Antiretroviral activities of anthraquinones and their inhibitory effects on reverse transcriptase

Antiviral Research

Volumn 15, Issue 3, 1991, Pages 205-216

  Higuchi, Hirotaka ^a   Mori, Kazuya ^a   Kato, Akihisa ^b   Ohkuma, Tetsuo ^a   Endo, Tohru ^a   Kaji, Hideko ^b   Kaji, Akira ^c  

^a TSUMURA AND CO   (Japan)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Alizarin complexone; Retrovirus; Reverse transcriptase

Indexed keywords

2',3' DIDEOXYTHYMIDINE TRIPHOSPHATE; ALIZARIN; ALIZARIN COMPLEXONE; ALIZARIN RED S; ANTHRAQUINONE DERIVATIVE; FOSCARNET; PURPURIN; QUINALIZARIN; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; ROUS SARCOMA ONCOVIRUS; VIRUS INFECTION;

ANIMAL; ANTHRAQUINONES; ANTIVIRAL AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE, TRANSFORMED; CELLS, CULTURED; CHICKENS; CYTOPATHOGENIC EFFECT, VIRAL; HIV-1; HUMAN; KINETICS; LEUKOSIS VIRUS, AVIAN; PLAQUE ASSAY; RETROVIRIDAE; REVERSE TRANSCRIPTASE INHIBITORS; SARCOMA VIRUSES, AVIAN; SARCOMA, AVIAN; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

ANIMALIA; GALLUS GALLUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; ONCOVIRINAE; RICE STRIPE VIRUS; ROUS SARCOMA VIRUS; ROUS-ASSOCIATED VIRUS; UNIDENTIFIED RETROVIRUS;

EID: 0025829325     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-3542(91)90067-2     Document Type: Article

References (34)

1. Comparative inhibitory effects of suramin and other selected compounds on the infectivity and replication of human T-cell lymphotropic virus (HTLV-III)/lymphadenopathy-associated virus (LAV)
2. Submicro-methods for the analysis of organic compounds Part X determination of fluorine
3. Inhibition of HIV reverse transcriptase by 2′,3′-dideoxynucleoside triphosphates
4. Human immunodeficiency virus reverse transcriptase
5. Effect of streptonigrin (NSC-45383) and analogs on oncornavirus replication and DNA polymerase activity
6. 3′-Azido-3′-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase
7. Inhibition of avian myeloblastosis virus reverse transcriptase and its associated activities by daunomycin and adriamycin
8. Size, score and speed of development of tumors in chickens in response to subcutaneous inoculations with Rous sarcoma virus
9. Inhibition of reverse transcriptase by limocrocin
10. 3′-Substituted 2′,3′-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents
11. Expression of soluble, enzymatically active, human immuno-deficiency virus reverse transcriptase in Escherichia coli and analysis of mutants
12. Role of single-electron reduction potential in inhibition of reverse transcriptase by streptonigrin and sakyomycin A
13. Screening for inhibitors of avian myeloblastosis virus reverse transcriptase and effect on the replication of AIDS-virus
14. Inhibitory effect of tannins on reverse transcriptase from RNA tumor virus
15. HIV with reduced sensitivity to Zidovudine (AZT) isolated during prolonged therapy
16. Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin
17. Chelating reactions of 12-dihydroxyanthraquinon-3-ylmethylamine-NN-diacetic acid with metal cations in aqueous media
18. Specific inhibition of nuclear RNA polymerase II by α-amanitin
19. Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin
20. Type C virus-producing cell lines derived from adult T cell leukemia
21. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
22. Biological properties of streptonigrin derivatives II: inhibition of reverse transcriptase activity
23. Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds
24. Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives
25. Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS
26. The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex
27. Enzyme inhibition VI: inhibition of reverse transcriptase activity by protoberberine alkaloids and structure-activity relationships
28. Comparison of inhibition of reverse transcriptase and antileukemic activities exhibited by protoberberine and benzophenanthridine alkaloids and structure-activity relationships
29. Monoclonal antibody and enzymatic profiles of human malignant T-lymphoid cells and derived cell lines
30. Focus assay of Rous sarcoma virus
31. PPi Analogs as inhibitors of human T-lymphotropic virus type III reverse transcriptase
32. Comparison of the effect of carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases
33. Inhibition of HIV-1 RNA-dependent DNA polymerase and cellular DNA polymerases α,β and γ by phosphonoformic acid and other drugs
34. Quantitative structure-activity correlations of rifamycins as inhibitors of viral RNA-directed DNA polymerase and mammalian α and β DNA polymerases