Cyclosporin-mediated depression of luteinizing hormone receptors and heme biosynthesis in rat testes: A possible mechanism for decrease in serum testosterone

Endocrinology

Volumn 129, Issue 5, 1991, Pages 2647-2654

  Krueger, Beth A ^a   Trakshel, G Michael ^a   Sluss, Patrick M ^a   Maines, Mahin D ^a,b  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b Recipient of the Burroughs Wellcome Toxicology Scholar Award ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; FOLLITROPIN; HEME; LUTEINIZING HORMONE; LUTEINIZING HORMONE RECEPTOR; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STEROIDOGENESIS; SUBCUTANEOUS DRUG ADMINISTRATION; TESTIS;

ANIMAL; CYCLOSPORINE; CYTOCHROME P-450 ENZYME SYSTEM; FOLLICLE STIMULATING HORMONE; HEME; LUTEINIZING HORMONE; MALE; RATS; RATS, INBRED STRAINS; RECEPTORS, LH; STEROIDS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TESTIS; TESTOSTERONE;

EID: 0025838784     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/endo-129-5-2647     Document Type: Article

References (59)

1. Mason J 1989 Pathophysiology and toxicology of cyclosporin in humans and animals. Pharmacol Rev 41:423-434
2. Mason J 1990 Renal side-effects of cyclosporin. Transplant Proc 22:1280-1283
3. Schachter M 1988 Cyclosporine A and hypertension. J Hypertension 6:511-516
4. Koyle MA, Sikka SC, Rivera F, Lemmi CA, Conner J, Rajfer J 1986 Cyclosporin inhibits testosterone biosynthesis in the testis. Surg Forum 37:471-472
5. Rajfer J, Sikka SC, Lemmi C, Koyle MA 1987 Cyclosporin inhibits testosterone biosynthesis in the rat testis. Endocrinology 121:586-589
6. Seethalakshmi L, Menon M, Malhotra RR, Diamond DA 1987 Effect of cyclosporin A on male reproduction in rats. J Urol 138:991-995
7. Seethalakshmi L, Flores C, Khauli RB, Diamond DA, Menon M 1990 Evaluation of the effect of experimental cyclosporine toxicity on male reproduction and renal function. Transplantation 49:17-19
8. Sikka SC, Bhasin S, Coy DC, Koyle MA, Swerdloff RS, Rajfer J 1988 Effects of cyclosporine on the hypothalamic-pituitary-gonadal axis in the male rat: Mechanism of action. Endocrinology 123:1069-1074
9. Sikka SC, Coy DC, Lemmi CAE, Rajfer J 1988 Effect of cyclosporin on steroidogenesis in rat Leydig cells. Transplantation 46:886-889
10. Sikka SC, Koyle MA, Swerdloff RS, Rajfer J 1988 Reversibility of cyclosporin-induced hypoandrogenism in rats. Transplantation 45:784-787
11. Seethalakshmi L, Diamond DA, Malhotra RK, Mazanitis SC, Kumar S, Menon M 1988 Cyclosporin-induced testicular dysfunction: A separation of the nephrotoxic component and an assessment of a 60-day recovery period. Transplant Proc 20:1005-1010
12. Cavallini L, Malendowicz LK, Giuseppina G, Belloni AS, Nussdorfer GG 1990 Effects of prolonged cyclosporine-A treatment on the Leydig cells of the rat testis. Virchows Arch [Zellpathol] 58:215-220
13. Catt KJ, Harwood JP, Aguilera G, Dufau ML 1979 Hormonal regulation of peptide receptors and target cell responses. Nature 280:109-116
14. Cigorraga S, Dufau ML, Catt KJ 1978 Regulation of luteinizing hormone receptors and steroidogenesis in gonadotropin-desensi-tized Leydig cells. J Biol Chem 253:4297-4304
15. Nozu R, Matsuura S, Catt KJ, Dufau ML 1981 Modulation of Leydig cell androgen biosynthesis and cytochrome P-450 levels during estrogen treatment and human chorionic gonadotropin-induced desensitization. J Biol Chem 256:10012-10016
16. Payne AH 1990 Hormonal regulation of cytochrome P450 enzymes, cholesterol side chain cleavage and 17 alpha hydroxylase/C 17-20 lyase in Leydig cells. Biol Reprod 42:399-404
17. Hall PF 1986 Cytochromes P-450 and the regulation of steroid synthesis. Steroids 48:131-196
18. Maines MD, Sluss PM, Iscan M 1990 Cis-platinum-mediated depression of LH receptors and cytochrome P-450scc in rat Leydig cells: A possible mechanism for decrease in serum testosterone. Endocrinology 126:2398-2406
19. Maines MD 1990 Effect of cis-platinum on heme, drug and steroid metabolism pathways: Possible involvement in infertility and nephrotoxicity. CRC Crit Rev Toxicol 21:1-20
20. Nakajin S, Hall PF 1981 Microsomal cytochrome P-450 from neonatal pig testis. J Biol Chem 256:3871-3876
21. Nakajin S, Shinoda M, Haniu M, Shively JE, Hall PF 1984 C21 steroid side chain cleavage enzyme from porcine adrenal micro-somes. J Biol Chem 259:3971-3976
22. Yanase T, Kagimoto M, Matsui N, Simpson ER, Waterman MR 1988 Combined 17α-hydroxylase/17, 20-lyase deficiency due to a stop codon in the N-terminal region of 17α-hydroxylase cytochrome P-450. Mol Cell Endocrinol 59:249-253
23. Zuber MX, Simpson ER, Waterman MR 1986 Expression of bovine 17α-hydroxylase cytochrome P-450 cDNA in nonsteroidogenic (COS 1) cells. Science 234:1258-1261
24. Maines MD, Chung AS, Kutty RK 1982 Inhibition of testicular heme oxygenase activity by cadmium: A novel cellular response. J Biol Chem 257:14116-14121
25. Granick S 1966 The induction in vitro of the synthesis of δ-aminolevulinic acid synthetase in chemical porphyria: A response to certain drugs, sex hormones, and foreign chemicals. J Biol Chem 241:1359-1375
26. Mayer RD, Berman S, Cockett ATK, Maines MD 1989 Differential effects of cyclosporin on hepatic and renal heme, cytochrome P-450 and drug metabolism: Possible role in nephrotoxicity of the drug. Biochem Pharmacol 38:1001-1007
27. Ismail AAA, Niswender GD, Midgley Jr AR 1972 Radioimmunoassay of testosterone without chromatography. J Clin Endocrinol Metab 34:177-184
28. Maines MD, Jollie DR 1984 Dissociation of heme metabolic activities from the microsomal cytochrome P-450 turnover in testis of hypophysectomized rats. J Biol Chem 259:9557-9562
29. Omura T, Sato R 1964 The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J Biol Chem 239:2370-2378
30. Paul KC, Theorell H, Akeson A 1953 The molar light absorption of pyridine ferroprotoporphyrin. Acta Chem Scand 7:1284-1287
31. Granick S, Sinclair P, Sassa S, Grieninger G 1975 Effects by heme, insulin, and serum albumin on heme and protein synthesis in chick embryo liver cells cultured in a chemically defined medium, and a spectrofluorometric assay for porphyrin composition. J Biol Chem 250:9215-9225
32. Maines MD, Mayer RD 1985 Inhibition of testicular cytochrome P-450 dependent steroid biosynthesis by cis-platinum. J Biol Chem 260:6063-6068
33. Dehnen W, Tomingas R, Roos J 1973 A modified method for the assay of benzo(a)pyrene hydroxylase. Anal Biochem 53:373-383
34. Trakshel GM, Kutty RK, Maines MD 1986 Cadmium-mediated inhibition of testicular heme oxygenase activity: The role of NADPH-cytochrome c (P-450) reductase. Arch Biochem Biophys 251:175-187
35. Maines MD, Kappas A 1974 Cobalt induction of hepatic heme oxygenase; with evidence that cytochrome P-450 is not essential for this enzyme activity. Proc Natl Acad Sci USA 71:4293-4297
36. Strobel HW, Dignam JD 1978 Purification and properties of NADPH-cytochrome P-450 reductase. In: Fleischer S, Packer L (eds) Methods in Enzymology. Academic Press, New York, vol 52:89-96
37. Mason JI, Arthur JR, Boyd GS 1978 Control of steroid metabolism in rat adrenal mitochondria. Biochem J 174:1045-1051
38. Veltman JC, Maines MD 1986 Alterations of heme, cytochrome P-450, and steroid metabolism by mercury in rat adrenals. Arch Biochem Biophys 248:467-478
39. Abraham GE, Buster JE, Kyle FW, Corrales PC, Teller RC 1973 Radioimmunoassay of plasma pregnenolone. J Clin Endocrinol Metab 37:40-45
40. Maines MD 1980 Regional distribution of the enzymes of haem biosynthesis and the inhibition of δ-aminolevulinate synthetase by manganese in the rat brain. Biochem J 190:315-321
41. Mauzerall D, Granick S 1956 The occurance and determination of δ-aminolevulinic acid and porphobilinogen in urine. J Biol Chem 219:435-466
42. Granick S, Sassa S, Granick JL, Lever RD, Kappas A 1972 Assays for porphyrins, δ-aminolevulinc-acid dehydratase, and porphyri-nogen synthetase in microliter samples of blood: Applications to metabolic defects involving the heme pathway. Proc Natl Acad Sci USA 69:2381-2385
43. Jones MS, Jones OTG 1969 The structural organization of haem synthesis in rat liver mitochondria. Biochem J 113:507-514
44. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ 1951 Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275
45. Dufau ML, Baukal AJ, Catt KJ 1980 Hormone-induced guanyl nucleotide binding and activation of adenylate cyclase in the Leydig cell. Proc Natl Acad Sci USA 77:5837-5841
46. Nebert DW, Gonzalez FJ 1987 P-450 genes: Structure, evolution, and regulation. Annu Rev Biochem 56:945-993
47. Shemin D, Russell CS 1953 δ-Aminolevulinic acid, its role in the biosynthesis of porphyrines and purines. J Am Chem Soc 75:4873-4874
48. Neuberger A, Scott JJ 1953 Aminolaevulinic acid and porphyrin synthesis. Nature 172:1093-1094
49. Maines MD 1988 Heme oxygenase: Function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J 2:2557-2568
50. Taketani S, Tokunaga R 1981 Rat liver ferrochelatase purification, properties, and stimulation by fatty acids. J Biol Chem 256:12748-12753
51. Buss WC, Stepanek J, Bennett WM 1989 New proposal for the mechanism of cyclosporine A nephrotoxicity: Inhibition of renal microsomal protein chain elongation following in vivo cyclosporine A. Biochem Pharmacol 38:4085-4093
52. Ryffel B 1989 Pharmacology of cyclosporine. VI. Cellular activation: Regulation of intracellular events by cyclosporine. Pharmacol Rev 41:407-422
53. Rossaro L, Dowd SR, Ho C, Van Theil DH 1988 19F nuclear magnetic resonance studies of cyclosporine and model unilamellar vesicles: Where does the drug sit within the membrane? Transplant Proc 20:41-45
54. Kan KW, Ungar F 1973 Characterization of an adrenal activator for cholesterol side chain cleavage. J Biol Chem 248:2868-2875
55. Teicher BA, Shikita M, Talalay P 1978 Effects of adrenal steroid activator protein on the conversion of various 20 and 22 hydroxy-cholesterols to pregnenolone by adrenal mitochondrial enzymes. Biochem Biophys Res Commun 83:1436-1441
56. Moyle WR, Jungas RL, Greep RO 1973 Metabolism of free and esterified cholesterol by Leydig cell tumor mitochondria. Biochem J 134:415-424
57. Maines MD 1984 Characterization of heme oxygenase in Leydig and Sertoli cells of the rat testes. Biochem Pharmacol 33:1493-1502
58. Kramer RE, Greiner JW, Rumbaugh RC, Sweeney TD, Colby HD 1979 Requirement of the pituitary gland for gonadal hormone effects on hepatic drug metabolism. J Pharmacol Exp Ther 208:19-23
59. Moore MR 1990 Historical introduction to porphyrins and porphyries. In: Dailey HA (ed) Biosynthesis of Heme and Chlorophylls. McGraw-Hill, New York, pp 1-54