Dodecyl N,N-Dimethylamino Acetate and Azone Enhance Drug Penetration Across Human, Snake, and Rabbit Skin

Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists

Volumn 8, Issue 7, 1991, Pages 933-937

  Hirvonen, Jouni ^a   Rytting, J Howard ^b   Paronen, Petteri ^a   Urtti, Arto ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF KANSAS   (United States)

Author keywords

animal models; Azone; dodecyl N,N dimethylamino acetate; penetration enhancer; percutaneous permeability

Indexed keywords

DIMETHYLAMINOACETIC ACID DODECYL ESTER; FLUOROURACIL; INDOMETACIN; LAUROCAPRAM; PROPRANOLOL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG ABSORPTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; NONHUMAN; NORMAL HUMAN; RABBIT; SKIN PENETRATION; SKIN PERMEABILITY; SNAKE;

AGED; ANIMAL; AZEPINES; FLUOROURACIL; GLYCINE; HUMAN; IN VITRO; INDOMETHACIN; PERMEABILITY; PROPRANOLOL; RABBITS; SKIN ABSORPTION; SNAKES; SPECIES SPECIFICITY; SUPPORT, NON-U.S. GOV'T;

EID: 0025827890     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1023/A:1015824100788     Document Type: Article

References (13)

1. A biological brief on percutaneous absorption
2. Mode of action of penetration enhancers in human skin
3. Lipid-protein-partitioning (LPP) theory of skin enhancer activity: Finite dose technique
4. New alkyl N,N-dialkyl-substituted amino acetates as transdermal penetration enhancers
5. Facilitated transport of basic and acidic drugs in solutions through snakeskin by a new enhancer—dodecyl N,N-dimethylamino acetate
6. Cutaneous pharmacokinetics: 10 steps to percutaneous absorption
7. Shed snake skin and hairless mouse skin as model membranes for human skin during permeation studies
8. Transdermal controlled delivery of propranolol from a multilaminate adhesive device
9. Enhanced percutaneous penetration with 1-dodecyl-azacycloheptan-2-one
10. Effect of the absorption enhancer, Azone, on the transport of 5-fluorouracil across hairless rat skin
11. Dose-dependent enhancement effects of Azone on skin permeability
12. Corneal penetration behavior of β-blocking agents. I. Physicochemical factors
13. ω-Hydroxyacid derivatives in the epidermis of several mammalian species