A Preliminary, Open Study of the Combination of Fluoxetine and Desipramine for Rapid Treatment of Major Depression

Archives of General Psychiatry

Volumn 48, Issue 4, 1991, Pages 303-307

  Nelson, J Craig ^a   Mazure, Carolyn M ^a   Bowers, Malcolm B ^a   Jatlow, Peter I ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DESIPRAMINE; FLUOXETINE;

ADULT; CLINICAL ARTICLE; CONFERENCE PAPER; DEPRESSION; DRUG COMBINATION; FEMALE; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ADULT; AGED; COMPARATIVE STUDY; DEPRESSIVE DISORDER; DESIPRAMINE; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; FLUOXETINE; HOSPITALIZATION; HUMAN; MALE; MIDDLE AGE; PSYCHIATRIC STATUS RATING SCALES; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0025829243     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archpsyc.1991.01810280019002     Document Type: Article

References (36)

1. Sulser F, Vetulani J, Mobley PL. Mode of action of antidepressant drugs. Biochem Pharmacol. 1978;27:257-261.
2. Banerjee SP, Kung LS, Riggi SJ, Chanda SK. Development of β-adrenergic receptor subsensitivity by antidepressants. Nature. 1977;268:455-456.
3. Vetulani J, Stawarz RJ, Dingell JV, Sulser F. A possible common mechanism of action of antidepressant treatments. Naunyn-Schmiedeb. Arch Pharmacol. 1976;293:109-114.
4. Shopsin B, Gershon S, Goldstein M, Freidman F, Wilk S. Use of synthesis inhibitors in defining a role for biogenic amines during imipramine treatment in depressed patients. Psychopharmacol Commun. 1975;1:239-249.
5. Brunello N, Baraccia ML, Chuang D-M, Costa E. Down-regulation of β-adrenergic receptors following repeated injections of desmethylimipramine: permissive role of serotonergic axons. Neuropharmacology. 1982;21:1145-1149.
6. Stockmeier CA, Martino AM, Kellar KJ. A strong influence of serotonergic axons on β-adrenergic receptors in rat brain. Science. 1985;230:323-325.
7. Dumbrille-Ross A, Tang SW. Noradrenergic and serotonergic input necessary for imipramine-induced changes in beta but not S2 receptor densities. Psychiatry Res. 1983;9:207-215.
8. Baron BM, Ogden AM, Siegel BW, Stegeman J, Ursillo RC, Dudley MW. Rapid down regulation of B-adrenoceptors by co-administration of desipramine and fluoxetine. Eur J Pharmacol. 1988;154:125-134.
9. Nelson JC, Jatlow P, Quinlan DM, Bowers MB Jr. Desipramine plasma concentrations and antidepressant response. Arch Gen Psychiatry. 1982; 39:1419-1422.
10. Vaughan DA. Interaction of fluoxetine with tricyclic antidepressants. Am J Psychiatry. 1988;145:1478.
11. Bell IR, Cole JO. Fluoxetine induces elevation of desipramine and exacerbation of geriatric nonpsychotic depression. J Clin Psychopharmacol. 1988;8:447-448.
12. Downs JM, Downs AD, Rosenthal TL, Deal N, Akiskal HS. Increased plasma tricyclic antidepressant concentrations in two patients concurrently treated with fluoxetine. J Clin Psychiatry. 1989;50:226-227.
13. Aranow RB, Hudson JI, Pope HG, Grady TA, Laage TA, Bell IR, Cole JO. Elevated antidepressant plasma levels after addition of fluoxetine. Am J Psychiatry. 1989;146:911-913.
14. DeMaso DR, Hunter TA. Combining fluoxetine with desipramine. J Am Acad Child Adolesc Psychiatry. 1990;29:151.
15. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56-62.
16. Nelson JC, Jatlow PI, Mazure C. Rapid desipramine dose adjustment using 24-hour levels. J Clin Psychopharmacol. 1987;7:72-77.
17. Proelss HF, Logman HJ, Miles DG. High performance liquid chromatographic simultaneous determination of commonly used antidepressants. Clin Chem. 1978;24:1948-1953.
18. Bock J, Nelson JC, Gray S, Jatlow P. Desipramine hydroxylation: variability and effect of antipsychotic drugs. Clin Pharmacol Ther. 1983;33:322-328.
19. Mazure C, Nelson JC, Price LH. Reliability and validity of the symptoms of major depressive illness. Arch Gen Psychiatry. 1986;43:451-456.
20. Guy W. ECDEU Assessment Manual. Rockville, Md: National Institute of Mental Health; 1976:218-222.
21. Nelson JC, Mazure CM, Jatlow PI. Does melancholia predict outcome in major depression? J Affect Dis. 1990;18:157-165.
22. Nelson JC, Mazure CM, Jatlow PI. Predictors of tricyclic failure. In: Scientific Proceedings of the American Psychiatric Association, New Research. Washington, DC: American Psychiatric Association; 1989:153.
23. Nelson JC, Mazure C, Jatlow PI. Antidepressant activity of 2-hydroxydesipramine. Clin Pharmacol Ther. 1988;44:283-288.
24. Weilburg JB, Rosenbaum JF, Biederman J, Sachs GS, Pollack MH, Kelly K. Fluoxetine added to non-MAOI antidepressants converts nonresponders to responders: a preliminary report. J Clin Psychiatry. 1989;50:447-449.
25. Paul SM, Crews FT. Rapid desensitization of cerebral cortical betaadrenergic receptors induced by desmethylimipramine and phenoxybenzamine. Eur J Pharmacol. 1980;62:349-350.
26. Johnson RW, Reisine T, Spotnitz S, Wiech N, Ursillo R, Yamamura HI. Effects of desipramine and yohimbine on alpha2- and beta-adrenoreceptor sensitivity. Eur J Pharmacol. 1980;67:123-127.
27. Charney DS, Price LH, Heninger GR. Desipramine-yohimbine combination treatment of refractory depression. Arch Gen Psychiatry. 1986;43:1155-1161.
28. Sulser F. Serotonin-norepinephrine receptor interactions in the brain: implications for the pharmacology and pathophysiology of affective disorders. J Clin Psychiatry. 1987;48(suppl):12-18.
29. Preskorn SH, Beber JH, Faul JC, Hirschfeld RMA. Serious adverse effects of combining fluoxetine and tricyclic antidepressants. Am J Psychiatry. 1990;147:532.
30. Feighner JP, Boyer WF, Tyler DL, Neborsky RJ. Adverse consequences of fluoxetine-MAOI combination therapy. J Clin Psychiatry. 1990;51:222-225.
31. Nelson JC, Jatlow PI, Bock J, Quinlan DM, Bowers MB Jr. Major adverse reactions during desipramine treatment: relationship to drug plasma concentrations, concomitant antipsychotic treatment and patient characteristics. Arch Gen Psychiatry. 1982;39:1055-1061.
32. Nelson JC, Jatlow P, Quinlan DM. Subjective side effects during desipramine treatment. Arch Gen Psychiatry. 1984;41:55-59.
33. Stark P, Hardison CD. A review of multicenter controlled studies of fluoxetine vs imipramine and placebo in outpatients with major depressive disorder. J Clin Psychiatry. 1985;46(pt 2):53-58.
34. Rickels K, Amsterdam JD, Avallone MF. Fluoxetine in major depression: a controlled study. Curr Ther Res. 1986;39:559-563.
35. Perry PJ, Garvey MJ, Kelly MW, Cook BL, Dunner FJ, Winokur G. A comparative trial of fluoxetine vs trazodone in outpatients with major depression. J Clin Psychiatry. 1989;50:290-294.
36. Schweizer E, Rickels K, Amsterdam JD, Fox I, Puzzuoli G, Weise C. What constitutes an adequate antidepressant trial for fluoxetine? J Clin Psychiatry. 1990;51:8-11.