Diversity of penetration of anti‐cancer agents into solid tumours

Cell Proliferation

Volumn 24, Issue 4, 1991, Pages 355-365

  Simpson Herren L ^a   Noker, P E ^a  

^a SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; DOXORUBICIN; DYE; MELPHALAN; MESYLMESYLIC ACID 2 CHLOROETHYL ESTER; METRONIDAZOLE; MISONIDAZOLE; MITOMYCIN C; PHENAZONE; SEMUSTINE; TRIPHENYLMETHANE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST ADENOCARCINOMA; CANCER CHEMOTHERAPY; CLASSIFICATION; CLONOGENESIS; CYTOTOXICITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG MEGADOSE; DRUG PENETRATION; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; PERFUSION; SOLID TUMOR; TUMOR CELL; VASCULARIZATION;

ADENOCARCINOMA; ALKYLATING AGENTS; ANIMAL; ANTINEOPLASTIC AGENTS; ANTIPYRINE; BIOLOGICAL TRANSPORT; BREAST NEOPLASMS; CARBON RADIOISOTOPES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMAN; KINETICS; MELPHALAN; MICE; MICE, INBRED C3H; NEOPLASM TRANSPLANTATION; SUPPORT, U.S. GOV'T, P.H.S.; TRANSPLANTATION, HETEROLOGOUS;

EID: 0025832209     PISSN: 09607722     EISSN: 13652184     Source Type: Journal    
DOI: 10.1111/j.1365-2184.1991.tb01164.x     Document Type: Article

References (38)

1. Quantification of tumour blood flow and blood flow distribution
2. Reversed‐phase high‐performance liquid chromatographic determination of mitomycin C in human serum
3. High pressure liquid chromatographic analysis of melphalan in plasma
4. The proportion of hypoxic cells in a human tumour
5. Chemosensitivity testing in V79 spheroids: drug delivery and cellular microenvironment
6. Distribution and activity of antineoplastic drugs in a tumour model
7. Slow penetration of anthracyclines into spheroids and tumours: a therapeutic advantage
8. Antitumor activity of 2‐chloroethy (methylsulfonyl) methanesulfonate (Clomesone, NSC 338947) against selected tumour systems in mice
9. 31P NMR study of the metabolism of murine mammary 16/C adenocarcinoma and its response to chemotherapy, x‐radiation and hyperthermia
10. 3H mouse mammary carcinoma
11. A rapid method for studying tumour blood supply using systematic dyes
12. On the access of blood‐borne dyes to various tumour regions
13. Distribution of Bratton‐Marshall‐positive material in mice following intravenous injections of nitrosoureas
14. Aspects of cytotoxic drug penetration, with particular reference to anthracyclines
15. Modification of the hypoxic fraction of xenografted human colon tumor by differentiation‐inducing agents
16. Intrinsic and extrinsic heterogeneity in the responses of parent and clonal human colon carcinoma xenografts to photon irradiation
17. Hypoxic fractions of solid tumors: experimental techniques, methods of analysis and a survey of existing data
18. Role of the host in the variable chemotherapeutic response of advanced Ridgway osteogenic sarcoma
19. Distribution of nitroimidazoles in mammary adenocarcinoma 16/C tumors
20. A rapid method for studying tumor blood supply using lissamine green
21. Pharmacokinetics of adriamycin and tissue penetration in murine ovarian cancer
22. Tumor‐to‐tumor variability in the hypoxic fractions of experimental rodent tumours
23. 14C]antipyrine
24. Variable response of advanced solid tumors of mice to treatment with anticancer drugs
25. 2‐Haloethylating agents for cancer chemotherapy. 2‐Haloethyl sulfonates
26. 2‐Chloroethyl (methylsulfonyl) methanesulfonate and related (methylsulfonyl) methanesulfonates. Antineoplastic activity in vivo
27. Variability of tumor response to chemotherapy I. Contribution of host heterogeneity
28. Variability of tumor response to chemotherapy 11. Contribution of tumor heterogeneity
29. Effects of the initial chemotherapy on subsequent therapy
30. Distribution of adriamycin in mice bearing mammary adenocarcinoma 16/C
31. Cytotoxicity of adriamycin on aerobic and hypoxic Chinese hamster V79 cells in vitro
32. Resistance to adriamycin in multicellular spheroids
33. Response of aerobic and hypoxic cells in a solid tumor to adriamycin and cyclophosphamide and interaction of the drugs with radiation
34. Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells
35. Assay of doxorubicin and 4′‐epidoxorubicin by reversed‐phase ion‐pair chromatography
36. The relationship between regional variations in blood flow and histology in a transplanted rat fibrosarcoma
37. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review
38. Estimation of the hypoxic cell‐sensitizer misonidazole and its O‐demethylated metabolite in biological materials by reversed‐phase high‐performance liquid chromatography