Simple Methods for Estimation of Mean Residence Time and Steady-State Volume of Distribution from Continuous-Infusion Data

Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists

Volumn 8, Issue 2, 1991, Pages 254-258

  Gillespie, William R ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

intravenous infusion; mean residence time; volume of distribution at steady state

Indexed keywords

ARTICLE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG ELIMINATION; MEAN RESIDENCE TIME; STEADY STATE; THEORETICAL STUDY;

INFUSIONS, INTRAVENOUS; MODELS, BIOLOGICAL; PHARMACOKINETICS;

EID: 0025822093     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1023/A:1015860608173     Document Type: Article

References (9)

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2. Noncompartmental determination of the steady state volume of distribution for any mode of administration
3. Computation of model independent pharmacokinetic parameters during multiple dosing
4. Noncompartmental determination of the steady state volume of distribution during multiple dosing
5. The urinary elimination “time lag”: Determination of the mean residence time from drug accumulation in the urine during infusion
6. Concept of a volume of distribution and possible errors in evaluation of this parameter
7. Simplified method for estimating volume of distribution at steady state
8. On the theory of the indicator-dilution method for measurement of blood flow and volume
9. Curve fitting and modeling in pharmacokinetics and some practical experiences with NONLIN and a new program FUNFIT