Cytotoxic T-Lymphocytes Derived from Patients with Breast Adenocarcinoma Recognize an Epifope Present on the Protein Core of a Mucin Molecule Preferentially Expressed by Malignant Cells

Cancer Research

Volumn 51, Issue 11, 1991, Pages 2908-2916

  Finn, Olivera J ^a,g   Bast, Robert C ^b   Bendt, Katharine M ^a  

^a Department of Microbiology anil Immunology ^*  (United Kingdom)

^b The Department of Medicine ^*  (United Kingdom)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^e UNIVERSITY OF MELBOURNE   (Australia)

^f NATIONAL CANCER INSTITUTE   (United States)

^g UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MUCIN; PROTEIN;

ARTICLE; BREAST CARCINOMA; CANCER CELL; CELL DEATH; CYTOTOXIC T LYMPHOCYTE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE; PRIORITY JOURNAL;

ADENOCARCINOMA; AMINO ACID SEQUENCE; ANTIBODIES, NEOPLASM; ANTIGENS, NEOPLASM; BREAST NEOPLASMS; EPITOPES; HLA ANTIGENS; HUMAN; LYMPHATIC METASTASIS; MOLECULAR SEQUENCE DATA; MUCINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES, CYTOTOXIC; TUMOR CELLS, CULTURED;

EID: 0025834851     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Mukherji, B., and MacAlister, T. J. Clonal analysis of cytotoxic T cell response against human melanomas. J. Exp. Med., 158: 240-245, 1983.
2. Knuth, A., Wolfel, T., Klehman, E., Boon, T., and Meyer zum Buschenfelde, K. H. Cytolytic T-cell clones against an autologous human melanoma: Specificity study and definition of three antigens by immunoselection. Proc. Natl. Acad. Sci. USA, 86:2804-2808, 1989.
3. DeVries, J. E., and Spits, H. Cloned human cytotoxic lymphocyte lines reactive with autologous melanoma cells. J. Immunol., 132:510-519, 1984.
4. Anichini, A., Fossati, G., and Parmiani, G. Clonal analysis of cytotoxic T-lymphocyte response to autologous human metastatic melanoma. Int. J. Cancer, 35:683-689, 1985.
5. Slovin, S. F., Lackman, R. D., Ferrone, S., Kiely, P. E., and Mastrangelo, M. Cellular immune response to human sarcomas: Cytotoxic T cell clones reactive with autologous sarcomas. I. Development, phenotype and specificity. J. Immunol., 132: 3042-3048, 1986.
6. Hershey, P., MacDonald, M., Schibeci, S., and Bums, C. Clonal analysis of cytotoxic T lymphocytes (CTL) against autologous melanoma. Cancer Immunol. Immunother., 22: 15-23, 1986.
7. Sato, T., Sato, N., Takahashi, S., Koshiba, H., and Kikuchi, A. Specific cytotoxicity of a long term cultured T-cell clone on human autologous mammary cancer cells. Cancer Res., 46:4384-4389,1986.
8. Barnd, D., Kerr, L., Metzgar, R., and Finn, O. Human tumor-specific T cell lines generated from tumor draining lymph node infiltrate. Transplant. Proc., 20:339-341, 1988.
9. Cozzolino, F., Torcia, M., Carossino, A., Giordani, R., Selli, C., Talini, G., Reali, E., Novelli, A., Pistoia, V., and Ferrarini, M. Characterization of cells from invaded lymph nodes in patients with solid tumors. J. Exp. Med., 166: 303-318, 1987.
10. Mukherji, B., Guha, A., Chakrabarty, N., Sivandham, M., Naftjed, A., Spom, J., and Ergin, M. Clonal analsis of cytotoxic and regulatory T cell responses against human melanoma. J. Exp. Med., 169: 1961-1967, 1989.
11. Muul, L. M., Spiess, P. J., Director, E. P., and Rosenberg, S. A. Identification of specific cytolytic immune responses against autologous tumor in humans bearing malignant melanoma. J. Immunol., 738:989-995,1987.
12. Topalian, S. L., Solomon, D., and Rosenberg, S. A. Tumor-specific cytolysis by lymphocytes infiltrating human melanomas. J. Immunol., 142: 3714-3725,1989.
13. Whiteside, T. L., Miescher, S., Hulimann, J., Moretta, L., and Von Hiedner, U. Clonal analysis and in situ characterization of lymphocytes infiltrating human breast carcinomas. Cancer Immunol. Immunother., 23: 169-178, 1986.
14. Rosenberg, S. A. Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. N. Engl. J. Med., 319: 1676-1680, 1988.
15. Lotze, M. T., Tomita, S., and Rosenberg, S. A. Human tumor antigens defined by cytotoxic and proliferative T cells. In: R. S. Metzgar and M. S. Mitchell (eds.). Human Tumor Antigens and Specific Tumor Therapy, pp. 167-179. New York: Alan R. Liss, Inc., 1989.
16. Barnd, D. L., Lan, M., Metzgar, R., and Finn, O. J. Specific, MHC-unrestricted recognition of tumor-associated mucins by human cytotoxic T cells. Proc. Natl. Acad. Sci. USA, 86: 7159-7163, 1989.
17. Burchell, J., Gendler, S., Taylor-Papadimitriou, J., Girling, A., Lewis, A., Millis, R., and Lamport, D. Development and characterization of breast cancer reactive monoclonal antibodies directed to the protein core of the human milk mucin. Cancer Res., 47:5476-5482, 1987.
18. Roussel, P., Lamblin, G., Lhermitte, M., Houdret, N., Lafitte, J-J., Perini, J-M., Klein, A., and Scharfman, A. The complexity of mucins. Biochimie, 70: 1471-1482, 1988.
19. Gendler, S., Taylor-Papadimitriou, J., Duhlig, T., Rothbard, J., and Burchell, J. A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats. J. Biol. Chem., 263: 12820-12823, 1988.
20. Lan, M. S., Batra, S. K., Qi, W-N., Metzgar, R. S., and Hollingsworth, M. A. Cloning and sequencing of a human pancreatic tumor mucin cDNA. Cancer Res., 50:2997-3001,1990.
21. Finn, O. J., Barnd, D. L., Kerr, L., Miceli, M. C., and Metzgar, R. Specific recognition of human tumor antigens by non-MHC-restricted CTL. In: R. Metzgar and M. Mitchell (eds.). Human Tumor Antigens and Specific Tumor Therapy, pp. 157-166. New York: Alan R. Liss, Inc., 1989.
22. Borst, J., van de Griend, R., van Oostveen, J., Ang, S., Melief, C., Seidman, J., and Bolhuis, R. A T-cell receptor 7/CD3 complex found on cloned functional lymphocytes. Nature (Lond.), 325:683-688,1987.
23. Brenner, M., McLean, J., Schleft, H., Riberdy, J., Ang, S., Seidman, J., Devlin, P., and Krangel, M. Two forms of the T-cell receptor y protein found on peripheral blood cytotoxic T lymphocytes. Nature (Lond.), 325:689-694, 1987.
24. Alcaron, B., DeVries, J., Pettey, C., Boylston, A., Yssel, H., Terhorst, C., and Spits, H. The T-cell receptor y chain-CD3 complex: Implication in the cytotoxic activity of a CD3+ CD4” CD8” human natural killer clone. Proc. Natl. Acad. Sci. USA, 84:3861-3865, 1987.
25. Bast, R., Feeney, M., Lazarus, H., Nadler, L., Colvin, R., and Knapp, R. Reactivity of a monoclonal antibody with human ovarian carcinomas. J. Clin. Invest., 68: 1331-1337, 1981.
26. Stampfer, M. R. Isolation and growth of human mammary epithelial cells. J. Tissue Culture Methods, 9: 107-115,1985.
27. King, P., Tjandra, J., Reynolds, K., McLaughlin, P., Purcell, D., and McKenzie, I. Reactivity of anti-human milk fat globule antibodies with synthetic peptides. J. Immunol., 142: 3503-3509, 1989.
28. Dillman, K. O., Shawler, D. C., Sobal, R., Collins, H., Beauregard, S. D., Wormsley, S. B., and Royston, I. Murine monoclonal antibody therapy in two patients with chronic lymphocytic leukemia. Blood, 59: 1036-1045, 1982.
29. Altman, D. M., Lider, O., Douek, D. C., and Cohen, I. R. Activation of specific T cell lines by the antigens avidin and myelin basic protein in the absence of antigen-presenting cells. Eur. J. Immunol., 77: 1635-1640,1987.
30. Sherman, L. A., and Lara, A. M. Unrestricted recognition of a nonpeptide antigen by CD8+ cytolytic T lymphocytes. J. Immunol., 143: 3444-3447, 1989.
31. Mauer, S., Schlossman, S., and Reinherz, E. Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions. Proc. Natl. Acad. Sci. USA, 79:4395-4399, 1982.
32. Nakamura, M., Ross, D., Briner, T., and Gefter, M. Cytolytic activity of antigen-specific T cells with helper phenotype. J. Immunol, 136: 44-47, 1986.
33. Margalit, H., Spouge, J., Comette, J., Cease, K., Delisi, C., and Berzofsky, J. Prediction of immunodominant T cell antigenic sites from the primary sequence. J. Immunol., 138:2213-2229, 1987.
34. Xing, P. X., Tjandra, J. J., Stacker, S. A., Teh, J. G., Thompson, C. H., McLaughlin, P. J., and McKenzie, I. F. C. Monoclonal antibodies reactive with mucin expressed in breast cancer. Immunol. Cell Biol., 67: 183-195, 1989.
35. Xing, P. X., Reynolds, K., Tjandra, J. J., Tang, X. L., Purcell, D. F. J., and McKenzie, I. F. C. Synthetic peptides reactive with anti-human milk fat globule membrane monoclonal antibodies. Cancer Res., 50: 89-96, 1990.
36. Bushkin, Y., Demaria, S., Le, J., and Schwab, R. Physical association between the CD8 and HLA class I molecules on the surface of activated human T lymphocytes. Proc. Natl. Acad. Sci. USA, 85: 3985-3989, 1988.
37. Girling, A., Bartkova, J., Burchell, J., Gendler, S., Gillett, C., and Taylor-Papadimitriou, J. A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM-3 is selectively exposed in a range of primary carcinomas. Int. J. Cancer, 43: 1072-1076, 1989.
38. Rosenberg, S., Speiss, P., and Lafreniere, R. A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes. Science (Washington DC), 233: 1318-1321, 1986.
39. Papsidero, L., and Johnson, E. Physicochemical purification and immunological characteristics of ductal carcinoma antigen. Int. J. Cancer, 37: 697-703, 1986.
40. Wolf, M., Koemer, U., Klumpp, B., and Schumacher, K. Characterization of Thomsen-Friedenreich antibody subpopulations from normal human serum. Tumor Biol., 8: 264-272, 1987.
41. Kjeldsen, T., Clausen, H., Hirohashi, S., Ogawa, T., and lijima, H. Preparation and characterization of monoclonal antibodies directed to the tumor-associated O-linked sialosyl-2-+ alpha-A-acetylgalactosaminyl (sialosyl-Tn) epitope. Cancer Res., 48: 2214-2220, 1988.
42. Lan, M., Khorrami, A., Kaufman, B., and Metzgar, R. Molecular characterization of a mucin-type antigen associated with human pancreatic cancer. J. Biol. Chem., 262: 12863-12870, 1987.
43. Gendler, S., Taylor-Papadimitriou, J., Burchell, J., and Duhig, T. A polymorphic epithelial mucin expressed by breast and other carcinomas: Immunological and molecular studies. In: R. Metzar and M. Mitchell (eds.). Human Tumor Antigens and Specific Tumor Therapy, pp. 11-23. New York: Alan R. Liss, Inc., 1989.
44. Griffiths, A., Burchell, J., Gendler, S., Lewis, A., Blight, K., Tilly, R., and Taylor-Papadimitriou, J. Immunological analysis of mucin molecules expressed by normal and malignant mammary epithelial cells. Int. J. Cancer, 141:319-327, 1987.
45. Siliciano, R., Hemesath, T., Pratt, J., Dintzis, R., Dintzis, H., Acuto, O., Shin, H., and Reinherz, E. Direct evidence for the existence of nominal antigen binding sites of T cell surface Ti a-0 heterodimers of MHC-restricted T cell clones. Cell, 47: 161-171, 1986.
46. Rao, A., Ko, W. W-P., Faas, S. J., and Cantor, H. Binding of antigen in the absence of histocompatibility proteins by arsonate-reactive T-cell clones. Cell, 36: 879-888, 1984.
47. Rao, A., Faas, S. J., and Cantor, H. Activation specificity of arsonate-reactive T cell clones: Structural requirements for hapten recognition and comparision with monoclonal antibodies. J. Exp. Med., 159:479-494, 1984.
48. Gum, J., Byrd, J., Hicks, J., Toribara, N., Lamport, D., and Kim, Y. Molecular cloning of human intestinal mucin cDNAs: Sequence analysis and evidence for genetic polymorphism. J. Biol. Chem., 264:6480-6487, 1989.
49. Hand, P., Nuti, M., Colcher, D., and Schlom, J. Definition of antigenic heterogeneity and modulation among human mammary carcinoma cell populations using monoclonal antibodies to tumor-associated antigens. Cancer Res., 43: 728-735, 1983.
50. Burchell, J., Taylor-Papadimitriou, J., Boshell, M., Gendler, S., and Duhig, T. A short sequence, within the amino acid repeat of a cancer associated mucin, contains immunodominant epitopes. Int. J. Cancer, 44: 691-696, 1989.
51. Jerome, K. R., Barnd, D. L., Boyer, C. M., Taylor-Papadimitriou, J., McKenzie, I. F. C., Bast, R. C., Jr., and Finn, O. J. Adenocarcinoma reactive cytotoxic T lymphocytes recognize an epitope present on the protein core of epithelial mucin molecules. In: M. Lotze and O. Finn (eds.). Cellular Immunity and the Immunotherapy of Cancer, pp. 321-328. New York: Wiley-Liss, Inc., 1990.
52. Hanisch, F. G., Uhlenbruck, G., Peter-Katalinic, J., Egge, H., Dabrowski, J., and Dabrowski, U. Structures of neutral O-linked polylactosaminoglycans on human skim milk mucins. J. Biol. Chem., 264: 872-883, 1989.
53. Hull, S. R., Bright, A., Carraway, K. L., Abe, M., and Kufe, D. Oligosaccharides of the DF3 antigen of the BT-20 human breast carcinoma cell line (Abstract). J. Cell Biochem. Suppl., 123: 130, 1988.
54. Hayes, D., Sekine, H., Ohno, T., Abe, M., Keefe, K., and Kufe, D. Use of a murine monoclonal antibody for detection of circulating plasma DF3 antigen levels in breast cancer patients. J. Clin. Invest, 75: 1671-1678, 1985.