothermel, Annette L ^a   Noonan, Daniel J ^e   Weigle, William O ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b University of California San Diego Medical Biology Institute   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e LIGAND PHARMACEUTICALS INC   (United States)

Author keywords

3G11; 6C10; aging; CD44; CD45RB; IFN ; IL 2; IL 4; T cells

Indexed keywords

CD4 ANTIGEN; CYTOKINE;

AGED; AGING; ANIMAL CELL; ARTICLE; CELL GROWTH; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

AGING; ANIMAL; ANTIGENS, CD; ANTIGENS, CD4; ANTIGENS, CD45; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; COMPARATIVE STUDY; CYTOKINES; HISTOCOMPATIBILITY ANTIGENS; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED STRAINS; RECEPTORS, LYMPHOCYTE HOMING; SPECIFIC PATHOGEN-FREE ORGANISMS; SPLEEN;

EID: 0025861263     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.240460406     Document Type: Article

References (49)

1. Immunological studies of aging. IX. Impaired proliferation of T lymphocytes detected in elderly humans by flow cytometry.
2. Reduced proliferation in T lymphocytes in aged humans is predominantly in the CD8+ subset, and is unrelated to defects in transmembrane signaling which are predominantly in the CD4+ subset
3. Age-related changes in human lymphocyte subsets: Progressive reduction of the CD4 CD45R (suppressor inducer) population