-
1
-
-
0024518559
-
Antinuclear antibodies: Diagnostic markers for autoimmune diseases and probes for cell biology
-
Tan, E.M. 1989. Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv. Immunol. 44:93.
-
(1989)
Adv. Immunol.
, vol.44
, pp. 93
-
-
Tan, E.M.1
-
2
-
-
1842272312
-
Autoantibody to centromere (kinetochore) in scleroderma sera
-
Moroi, Y., C. Peebles, M.J. Fritzler, J. Steigerwald, and E.M. Tan. 1980. Autoantibody to centromere (kinetochore) in scleroderma sera. Proc Natl. Acad. Set. USA. 77:1627.
-
(1980)
Proc Natl. Acad. Set. USA.
, vol.77
, pp. 1627
-
-
Moroi, Y.1
Peebles, C.2
Fritzler, M.J.3
Steigerwald, J.4
Tan, E.M.5
-
4
-
-
0021044683
-
Centrosome development in early mouse embryos as defined by an autoantibody against pericen-triolar material
-
Callarco-Gillan, P.D., M.C. Siebert, R. Hubble, T. Mitchison, and M. Kirschner. 1983. Centrosome development in early mouse embryos as defined by an autoantibody against pericen-triolar material. Cell. 35:621.
-
(1983)
Cell.
, vol.35
, pp. 621
-
-
Callarco-Gillan, P.D.1
Siebert, M.C.2
Hubble, R.3
Mitchison, T.4
Kirschner, M.5
-
5
-
-
0000341684
-
Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus
-
Lerner, M.R., and J. A. Steitz. 1979. Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus. Proc Natl. Acad. Sci. USA. 76:5495.
-
(1979)
Proc Natl. Acad. Sci. USA.
, vol.76
, pp. 5495
-
-
Lerner, M.R.1
Steitz, J.A.2
-
6
-
-
0023196322
-
Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen
-
Earnshaw, W.C., K.F. Sullivan, P.S. Macklin, CA. Cooke, D.A. Kaiser, T.D. Pollard, N.F. Rothfield, andD.W. Cleveland. 1987. Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen. J. Cell Biol. 104:817.
-
(1987)
J. Cell Biol.
, vol.104
, pp. 817
-
-
Earnshaw, W.C.1
Sullivan, K.F.2
Macklin, P.S.3
Cooke, C.A.4
Kaiser, D.A.5
Pollard, T.D.6
Rothfield, N.F.7
Cleveland, D.W.8
-
7
-
-
0023036071
-
Cloning of the human cDNA for the Ul RNA-associated 70 K protein
-
Theissen, H., M. Etzerodt, R. Reuter, C. Schneider, F. Lott-speich, P. Argos, R. Lurhmann, and L. Philipson. 1986. Cloning of the human cDNA for the Ul RNA-associated 70 K protein. EMBO (Eur. Mol. Biol. Organ.) J. 5:3209.
-
(1986)
EMBO (Eur. Mol. Biol. Organ.) J.
, vol.5
, pp. 3209
-
-
Theissen, H.1
Etzerodt, M.2
Reuter, R.3
Schneider, C.4
Lott-speich, F.5
Argos, P.6
Lurhmann, R.7
Philipson, L.8
-
8
-
-
0023603553
-
The human U1-70K protein: CDNA cloning, chromosomal localization, expression, alternative splicing, and RNA-binding
-
Spritz, R.A., K. Strunk, CS. Surowy, S.O. Hoch, D.E. Barton, and U. Francke. 1987. The human U1-70K protein: cDNA cloning, chromosomal localization, expression, alternative splicing, and RNA-binding. Nucleic Acids Res. 15:10373.
-
(1987)
Nucleic Acids Res.
, vol.15
, pp. 10373
-
-
Spritz, R.A.1
Strunk, K.2
Surowy, C.S.3
Hoch, S.O.4
Barton, D.E.5
Francke, U.6
-
9
-
-
0023478466
-
Molecular cloning of the human Ul snRNA-associated A protein: Extensive homology between Ul and U2 snRNP-specific proteins
-
Sillekens, P.T.G., R.P. Beijer, W.J. Habets, and W.J. Van Venr-roij. 1987. Molecular cloning of the human Ul snRNA-associated A protein: extensive homology between Ul and U2 snRNP-specific proteins. EMBO (Eur. Mol. Biol. Organ.) J. 6:3841.
-
(1987)
EMBO (Eur. Mol. Biol. Organ.) J.
, vol.6
, pp. 3841
-
-
Sillekens, P.T.G.1
Beijer, R.P.2
Habets, W.J.3
Van Venr-roij, W.J.4
-
10
-
-
0023316809
-
Analysis of a cDNA clone expressing a human autoimmune antigen: Full-length sequence of the U2 small nuclear RNA-associated B" antigen
-
Habets, W.J., P.T.G. Sillekens, M.H. Hoet, J.A. Schalken, A.J.M. Roebroek, J.A.M. Lennissen, W.J.M. Van de Ven, and W.J. Van Venrooij. 1987. Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen. Proc Natl. Acad. Sci. USA. 84:2421.
-
(1987)
Proc Natl. Acad. Sci. USA.
, vol.84
, pp. 2421
-
-
Habets, W.J.1
Sillekens, P.T.G.2
Hoet, M.H.3
Schalken, J.A.4
Roebroek, A.J.M.5
Lennissen, J.A.M.6
Van De Ven, W.J.M.7
Van Venrooij, W.J.8
-
12
-
-
0023779379
-
The complete primary structure of the human snRNP E protein
-
Stanford, D.A., M. Kehl, C.A. Perry, E.L. Holicky, S.E. Harvey, A.M. Rohleder, K. Rehder Jr., R. Luhrmann, and E.D. Wieben. 1988. The complete primary structure of the human snRNP E protein. Nucleic Acids Res. 16:10593.
-
(1988)
Nucleic Acids Res.
, vol.16
, pp. 10593
-
-
Stanford, D.A.1
Kehl, M.2
Perry, C.A.3
Holicky, E.L.4
Harvey, S.E.5
Rohleder, A.M.6
Rehder, K.7
Luhrmann, R.8
Wieben, E.D.9
-
13
-
-
0024708696
-
Sjögren’s syndrome nuclear antigen B(La): CDNA cloning, structural domains, and autoepitopes
-
Chan, E.K.L., K.F. Sullivan, R.L. Fox, and E.M. Tan. 1989. Sjögren’s syndrome nuclear antigen B(La): cDNA cloning, structural domains, and autoepitopes. J. Autoimmunity. 2:321.
-
(1989)
J. Autoimmunity.
, vol.2
, pp. 321
-
-
Chan, E.K.L.1
Sullivan, K.F.2
Fox, R.L.3
Tan, E.M.4
-
14
-
-
0024524260
-
Ribonu-cleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding
-
Chan, E.K.L., K.F. Sullivan, and E.M. Tan. 1989. Ribonu-cleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding. Nucleic Acids Res. 17:2233.
-
(1989)
Nucleic Acids Res.
, vol.17
, pp. 2233
-
-
Chan, E.K.L.1
Sullivan, K.F.2
Tan, E.M.3
-
16
-
-
0024524337
-
Isolation and characterization of a cDNA clone encoding the 60-kDa component of the human SS-A/Ro ribonucleoprotein autoantigen
-
Ben-Chetrit, E., BJ. Gandy, E.M. Tan, and K.F. Sullivan. 1989. Isolation and characterization of a cDNA clone encoding the 60-kDa component of the human SS-A/Ro ribonucleoprotein autoantigen. J. Clin. Invest. 83:1284.
-
(1989)
J. Clin. Invest.
, vol.83
, pp. 1284
-
-
Ben-Chetrit, E.1
Gandy, B.J.2
Tan, E.M.3
Sullivan, K.F.4
-
17
-
-
0014949207
-
Cleavage of structural protein during assembly of the head of bacteriophage T4
-
Laemmli, U.K. 1970. Cleavage of structural protein during assembly of the head of bacteriophage T4. Nature (Land.). 227:680.
-
(1970)
Nature (Land.).
, vol.227
, pp. 680
-
-
Laemmli, U.K.1
-
18
-
-
0021235767
-
Preparation of nuclear matrices from cultured cells: Subfractionation of nuclei in situ
-
Staufenbiel, M., and W. Deppert. 1984. Preparation of nuclear matrices from cultured cells: subfractionation of nuclei in situ. J. Cell Biol. 98:1886.
-
(1984)
J. Cell Biol.
, vol.98
, pp. 1886
-
-
Staufenbiel, M.1
Deppert, W.2
-
19
-
-
0023900161
-
Immunolocalization of the 7-2 ribonucleoprotein in the granular component of the nucleolus
-
Reimer, G., I. Raska, U. Scheer, and E.M. Tan. 1988. Immunolocalization of the 7-2 ribonucleoprotein in the granular component of the nucleolus. Exp. Cell Res. 176:117.
-
(1988)
Exp. Cell Res.
, vol.176
, pp. 117
-
-
Reimer, G.1
Raska, I.2
Scheer, U.3
Tan, E.M.4
-
20
-
-
0001617063
-
Efficient isolation of genes by using antibody probes
-
Young, R.A., and R.W. Davis. 1983. Efficient isolation of genes by using antibody probes. Proc Natl. Acad. Sci. USA. 80:1194.
-
(1983)
Proc Natl. Acad. Sci. USA.
, vol.80
, pp. 1194
-
-
Young, R.A.1
Davis, R.W.2
-
21
-
-
0019769456
-
Determination of nucleotide sequence in DNA
-
Sanger, F. 1981. Determination of nucleotide sequence in DNA. Science (Wash. DC). 214:1205.
-
(1981)
Science (Wash. DC).
, vol.214
, pp. 1205
-
-
Sanger, F.1
-
22
-
-
0020793569
-
A technique for radio-labelling DNA restriction endonuclease fragments to high specific activity
-
Feinberg, A.P., and B. Vogelstein. 1983. A technique for radio-labelling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132:6.
-
(1983)
Anal. Biochem.
, vol.132
, pp. 6
-
-
Feinberg, A.P.1
Vogelstein, B.2
-
23
-
-
0019877801
-
Affinity purification of antibodies from diazotized paper blots of heterogeneous protein samples
-
Olmsted, J.B. 1981. Affinity purification of antibodies from diazotized paper blots of heterogeneous protein samples. J. Biol Chem. 256:11955.
-
(1981)
J. Biol Chem.
, vol.256
, pp. 11955
-
-
Olmsted, J.B.1
-
24
-
-
0022766180
-
mRNA polyadenylate-binding protein: Gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence
-
Adam, S.A., T. Nakagawa, M.S. Swanson, T.K. Woodruff, and G. Dreyfuss. 1986. mRNA polyadenylate-binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence. Mol. Cell. Biol. 6:2932.
-
(1986)
Mol. Cell. Biol.
, vol.6
, pp. 2932
-
-
Adam, S.A.1
Nakagawa, T.2
Swanson, M.S.3
Woodruff, T.K.4
Dreyfuss, G.5
-
25
-
-
0002953234
-
Enzyme-linked immunosorbent assay for anti-DNA and anti-histone antibodies
-
3rd ed. N.R. Rose, H. Friedman, and J.L. Fahey, editors. American Society for Microbiology, Washington, D.C
-
Rubin, R.L. 1986. Enzyme-linked immunosorbent assay for anti-DNA and anti-histone antibodies. In Manual of Clinical Laboratory Immunology. 3rd ed. N.R. Rose, H. Friedman, and J.L. Fahey, editors. American Society for Microbiology, Washington, D.C 744-748.
-
(1986)
Manual of Clinical Laboratory Immunology.
, pp. 744-748
-
-
Rubin, R.L.1
-
26
-
-
0001227249
-
Un sencillo metodo de coloration seletiva del reticulo protoplasmatico y sus efectos en los diversos organos nerviosos de vertebrados e invertebrados
-
Ramon Y Cajal, S. 1903. Un sencillo metodo de coloration seletiva del reticulo protoplasmatico y sus efectos en los diversos organos nerviosos de vertebrados e invertebrados. Tra. Lab. Invest. Biol. 2:129.
-
(1903)
Tra. Lab. Invest. Biol.
, vol.2
, pp. 129
-
-
Ramon Y Cajal, S.1
-
27
-
-
0020657537
-
The "accessory body" of Cajal in the neuronal nucleus. A light and electron microscopic approach
-
Lafarga, M., J.P. Hervas, M.C. Santa-Cruz, J. Villegas, and D. Crespo. 1983. The "accessory body" of Cajal in the neuronal nucleus. A light and electron microscopic approach. Anat. Embriol. 166:19.
-
(1983)
Anat. Embriol.
, vol.166
, pp. 19
-
-
Lafarga, M.1
Hervas, J.P.2
Santa-Cruz, M.C.3
Villegas, J.4
Crespo, D.5
-
28
-
-
0019904628
-
Localization of acid phosphatasic activity, phosphate ions and inorganic cations in plant nuclear coiled bodies
-
Moreno Diaz de la Espina, S., M.A. Sanchez-Pina, and M.C. Risueno. 1982. Localization of acid phosphatasic activity, phosphate ions and inorganic cations in plant nuclear coiled bodies. Cell Biol. Int. Rep. 6:601.
-
(1982)
Cell Biol. Int. Rep.
, vol.6
, pp. 601
-
-
Moreno Diaz De La Espina, S.1
Sanchez-Pina, M.A.2
Risueno, M.C.3
-
29
-
-
0014555462
-
The para-nucleolar structure, accessory body of Cajal, sex chromatin, and related structures in nuclei of rat trigeminal neurons: A cytochemical and ultrastructural study
-
Hardin, J.H., S.S. Spicer, and W.B. Greene. 1969. The para-nucleolar structure, accessory body of Cajal, sex chromatin, and related structures in nuclei of rat trigeminal neurons: a cytochemical and ultrastructural study. Anat. Rec 164:403.
-
(1969)
Anat. Rec
, vol.164
, pp. 403
-
-
Hardin, J.H.1
Spicer, S.S.2
Greene, W.B.3
-
30
-
-
0020407037
-
Argyro-philic proteins on coiled bodies in sympathetic neurons identified by Ag-NOR procedure
-
Seite, R., M-J. Pebusque, and M. Vio-Cigna. 1982. Argyro-philic proteins on coiled bodies in sympathetic neurons identified by Ag-NOR procedure. Biol. Cell. 46:97.
-
(1982)
Biol. Cell.
, vol.46
, pp. 97
-
-
Seite, R.1
Pebusque, M.-J.2
Vio-Cigna, M.3
-
31
-
-
0043167125
-
The role of plant coiled bodies in the nuclear RNA metabolism
-
Moreno Diaz de la Espina, S., A. Sanchez Pina, M.C. Risueno, F.J. Medina, and M.E. Fernandez-Gomez. 1980. The role of plant coiled bodies in the nuclear RNA metabolism. Electr. Microscopy. 2:240.
-
(1980)
Electr. Microscopy.
, vol.2
, pp. 240
-
-
Moreno Diaz De La Espina, S.1
Sanchez Pina, A.2
Risueno, M.C.3
Medina, F.J.4
Fernandez-Gomez, M.E.5
-
32
-
-
0022917629
-
IgM anti-histone H-3 antibody associated with undifferentiated rheumatic syndromes
-
Molden, D.P., G.L. Klipple, C.L. Peebles, R.L. Rubin, R.M. Nakamura, and E.M. Tan. 1986. IgM anti-histone H-3 antibody associated with undifferentiated rheumatic syndromes. Arthritis Rheum. 29:39.
-
(1986)
Arthritis Rheum.
, vol.29
, pp. 39
-
-
Molden, D.P.1
Klipple, G.L.2
Peebles, C.L.3
Rubin, R.L.4
Nakamura, R.M.5
Tan, E.M.6
-
33
-
-
0021349340
-
Diversity of autoantibodies in primary biliary cirrhosis and chronic active hepatitis
-
Bernstein, R.M., J.M. Neuberger, CC Bunn, M.E. Callender, G. R.V. Hughes, and R. Williams. 1984. Diversity of autoantibodies in primary biliary cirrhosis and chronic active hepatitis. Clin. Exp Immunol. 55:553.
-
(1984)
Clin. Exp Immunol.
, vol.55
, pp. 553
-
-
Bernstein, R.M.1
Neuberger, J.M.2
Bunn, C.C.3
Callender, M.E.4
Hughes, G.R.V.5
Williams, R.6
-
34
-
-
0023183665
-
Immunoglobulin G subclass distribution of autoantibodies in systemic sclerosis, primary biliary cirrhosis, and overlap syndromes
-
French, M.A.H., and R.M. Bernstein. 1987. Immunoglobulin G subclass distribution of autoantibodies in systemic sclerosis, primary biliary cirrhosis, and overlap syndromes. Ann. Rheum. Dis. 46:436.
-
(1987)
Ann. Rheum. Dis.
, vol.46
, pp. 436
-
-
French, M.A.H.1
Bernstein, R.M.2
-
35
-
-
0021815353
-
Immunomorphological characterization of antinuclear anti- bodies in chronic liver disease
-
Cassani, R, F.B. Bianchi, M. Lenzi, U. Volta, and E. Pisi. 1985. Immunomorphological characterization of antinuclear anti- bodies in chronic liver disease. J. Clin. Pathol. 38:801.
-
(1985)
J. Clin. Pathol.
, vol.38
, pp. 801
-
-
Cassani, R.1
Bianchi, F.B.2
Lenzi, M.3
Volta, U.4
Pisi, E.5
-
36
-
-
0021325492
-
Antinuclear antibodies in primary biliary cirrhosis
-
Powell, F., AX. Schroeter, and E.R. Dickson. 1984. Antinuclear antibodies in primary biliary cirrhosis. Lancet. i:288.
-
(1984)
Lancet.
, vol.1
, pp. 288
-
-
Powell, F.1
Schroeter, A.X.2
Dickson, E.R.3
-
37
-
-
0020068881
-
Association of antinuclear and antinucleolar antibodies in progressive systemic sclerosis
-
Bernstein, R.M., J.C Steigerwald, and E.M. Tan. 1982. Association of antinuclear and antinucleolar antibodies in progressive systemic sclerosis. Clin. Exp. Immunol 48:43.
-
(1982)
Clin. Exp. Immunol
, vol.48
, pp. 43
-
-
Bernstein, R.M.1
Steigerwald, J.C.2
Tan, E.M.3
-
38
-
-
0021364595
-
Speckled pattern antinuclear antibodies resembling anti-centromere antibodies
-
Fritzler, M.J., D.W. Valencia, and G.A. McCarty. 1984. Speckled pattern antinuclear antibodies resembling anti-centromere antibodies. Arthritis Rheum. 27:92.
-
(1984)
Arthritis Rheum.
, vol.27
, pp. 92
-
-
Fritzler, M.J.1
Valencia, D.W.2
McCarty, G.A.3
-
39
-
-
0023789539
-
A novel antinuclear antibody associated with a lupus-like paraneoplastic syndrome
-
Freundlich, B., D. Makover, and G.G. Maul. 1988. A novel antinuclear antibody associated with a lupus-like paraneoplastic syndrome. Ann. Intern. Med. 109:295.
-
(1988)
Ann. Intern. Med.
, vol.109
, pp. 295
-
-
Freundlich, B.1
Makover, D.2
Maul, G.G.3
-
40
-
-
0023232108
-
Monoclonal antibody from a (New Zealand Black × New Zealand White)Fl mouse and some human scleroderma sera target an Mr 34,000 nucleolar protein of the U3 RNP particle
-
Reimer, G., K.M. Pollard, CA. Penning, R.L. Ochs, M.A. Lischwe, H. Busch, and E.M. Tan. 1987. Monoclonal antibody from a (New Zealand Black × New Zealand White)Fl mouse and some human scleroderma sera target an Mr 34,000 nucleolar protein of the U3 RNP particle. Arthritis Rheum. 30:793.
-
(1987)
Arthritis Rheum.
, vol.30
, pp. 793
-
-
Reimer, G.1
Pollard, K.M.2
Penning, C.A.3
Ochs, R.L.4
Lischwe, M.A.5
Busch, H.6
Tan, E.M.7
-
41
-
-
0023395345
-
Structural analysis of the human U3 ribonucleoprotein particle reveal a conserved sequence available for base pairing with pre-rRNA
-
Parker, K.A., and J.A. Steitz. 1987. Structural analysis of the human U3 ribonucleoprotein particle reveal a conserved sequence available for base pairing with pre-rRNA. Mol. Cell Biol. 7:2899.
-
(1987)
Mol. Cell Biol.
, vol.7
, pp. 2899
-
-
Parker, K.A.1
Steitz, J.A.2
-
42
-
-
0019499146
-
A small nuclear ribonucleoprotein is required for splicing of adenoviral early RNA sequences
-
Yang, V.W., M.R. Lerner, J.A. Steitz, and S.J. Flint. 1981. A small nuclear ribonucleoprotein is required for splicing of adenoviral early RNA sequences. Proc Natl. Acad. Sci. USA. 78:1371.
-
(1981)
Proc Natl. Acad. Sci. USA.
, vol.78
, pp. 1371
-
-
Yang, V.W.1
Lerner, M.R.2
Steitz, J.A.3
Flint, S.J.4
-
43
-
-
0023288548
-
Splicing of messenger RNA precursors
-
Sharp, P.A. 1987. Splicing of messenger RNA precursors. Science (Wash. DC). 235:766.
-
(1987)
Science (Wash. DC).
, vol.235
, pp. 766
-
-
Sharp, P.A.1
-
44
-
-
0021334795
-
Ultrastructural distribution of a nuclear ribonucleoprotein as visualized by im-munocytochemistry on thin sections
-
Fakan, S., G. Leser, and T.E. Martin. 1984. Ultrastructural distribution of a nuclear ribonucleoprotein as visualized by im-munocytochemistry on thin sections. J. Cell Biol. 98:358.
-
(1984)
J. Cell Biol.
, vol.98
, pp. 358
-
-
Fakan, S.1
Leser, G.2
Martin, T.E.3
-
45
-
-
0021713053
-
Detection of intranuclear clusters of Sm antigens with monoclonal anti-Sm antibodies by immunoelectron microscopy
-
Eliceiri, G.L., and J.S. Ryerse. 1984. Detection of intranuclear clusters of Sm antigens with monoclonal anti-Sm antibodies by immunoelectron microscopy. J. Cell. Physiol. 121:449.
-
(1984)
J. Cell. Physiol.
, vol.121
, pp. 449
-
-
Eliceiri, G.L.1
Ryerse, J.S.2
-
46
-
-
0025615327
-
Association between the nucleolus and the coiled body
-
Raska, I., R.L. Ochs, L.E.C. Andrade, E.K.L. Chan, R. Burlin-game, C. Peebles, D. Gruol, and E.M. Tan. 1991. Association between the nucleolus and the coiled body. J. Structural Biol. 104:120.
-
(1991)
J. Structural Biol.
, vol.104
, pp. 120
-
-
Raska, I.1
Ochs, R.L.2
Andrade, L.E.C.3
Chan, E.K.L.4
Burlin-game, R.5
Peebles, C.6
Gruol, D.7
Tan, E.M.8
-
47
-
-
0023979999
-
Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation
-
Dreyfuss, G., M. Swanson, and S. Pinol-Roma. 1988. Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation. Trends Biochem. Sci. 13:86.
-
(1988)
Trends Biochem. Sci.
, vol.13
, pp. 86
-
-
Dreyfuss, G.1
Swanson, M.2
Pinol-Roma, S.3
-
49
-
-
0021760092
-
A comprehensive set of sequence analysis programs for the VAX
-
Deveraux, J., P. Haeberli, and O. Smithies. 1984. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12:387.
-
(1984)
Nucleic Acids Res.
, vol.12
, pp. 387
-
-
Deveraux, J.1
Haeberli, P.2
Smithies, O.3
|