The trk proto-oncogene encodes a receptor for nerve growth factor

Cell

Volumn 65, Issue 1, 1991, Pages 189-197

  Klein, Rüdiger ^a   Jing, Shugian ^a   Nanduri, Venkata ^a   O'Rourke, Edward ^a   Barbacid, Mariano ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NERVE GROWTH FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTO ONCOGENE; RAT;

ADRENAL GLAND NEOPLASMS; ANIMAL; CELL LINE; COMPARATIVE STUDY; GENE EXPRESSION; HUMAN; INSECTS; MICE; NERVE GROWTH FACTORS; PHEOCHROMOCYTOMA; PHOSPHORYLATION; PROTEIN-TYROSINE KINASE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENES; RATS; RECEPTOR, TRKA; RECEPTORS, CELL SURFACE; RECEPTORS, NERVE GROWTH FACTOR; SPECIES SPECIFICITY; TUMOR CELLS, CULTURED; TYROSINE;

ANIMALIA; INSECTA;

EID: 0025857391     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(91)90419-Y     Document Type: Article

References (45)

1. The trk family of tyrosine protein kinase receptors
2. Purification of a new neurotrophic factor from mammalian brain
3. High frequency of activation of tyrosine kinase oncogenes in human papillary thyroid carcinoma
4. Gene transfer and molecular cloning of the human NGF receptor
5. Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines
6. Effects of nerve growth factor on cholinergic brain neurons
7. Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells
8. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
9. Expression of functional nerve growth factor receptors after gene transfer
10. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family
11. Molecular characteristics of nerve growth factor receptors on PC12 cells
12. Murine sarcoma and leukemia viruses: assay using clonal lines of contactinhibited mouse cells
13. Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization
14. Expression and structure of the human NGF receptor
15. Molecular cloning of a human gene that is a member of the nerve growth factor family
16. trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development
17. The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain
18. Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system
19. Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products
20. Induction of the proto-oncogene fos by nerve growth factor
21. Structure and developmental expression of the nerve growth factor receptor in the chicken central nervous system
22. Molecular cloning and expression of brain-derived neurotrophic factor
23. The nerve growth factor: thirty-five years later
24. Purification, cloning, and expression of ciliary neurotrophic factor (CNTF)
25. Signals important for highlevel expression of foreign genes in Autographa californica nuclear polyhedrosis virus expression vectors
26. Nerve growth factor induces protein-tyrosine phosphorylation
27. Neurotrophin-3: a neurotrophic factor related to NGF and BDNF
28. A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences
29. Molecular and biochemical characterization of the human trk protooncogene
30. Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development
31. Identification of a nerve growth factor receptor protein in sympathetic ganglia membranes by affinity labeling
32. Nerve growth factor (NGF) induces neuronal differentiation in neuroblastoma cells transfected with the NGF receptor cDNA
33. Molecular investigations on the high-affinity nerve growth factor receptor
34. Structure and expression of the nerve growth factor gene
35. Introduction of nerve growth factor (NGF) receptors into a medulloblastoma cell line results in expression of high- and low-affinity NGF receptors but not NGF-mediated differentiation
36. Gene transfer and molecular cloning of the rat nerve growth factor receptor
37. Binding of brain-derived neurotrophic factor to the nerve growth factor receptor
38. Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor
39. A manual of methods for baculovirus vectors and insect cell culture procedures
40. Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells
41. Signal transduction by receptors with tyrosine kinase activity
42. Assaying binding of nerve growth factor to cell surface receptors
43. Evidence that biological activity of NGF is mediated through a novel subclass of high affinity receptors