Comparison of an Antiinflammatory Dose of Ibuprofen, an Analgesic Dose of Ibuprofen, and Acetaminophen in the Treatment of Patients with Osteoarthritis of the Knee

New England Journal of Medicine

Volumn 325, Issue 2, 1991, Pages 87-91

  Bradley, John D ^a   Brandt, Kenneth D ^a   Katz, Barry P ^a   Kalasinski, Lorrie A ^a   Ryan, Sarah I ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IBUPROFEN; PARACETAMOL;

ADULT; AGED; ANALGESIA; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DISABILITY; DOUBLE BLIND PROCEDURE; DRUG DOSE; DRUG EFFECT; DRUG EFFICACY; FEMALE; HUMAN; KNEE; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; OSTEOARTHRITIS; PAIN; PRIORITY JOURNAL; RANDOMIZATION;

ACETAMINOPHEN; CHRONIC DISEASE; COMPARATIVE STUDY; DOUBLE-BLIND METHOD; FEMALE; HUMAN; IBUPROFEN; KNEE JOINT; LOCOMOTION; MALE; MIDDLE AGE; OSTEOARTHRITIS; PAIN; QUESTIONNAIRES; RANGE OF MOTION, ARTICULAR; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0025835964     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199107113250203     Document Type: Article

References (38)

1. Lawrence JS, Bremner JM. Bier F. Osteo-arthrosis: prevalence in the population and relationship between symptoms and x-ray changes. Ann Rheum Dis 1966; 25: 1–24
2. National Center for Health Statistics. Prevalence of osteoarthritis in adults by age, sex, race, and geographic area: United States-1960–1962. Vital and health statistics. Series 11. No. 15. Washington, D.C.: Government Printing Office, 1966
3. Howell DS, Sapolsky AI, Pita JC, Woessner JF. The pathogenesis of osteoarthritis. Semin Arthritis Rheum 1976; 5: 365–83
4. Myers SL, Brandt KD, Ehlich JW, et al. Synovial inflammation in patients with early osteoarthritis of the knee. J Rheumatol 1990; 17: 1662–9
5. Gordon GV, Villanueva T, Schumacher HR. Gohel V. Autopsy study correlating degree of osteoarthritis, synovitis and evidence of articular calcification. J Rheumatol 1984; 11: 681–6
6. Bullough P. Synovial and osseous inflammation in osteoarthritis. Semin Arthritis Rheum 1981; 11: Suppl 1: 146
7. Altman RD, Hochberg MC. Degenerative joint disease. Clin Rheum Dis 1983; 9: 681–93
8. Miller MR, Kasahara M. Observations on the innervation of human long bones. Anat Rec 1963; 145: 13–7
9. Lempberg RK, Arnoldi CC. The significance of intraosseous pressure in normal and diseased states with special reference to intraosseous engorgement-pain syndrome. Clin Orthop 1978; 136: 143–56
10. Bollet AJ. Analgesic and anti-inflammatory drugs in the therapy of osteoarthritis. Semin Arthritis Rheum 1981; 11: Suppl 1: 130–2
11. Coles LS, Fries JF, Kraines RG, Roth SH. From experiment to experience: side effects of nonsteroidal anti-inflammatory drugs. Am J Med 1983; 74: 820–8
12. Lanza FL. Endoscopic studies of gastric and duodenal injury after use of ibuprofen, aspirin and other nonsteroidal anti-inflammatory drugs. Am J Med 1984; 77: Suppl 1A: 19–24
13. Griffin MR, Piper JM, Daugherty JR, Snowden M, Ray WA. Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Ann Intern Med 1991; 114: 257–63
14. Soll AH, Weinstein WM, Kurata J, McCarthy D. Nonsteroidal anti-inflammatory drugs and peptic ulcer disease. Ann Intern Med 1991; 114: 307–19
15. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis 1957; 16: 494–501
16. Fries JF, Spitz PW, Young DY. The dimensions of health outcomes: the Health Assessment Questionnaire, disability and pain scales. J Rheumatol 1982; 9: 789–93
17. Baum C, Kennedy DL, Forbes MB. Utilization of nonsteroidal antiinflammatory drugs. Arthritis Rheum 1985; 28: 686–92
18. Anderson JJ, Firschein HE, Meenan RF. Sensitivity of a health status measure to short-term clinical changes in arthritis. Arthritis Rheum 1989; 32: 844–50
19. Tyson VCH, Glynne A. A comparative study of benoxaprofen and ibuprofen in osteoarthritis in general practice. J Rheumatol Suppl 1980; 6: 132–8
20. Levinson DJ, Rubinstein HM. Double-blind comparison of fenoprofen calcium and ibuprofen in osteoarthritis of large joints. Curr Ther Res 1983; 34: 280–4
21. Huskisson EC, Hart FD, Shenfield GM, Taylor RT. Ibuprofen: a review. Practitioner 1971; 207: 639–43
22. Gall EP, Caperton EM, McComb JE, et al. Clinical comparison of ibuprofen, fenoprofen calcium, naproxen and tolmetin sodium in rheumatoid arthritis. J Rheumatol 1982; 9: 402–7
23. Breshnihan B, Hughes G, Essigman WK. Diflunisal in the treatment of osteoarthrosis: a double-blind study comparing diflunisal with ibuprofen. Curr Med Res Opin 1978; 5: 556–61
24. Moxley TE, Royer GL, Hearron MS, Donovan JF, Levi L. Ibuprofen versus buffered phenylbutazone in the treatment of osteoarthritis: double-blind trial. J Am Geriatr Soc 1975; 23: 343–9
25. de Blécourt JJ. A comparative study of ibuprofen (Brufen') and indomethacin in uncomplicated arthrosis. Curr Med Res Opin 1975; 3: 477–80
26. Cimmino MA, Cutolo M, Samanta E, Accardo S. Short-term treatment of osteoarthritis: a comparison of sodium meclofenamate and ibuprofen. J Int Med Res 1982; 10: 46–52
27. Amadio P Jr, Cummings DM. Evaluation of acetaminophen in the management of osteoarthritis of the knee. Curr Ther Res 1983; 34: 59–66
28. Doyle DV, Dieppe PA, Scott J, Huskisson EC. An articular index for the assessment of osteoarthritis. Ann Rheum Dis 1981; 40: 75–8
29. Parr G, Darekar B, Fletcher A, Bulpitt CJ. Joint pain and quality of life: results of a randomized trial. Br J Clin Pharmacol 1989; 27: 235–42
30. Stamp J, Rhind V, Haslock I. A comparison of nefopam and flurbiprofen in the treatment of osteoarthritis. Br J Clin Pract 1989; 43: 24–6
31. Dieppe P, Cushnaghan J, Jasani K, McCrae F, Watt I. A two-year placebo-controlled trial of a non-steroidal anti-inflammatory (NSAID) in knee osteoarthritis (OA). Br J Rheumatol 1990; 29: Suppl 2: 129
32. Sandler DP, Smith JC, Weinberg CR, et al. Analgesic use and chronic renal disease. N Engl J Med 1989; 320: 1238–43
33. Amadio P Jr. Peripherally acting analgesics. Am J Med 1984; 77: Suppl 3A: 17–25
34. Doyle DV, Lanham JG. Routine drug treatment of osteoarthritis. Clin Rheumatol Dis 1984; 10: 277–91
35. Calin A. Pain and inflammation. Am J Med 1984; 77: Suppl 3A: 9–15
36. Clive DM, Stoff JS. Renal syndromes associated with nonsteroidal anti-inflammatory drugs. N Engl J Med 1984; 310: 563–72
37. Crain DC. Interphalangeal osteoarthritis: characterized by painful inflammatory episodes resulting in deformity of the proximal and distal articulations. JAMA 1961; 175: 1049–53
38. Peyron JG. Osteoarthritis: the epidemiologic viewpoint. Clin Orthop 1986; 213: 13–9