ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

Cell

Volumn 65, Issue 4, 1991, Pages 663-675

  Boulton, Teri G ^a   Nye, Steven H ^b   Robbins, David J ^a   Ip, Nancy Y ^b   Radzlejewska, Elizabeth ^b   Morgenbesser, Sharon D ^c   DePinho, Ronald A ^c   Panayotatos, Nikos ^b   Cobb, Melanie H ^a   Yancopoulos, George D ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b REGENERON PHARMACEUTICALS INC   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; NERVE GROWTH FACTOR; PROTEIN SERINE THREONINE KINASE;

ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; EMBRYO; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

AMINO ACID SEQUENCE; ANIMAL; ASTROCYTES; BASE SEQUENCE; CELL LINE; CELLS, CULTURED; CLONING, MOLECULAR; COMPARATIVE STUDY; ENZYME ACTIVATION; HIPPOCAMPUS; HUMAN; INSULIN; MOLECULAR SEQUENCE DATA; NERVE GROWTH FACTORS; ORGAN SPECIFICITY; P42 MAP KINASE; PHOSPHORYLATION; PROTEIN KINASES; PSEUDOGENES; RATS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, NUCLEIC ACID; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TERATOMA; TYROSINE;

EID: 0025823448     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(91)90098-J     Document Type: Article

References (66)

1. Evidence for epidermal growth factor-stimulated protein kinase cascade in 3T3 cells
2. Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells
3. Multiple components in an EGF-stimulated protein kinase cascade
4. Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
5. Protein phosphatase 2A inactivates the mitogen-stimulated S6 kinase from Swiss mouse 3T3 cells
6. Insulin activates the Raf-1 protein kinase
7. Protein-serine kinase from rat epididymal adipose tissue which phosphorylates and activates acetyl-CoA carboxylase
8. Preparation of DNA and RNA
9. Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies
10. Evidence for insulin-dependent activation of S6 and microtubule-associated protein-2 kinases via a human insulin receptor/v-ros hybrid
11. An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control
12. Purification and properties of ERK1, an insulin-stimulated MAP2 protein kinase
13. src inactivate tyrosine protein kinase activity
14. Activation of multiple protein kinases during the burst in protein phosphorylation that precedes the first meiotic cell division in Xenopus oocytes
15. Changes in protein phosphorylation in Rous sarcoma virus transformed chicken embryo cells
16. Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins
17. Detection and quantification of phosphotyrosine in proteins
18. Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells
19. A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae
20. The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle
21. Inhibition of MAP2 expression affects both morphological and cell division phenotypes of neuronal differentiation
22. Protein serine/threonine kinases
23. +/CDC28-related kinase required for the transition from mitosis into conjugation
24. A 42-kD tyrosine kinase substrate linked to chromaffin cell secretion exhibits an associated MAP kinase activity and is highly related to a 42-kD mitogen-stimulated protein in fibroblasts
25. Thrombin stimulates the activities of multiple previously unidentified protein kinases in platelets
26. Identification of a 42-kilodaiton phosphotyrosyl protein as a serine(threonine) protein kinase by renaturation
27. cdc2 and a MAP kinase homolog in Xenopus oocytes and eggs
28. Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions
29. Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor
30. Evidence for communication between nerve growth factor and protein tyrosine phosphorylation
31. An insulin-stimulated ribosomal protein S6 kinase from rabbit liver
32. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains
33. Effects of the tumor promoter okadaic acid on intracellular protein phosphorylation and metabolism
34. Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes
35. 2+-inhibitable protein kinase that phosphorylates microtubule-associated protein 2 in vitro by growth factors, phorbol esters, and serum in quiescent cultured human fibroblasts
36. Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF
37. Insulin activates the kinase activity of the Raf-1 proto-oncogene by increasing its serine phosphorylation
38. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs
39. Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2
40. Nerve growth factor induces protein-tyrosine phosphorylation
41. Comparison of two different hybridization systems in Northern transfer analysis
42. Neurotrophin-3: a neurotrophic factor related to NGF and BDNF
43. NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression
44. Identification of phosphotyrosine-containing proteins in untransformed and Rous sarcoma virus-transformed chicken embryo fibroblasts
45. Changes in the synthesis and phosphorylation of cellular proteins in chick fibroblasts transformed by two avian sarcoma viruses
46. Control of muscle and neuronal differentiation in a cultured embryonal carcinoma cell line
47. Molecular investigations on the high affinity nerve growth factor receptor
48. Tyrosine kinase activity coupled to the high affinity nerve growth factor receptor
49. Nerve growth factor stimulates a protein kinase in PC-12 cells that phosphorylates microtubule-associated protein-2
50. Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF β-receptor
51. Stimulation of MAP-2 kinase activity in T lymphocytes by anti-CD3 or anti-Ti monoclonal antibody is partially dependent on protein kinase C
52. CD-3-mediated activation of MAP-2 kinase can be modified by ligation of the CD4 receptor
53. Recombinant protein production with minimal antibiotic resistance vector
54. Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts
55. Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro
56. Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo
57. After insulin binds
58. Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase
59. DNA sequencing with chain-terminating inhibitors
60. Purification and characterization of a maturation-activated myelin basic protein kinase from sea star oocytes
61. 32P into ribosomal protein S6
62. Insulinstimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II
63. Nerve growth factor and fibroblast growth factor selectively activate a protein kinase that phosphorylates high molecular weight microtubule-associated proteins
64. Signal transduction by receptors with tyrosine kinase activity
65. lck
66. Insulin stimulates a membrane-bound serine kinase that may be phosphorylated on tyrosine