Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia

The Journal of Pediatrics

Volumn 119, Issue 6, 1991, Pages 985-989

  Evans, William E ^a,b   Horner, Michelle ^a,b   Chu, Ya Qin ^a,b   Kalwinsky, David ^a,b   Roberts, W Mark ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 THIOGUANINE NUCLEOTIDE; CYTARABINE; MERCAPTOPURINE; METHOTREXATE; TENIPOSIDE; THIOPURINE METHYLTRANSFERASE; UNCLASSIFIED DRUG;

ACUTE LYMPHOCYTIC LEUKEMIA; ARTICLE; BLOOD TOXICITY; CASE REPORT; DISEASE ASSOCIATION; DRUG DOSE; DRUG METABOLISM; DRUG TOXICITY; ENZYME DEFICIENCY; ERYTHROCYTE LEVEL; FEMALE; HEREDITY; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; PRESCHOOL CHILD; PRIORITY JOURNAL;

6-MERCAPTOPURINE; CASE REPORT; CHILD; ERYTHROCYTES; FEMALE; HUMAN; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; METABOLISM, INBORN ERRORS; METHYLTRANSFERASES; PURINE NUCLEOTIDES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; THIOGUANINE;

EID: 0025837127     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-3476(05)83063-X     Document Type: Article

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