Base-induced polymer hydrolysis in poly(β-hydroxybutyrate/β-hydroxyvalerate) matrices

Journal of Controlled Release

Volumn 16, Issue 3, 1991, Pages 341-347

  Yoshioka, Sumie ^a   Kishida, Akio ^a   Izumikawa, Satoshi ^a   Aso, Yukio ^a   Takeda, Yasushi ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Biodegradable polymer; Degradation; Hydrolysis; Molecular weight distribution; Poly( hydroxybutyrate hydroxyvalerate); Release rate

Indexed keywords

CINNARIZINE; CLONIDINE; INDENOLOL; POLY(3 HYDROXYBUTYRIC ACID); POLY(3 HYDROXYVALERIC ACID); POLYMER; THIORIDAZINE; UNCLASSIFIED DRUG;

ARTICLE; BIODEGRADATION; CONTROLLED STUDY; DRUG RELEASE; GEL PERMEATION CHROMATOGRAPHY; HYDROLYSIS; MOLECULAR WEIGHT; PARTITION COEFFICIENT; PRIORITY JOURNAL; TEMPERATURE;

EID: 0025826368     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-3659(91)90011-2     Document Type: Article

References (9)

1. Polymers for biodegradable medical devices. II. Hydroxybutyrate-hydroxyvalerate copolymers: hydrolytic degradation studies
2. Polymers for biodegradable medical devices. IV. Hydroxybutyrate-valerate copolymers as non-disintegrating matrices for controlled-release oral dosage forms
3. On the biodegradation of poly-gb-hydroxybutyrate (PHB) homopolymer and polyβ-hydroxybutyrate-hydroxyvalerate copolymers
4. Mechanism of enhancement of the release rate of aclarubicin from poly-βhydroxybutyric acid microspheres by fatty acid esters
5. Biodegradable microcapsules: Acceleration of polymeric excipient hydrolytic rate by incorporation of a basic medicament
6. The acceleration of degradationcontrolled drug delivery from polyester microspheres
7. Formulation-assisted biodegradable polymer matrices
8. Application of gel permeation chromatograph-low angle laser light scattering system to kinetic study on degradation of bioerodible polymers