CPT-11 Converting Enzyme from Rat Serum: Purification and Some Properties

Journal of Pharmacobio-Dynamics

Volumn 14, Issue 6, 1991, Pages 341-349

  Tsuji, Tatsuya ^a   Yoshimoto, Tadashi ^a   Tsuru, Daisuke ^a   Kaneda, Norimasa ^b   Kado, Kunio ^b   Yokokura, Teruo ^b  

^a NAGASAKI UNIVERSITY   (Japan)

^b YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

Author keywords

7 ethyl 10 hydroxy camptothecin (SN 38); 7 ethyl 10 4 (l piperidino) l piperidino carbonyloxycamptothecin (CPT 11); acetylcholine; anticancer drug; camptothecin; carboxylesterase; prodrug

Indexed keywords

4 CHLOROMERCURIBENZOIC ACID; 4 NITROPHENYL ACETATE; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; ACETYLCHOLINE; ANTINEOPLASTIC AGENT; BENZYLSULFONYL FLUORIDE; CAMPTOTHECIN DERIVATIVE; CARBOXYLESTERASE; DRUG METABOLIZING ENZYME; DYFLOS; EDETIC ACID; IRINOTECAN; PHYSOSTIGMINE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME BLOOD LEVEL; ENZYME PURIFICATION; ENZYME SPECIFICITY; ISOELECTRIC FOCUSING; MALE; MOLECULAR WEIGHT; NONHUMAN; RAT;

ANIMAL; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CARBOXYLIC ESTER HYDROLASES; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; ISOELECTRIC POINT; KINETICS; MALE; MOLECULAR WEIGHT; PRODRUGS; RATS; RATS, INBRED STRAINS;

EID: 0025827281     PISSN: 0386846X     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb1978.14.341     Document Type: Article

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