Proteins of synaptic vesicles involved in exocytosis and membrane recycling

Neuron

Volumn 6, Issue 5, 1991, Pages 665-677

  Südhof, Thomas C ^a   Jahn, Reinhard ^b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

SYNAPSIN;

ANIMAL TISSUE; EXOCYTOSIS; NEUROTRANSMITTER RELEASE; NEUROTRANSMITTER UPTAKE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SYNAPSE VESICLE;

EXOCYTOSIS; IN VITRO; MEMBRANE GLYCOPROTEINS; NERVE ENDINGS; NERVE TISSUE PROTEINS; NEUROPEPTIDES; NEUROTRANSMITTERS; SYNAPSINS; SYNAPTIC MEMBRANES; SYNAPTIC VESICLES; SYNAPTOPHYSIN;

EID: 0025828234     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/0896-6273(91)90165-V     Document Type: Article

References (106)

1. Purification and properties cf a new clathrin assembly protein
2. Auxilin, a newly identified clath rin-associated protein in coated vesicles from bovine brain
3. Transmitter release from synapses: does a preassembled fusion pore initiate exocytosis?
4. Regulation of reversible binding of smg p25A, a ras p21-like GTPbinding protein, to synaptic plasma membranes and vesicles by its specific regulatory protein, GDP dissociation inhibitor
5. Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2
6. Synapsin I bundles F-actin it a phosphorylation-dependent manner
7. Characterization of synapsin I fragments produced by cysteine-specific cleavage: a study of their interactions with F-actin
8. Synapsin I is a spectrinbinding protein immunologically related to erythrocyte protein 4.1.
9. Synapsin I is a microtubulebundling protein
10. Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that cc-purifies with brain synaptic vesicles
11. Choline metabolism in the cerebral cortex of guinea pigs
12. Synaptobrevin: an integral membrane protein of 18,000 daltons present in small synaptic vesicles of rat brain
13. P29: a novel tyrosine-phosphorylated membrane protein present in small clear vesicles of neurons and endocrine cells
14. Presynaptic mechanism for long-term potentiation in the hippocampus
15. Time-resolved fluorescence study of the neuronspecific phosphoprotein synapsin I. Evidence for phosphorylation-dependent conformational changes
16. +-ATPase
17. Cycling of actin assembly in synaptosomes and neurotransmitter release
18. Do GTPases direct membrane traffic in secretion?
19. Polymorphism in clathrin light chains from different tissues
20. Identification of a transmembrane glycoprotein specific for secretory vesicles of neural and endocrine cells
21. 2+-dependent recycling of synaptic vesicles at the frog neuromuscular junction
22. Amino acid sequences surrounding the cAMP-dependent and calcium/ calmodulin-dependent phosphorylation sites in rat and bovine synapsin I
23. Pathways to regulated exocytosis in neurons
24. Synapsin I (protein I), a nerve terminal-specific phosphoprotein. II. Its specific association with synaptic vesicles demonstrated by immunocytochemistry in agarose-embedded synaptosomes
25. Two vesicle-associated membrane protein genes are differentially expressed in the rat central nervous system
26. rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles
27. A small GTP-binding protein dissociates from synaptic vesicles during exocytosis
28. Distribution of protein I in mammalian brain as determined by adetergent-based radioimmunoassay
29. The trans Golgi network: sorting at the exit site of the Golgi complex
30. Phosphorylation of synapsin I at a novel site by proline-directed protein kinase
31. All ras proteins are polyisoprenylated but only some are palmitoylated
32. The role of coated vesicles in recycling of synaptic vesicle membrane
33. Evidence for recycling of synaptic vesicle membrane during transmitter release at the frog neuromuscular junction
34. The cytoskeletal architecture of the presynaptic terminal and molecular structure of synapsin 1
35. +-ATPase
36. Purification and characterization of protein IIIb, a mammalian brain phosphoprotein
37. Differential phosphorylation of multiple sites in purified protein I by cyclic AMP-dependent and calcium-dependent protein kinases
38. Synapsin I (protein p, a nerve terminal-specific phosphoprotein. Ill. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation
39. A 38,000-dalton membrane protein (p38) present in synaptic vesicles
40. Adenosine 3′,5′-monophosphate-dependent phosphorylation of a specific protein in synaptic membrane fractions from rat cerebrum
41. Accumulation of biological amines into chromaffin granules: a model for hormone and neurotransmitter transport
42. The multisubunit structure of synaptophysin. Relationship between disulfide bonding and homo-oligomerization
43. Transmembrane topography and evolutionary conservation of synaptophysin
44. Synaptophysin is targeted to similar microvesicles in CHO and PC12 cells
45. rab3A attachment to the synaptic vesicle membrane mediated by a conserved polyisoprenylated carboxy-terminal sequence
46. Two calcium/ calmodulin-dependent protein kinases which are highly concentrated in brain, phosphorylated protein I at distinct sites
47. Synaptoporin, a novel putative channel protein of synaptic vesicles
48. A neuronal protein (NP185) associated with clathrin-coated vesicles. Characterization of NP185 with monoclonal antibodies
49. ts1
50. The organization of cytoplasm at the presynaptic active zone of a central nervous system synapse
51. Synaptophysin: molecular organization and mRNA expression as determined from cloned cDNA
52. Topogenesis and sorting of synaptophysin: synthesis of a synaptic vesicle protein from a gene transfected into nonneuroendocrine cells
53. VAT-1: an abundant membrane protein from Torpedo cholinergic synaptic vesicles
54. Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse
55. Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices
56. +-ATPases
57. Nucleotide and deduced amino acid sequences of a GTP-binding protein familywith molecular weights of 25,000 from bovine brain
58. Identification of synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue
59. Glutamate uptake by brain synaptic vesicles: energy dependence of transport and functional reconstitution in proteoliposomes
60. Amino acid neurotransmission: spotlight on synaptic vesicles
61. Endocytosis of synaptic vesicle membrane at the frog neuromuscular junction
62. Calcium/calmodulin-dependent protein kinase II increases glutamate and noradrenaline release from synaptosomes
63. The family of protein kinase C for signal transduction
64. Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse
65. Protein tyrosine phosphorylation in synaptic vesicles
66. Clathrin, adaptors, and sorting
67. The structure of cytochrome b561, a secretory vesicle-specific electron transport protein
68. Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C
69. Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans
70. Domain structure of synaptotagmin (p65)
71. Structure of the 116 kDa polypeptide of the clathrincoated vesicle/synaptic vesicle proton pump
72. Synapsin I: an actinbundling protein under phosphorylation control
73. A domain of synapsin I involved with actin bundling shares immunologic cross-reactivity with villin
74. The subpopulation of brain coated vesicles that carries synaptic vesicle proteins contains two unique polypeptides
75. The fine structure of freeze-fractured presynaptic membranes
76. Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides
77. Ion channels in synaptic vesicles from Torpedo electric organ
78. Molecular characterization of synaptophysin, a major calcium-binding protein 3f the synaptic vesicle membrane
79. Temperature-induced seizure and frequency-dependent neuromuscular block in a is mutant of Drosophila
80. A ras-like protein is required or a post-Golgi event in yeast secretion
81. Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of IDP from and the subsequent binding of GTP to smg p25A, a as p21-like GTP-binding protein
82. Characterization of synapsin I binding to small synaptic vesicles
83. Translocation of synapsin I in response to depolarization of isolated nerve terminals
84. Identification of a heparan ulfate-containing proteoglycan as a specific core component of c holinergic synaptic vesicles from Torpedo marmorata
85. Neuromuscular transinission
86. Synapsin I: a regulated synaptic vesicle organizing protein
87. Identification and purification of a functional amine transporter from bovine chromaffin granules
88. Vacuolar proton pumps
89. Synaptic vesicles
90. The structure of the human synapsin I gene and protein
91. A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions
92. A s maptic vesicle membrane protein is conserved from mammals to Drosophila
93. + pump strongly resembles the ATP-synthetase of Archaebacteria
94. Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins
95. Synaptophysin binds to physophilin, a putative synaptic plasma membrane protein
96. Identification of synaptophysin as a hexameric channel protein of the synaptic vesicle membrane
97. Exocytosis from large and small dense cored vesicles in noradrenergic nerve terminals
98. The p65 protein is a calmodulin-binding protein present in several types of secretory vesicles
99. VAMP-1: a synaptic vesicle-associated integral membrane protein
100. Mutational analysis of SEC4 suggests a cyclical mechanism for the regulation of vesicular traffic
101. +-ATPase from chromaffin granules
102. Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles
103. Isolation and reconstitution of the chloride transporter of clathrin-coated vesicles
104. The human rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion