Serum concentrations of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and test results from selected residents of seveso, italy

Journal of Toxicology and Environmental Health

Volumn 32, Issue 4, 1991, Pages 357-366

  Mocarelli1, Paolo ^a,b   Needham, Larry L ^c   Marocchi, Alessandro ^b   Patterson, Donald G ^c   Brambilla, Paolo ^b   Gerthoux, Pier Mario ^b   Meazza, Luigi ^d   Carreri, Vittorio ^d  

^a UNIVERSITY OF MILAN   (Italy)

^b DESIO HOSPITAL   (Italy)

^c Centers for Disease Control ^*  (Georgia)

^d Regional Health Ministry   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN;

ADULT; ARTICLE; CHLORACNE; FEMALE; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; POPULATION EXPOSURE; PRIORITY JOURNAL; TOXICOKINETICS;

ACCIDENTS; ACNE VULGARIS; ADOLESCENT; ADULT; AGED; CHEMICAL INDUSTRY; CHILD; CHILD, PRESCHOOL; ENVIRONMENTAL EXPOSURE; FEMALE; FOLLOW-UP STUDIES; HUMANS; ITALY; MALE; MIDDLE AGED; TETRACHLORODIBENZODIOXIN;

EID: 0025859069     PISSN: 00984108     EISSN: None     Source Type: Journal    
DOI: 10.1080/15287399109531490     Document Type: Article

References (27)

1. Andrews, J. S., Jr., Garrett, W. A., Jr., Patterson, D. G., Jr., Needham, L. L., Roberts, D. W., Bagby, J. R., Anderson, J. E., Hoffman, R. E., and Schramm, W. 1990. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin levels In adipose tissue of persons with no known exposure and in exposed persons. Chemos- phere 18:499-506.
2. Beck, H., Eckart, K., Mather, W, Wittkowski, R. 1989. Levels of PCDDs and PCDFs in adipose tissue of occupationally exposed workers. Chemosphere 18:507-516.
3. Bertazzi, P. A., Zocchetti, C., Pesatori, A. C., Guercilena, S., Sanarico, M., and Radice, L. 1989. Ten- year mortality study of population involved in the Seveso incident in 1976. Am. J. Epidemiol.6:1187-1200.
4. Caramaschi, F., Del Corno, G., Favaretti, C, Giambelluca, S. E., Montesarchio, E., and Fara, G. M. 1981. Chloracne following environmental contamination by TCDD in Seveso, Italy. Int. J. Epi-demiol. 10:135-143.
5. Centers for Disease Control. 1988. Preliminary report: 2, 3, 7, 8-Tetra-chlorodibenzo-p-dioxin exposure to humans-Seveso, Italy. Morbid. Mortal. Weekly Rep. 37:733-36.
6. Cerlesi, S., Di Domenico, A., and Ratti, S. 1989. Recovery yields of early analytical procedures to detect 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) in soil samples at Seveso, Italy. Chemos-phere 18:989-1003.
7. De Carli, L., Mottura, A., Nuzzo, F., et al., 1982. Cytogenetic investigations of the Seveso population exposed to TCDD. In Plans for Clinical and Epidemiological Follow-Up after Area-Wide Chemi-cal Contamination: Proceedings of an International Workshop, eds. L. Dardanoni and R. W. Miller, pp. 292-317. Washington, D.C.: National Academy Press, National Academy of Sciences.
8. European Economic Communities. 1977. Report of the 1st Chloracne Panel, Milan, July 11-12. Document 2669/2/77.
9. Facchetti, S., Fornari, A., and Montagna, M. 1981. Distribution of 2, 3, 7, 8-tetrachlorodibenzo-p- dioxin in the tissues of a person exposed to the toxic cloud at Seveso. Forens. Environ. Appl.1:1406-44.
10. Fingerhut, M. A., Sweeney, M. H., Patterson, D. G., Jr., Piacitelli, L. A., Morris, J. A., Marlow, D. A., Horning, R. W., Cameron, L. W., Connally, L. B., Needham, L. L., and Halperin, W. E. 1989. Levels of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in the serum of U.S. chemical workers exposed to dioxin-contaminated products: Interim results. Chemosphere 19:835-840.
11. Gianotti, F. 1977. Chloracné au tetrachloro-2, 3, 7, 8-dibenzo-p-dioxine chez les enfants. Ann. Dermatol. Venereol. 104:825-29.
12. Ideo, G. 1981. Liver disease. Presented at Five Years of Epidemiologic Studies in Seveso Area, Milan, Italy, November 14.
13. Kimbrough, R. D. 1990. How toxic is 2, 3, 7, 8-tetrachlorodibenzodioxin to humans? J. Toxicol. Envi-ron. Health 30:261-271.
14. Leung, H. W., Wendling, J. M., Orth, R., Hileman, F., and Paustenbach, D. J. 1990. Relative distribution of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in human hepatic and adipose tissues. Toxicol. Lett. 50:275-282.
15. Mastroiacovo, P., Spagnolo, A., Marni, E., Meazza, L., Bertollini, R., and Segni, G. 1988. Birth defects in the Seveso area after TCDD contamination. J. Am. Med. Assoc. 259:1668-1672.
16. Mocarelli, P., Marocchi, A., Brambilla, P., Gerthoux, P., Young, D. S., and Mantel, N. 1986. Clinical laboratory manifestations of exposure to dioxin in children, a six-year study of the effects of an environmental disaster near Seveso, Italy. J. Am. Med. Assoc. 256:2687-2695.
17. Mocarelli, P., Marocchi, A., Brambilla, P., Gerthoux, P., Beretta, C, Columbo, L., Bertona, M., Sarto, C., Tramacere, P., Mondonico, A., Crespi, C., and Brivio, R. 1991. Effects of acute and chronic exposure in humans to dioxin after a nine year follow-up at Seveso, Italy. JAMA, in press.
18. Nygren, M., Rappe, C., and Lindstrom, G. 1986. Identification of 2, 3, 7, 8-substituted polychlorinated dioxins and dibenzofurans in environmental and human samples. In Chlorinated Dioxins and Dibenzfourans in Perspective, eds. C. Rappe, G. Choudhary, and L. Keith, pp. 17-34. Chelsea, Mich.: Lewis.
19. Patterson, D. G., Jr., Hampton, L., Lapeza, C. R., Jr., Belser, W. T., Green, V., Alexander, L., and Needham, L. L. 1987. High-resolution gas chromatographic/high-resolution mass spectromet- ric analysis of human serum on a whole-weight and lipid basis for 2378-tetrachlorodibenzo-p- dioxin. Anal. Chem. 59:2000-2005.
20. Patterson, D. G., Jr., Fingerhut, M. A., Roberts, D. W., Needham, L. L., Marlow, D. A., Sweeney, M. H., and Halperin, W. E. 1989. Levels of polychlorinated dibenzo-p-dioxins and dibenzofurans in workers exposed to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. Am.J. Ind. Med. 16:135-146.
21. Phillips, D. L., Pirkle, J. L., Burse, V. W., Steele, G. K., Needham, L. L., and Hannon, W. H. 1989. Chlorinated hydrocarbon levels in human serum: effects of fasting and feeding. Arch. Environ. Contam. Toxicol. 18:495-500.
22. Pirkle, J. L., Wolfe, W. M., Patterson, D. G., Jr., Needham, L. L., Michalek, J. E., Miner, J. C., Peterson, M. R., and Phillips, D. L. 1989. Estimates of the half-life of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in Vietnam veterans of Operation Ranch Hand. J. Toxicol. Environ. Health 27:165-171.
23. Pocchiari, F., Silano, V., and Zampieri, A. 1979. Human health effects from accidental release of tetrachlorodibenzo-p-dioxin (TCDD) at Seveso, Italy. Ann. N.Y. Acad. Sei. 320:311-320.
24. Schechter, A., and Ryan, J. J. 1988. PCDD and PCDF levels in human adipose tissues from workers 32 years after occupational exposure to 2, 3, 7, 8-TCDD in 1953 in Germany. Chemosphere17:915-920.
25. Sweeney, M. H., Fingerhut, M. A., Patterson, D. G., Jr., Connally, L. B., Piacitelli, L. A., Morris, J. A., Greife, A. L., Hornung, R. W., Maarlow, D. A., Dugle, J. E., Halperin, W. E., and Needham, L. L. 1990. Serum levels of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (2, 3, 7, 8-TCDD) in New Jersey and Missouri chemical workers exposed to dioxin contaminated processes: Interim report. Che-mosphere, 20:993-1000.
26. Webb, K. B., Evans, R. G., Knutsen, A. P., Roberts, D. W, Roodman, S. T., Schramm, W. F., Gibson, B. B., Andrews, J. S., Jr., Needham, L. L., and Patterson, D. R, Jr. 1989. Medical evaluation of subjects with known body levels of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. J. Toxicol. Environ. Health 28:183-193.
27. Zober, A., Messerer, R, and Huber, P. 1990. Thirty-four-year mortality follow-up of BASF employees exposed to 2, 3, 7, 8-TCDD after the 1953 accident. Int. Arch. Occup. Environ. Health 62:139-157.