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1
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0024353079
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TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties
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(1989)
Annu Rev Immunol
, vol.7
, pp. 145-173
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Mosmann1
Coffman2
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2
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0023934039
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Human Naive and Memory T Cells: Reinterpretation of Helper-Inducer and Suppressor-Inducer Subsets
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(1988)
Immunol Today
, vol.9
, pp. 195-199
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Sanders1
Makgoba2
Shaw3
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4
-
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0024354162
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Definition of the Thymic Generative Lineage by Selective Expression of High Molecular Isoforms of CD45 (T200)
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of interest, Distribution of various isoforms of CD45 on human thymocyte subsets and a model in which high-molecular-weight isoforms distinguish cells that survive the selective process.
-
(1989)
Eur J Immunol
, vol.19
, pp. 589-597
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Pilarski1
Gillitzer2
Zola3
Shortman4
Scollay5
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5
-
-
0025058905
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In situ Localization of CD45 Isoforms in the Human Thymus Indicates a Medullary Location for the Thymic Generative Lineage
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(1990)
J Immunol
, vol.144
, pp. 66-74
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Gillitzer1
Pilarski2
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6
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0025265028
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Cell Generation within Human Thymic Subsets Defined by Selective Expression of CD45 (T200) Isoforms
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(1990)
Hum Immunol
, vol.27
, pp. 333-347
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Egerton1
Pruski2
Pilarski3
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7
-
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45149141942
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Leukocyte cell surface enzymology: CD45 (LCA, T200) is a protein tyrosine phosphatase
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(1989)
Immunology Today
, vol.10
, pp. 225-228
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Clark1
Ledbetter2
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8
-
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0023690608
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Developmentally Ordered Appearance of Thymocytes Expressing Different T-Cell Antigen Receptors
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(1988)
Nature
, vol.335
, pp. 443-445
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Havran1
Allison2
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9
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0024409954
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The Structure, Function and Molecular Genetics of the γ/δ T Cell Receptor
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(1989)
Annu Rev Immunol
, vol.7
, pp. 175-207
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Raulet1
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10
-
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0025166299
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+ Dendritic Epidermal Cells of Adult Mice from Fetal Thymic Precursors
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γ3 expressing dendritic epidermal cells found in adult mice are derived from the fetal thymus.
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(1990)
Nature
, vol.344
, pp. 68-70
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Havran1
Allison2
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12
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0025062703
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A Developmental Switch in Thymic Lymphocyte Maturation Potential Occurs at the Level of Hematopoietic Stem Cells
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γ3 expressing progeny. Microenvironments are also different.
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(1990)
Cell
, vol.62
, pp. 863-874
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Ikuta1
Kina2
Macneil3
Uchida4
Peault5
Chien6
Weissman7
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14
-
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0024998637
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Intrathymic Proliferation of Perinatal Mouse αβ and γδ T Cell Receptor-Expressing Mature T Cells
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+ cells in neonatal mouse thymus are proliferating, unlike those of the adult.
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(1990)
Int Immunol
, vol.2
, pp. 859-867
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Ceredig1
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16
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0024319834
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Cell Proliferation and Differentiation in the Fetal and Early Postnatal Moose Thymus
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of interest, A new wave of proliferation of early thymocytes is seen in the 3-day-old neonatal mouse
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(1989)
J Immunol
, vol.142
, pp. 3369-3377
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Penit1
Vasseur2
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17
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0024344037
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− T Cells Bearing αβ T Cell Receptor
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− precursors, and the mature progeny have a shorter lifespan in the periphery.
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(1989)
J Immunol
, vol.142
, pp. 3773-3780
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-
Guidos1
Weissman2
Adkins3
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19
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0025041439
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1 Mice
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of interest, Autoreactive neonatal thymocytes that are deleted in adults may be present and proliferating in neonates.
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(1990)
Int Immunol
, vol.2
, pp. 869-877
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Ceredig1
Waltzinger2
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23
-
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0023621902
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An Intermediate Cell in Thymocyte Differentiation that Expresses CD8 but not CD4 Antigen
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(1987)
J Exp Med
, vol.166
, pp. 1603-1608
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Paterson1
Williams2
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30
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0025607947
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Lineage Relationships and Developmental Kinetics of Immature Thymocytes: CD3, CD4 and CD8 Acquisition In Vivo and In Vitro
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of interest, Precise timing of early developmental events in non-irradiated murine thymuses in vivo.
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(1990)
J Exp Med
, vol.172
, pp. 1583-1588
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Petrie1
Hugo2
Scollay3
Shortman4
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32
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0025646655
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Development of Immature Thymocytes: Initiation of CD3, CD4, and CD8 Acquisition Parallels Down-Regulation of the Interleukin-2-Receptor α-Chain
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(1990)
Eur J Immunol
, vol.20
, pp. 2813-2815
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-
Petrie1
Pearse2
Scollay3
Shortman4
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34
-
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0025324947
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Study of the Thymocyte Cell Cycle by Bivariate Analysis of Incorporated Bromodeoxyuridine and DNA Content
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of interest, Cell kinetic analysis of adult murine thymus. Intrathymic cell death occurs mostly in non-dividing cells.
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(1990)
Eur J Immunol
, vol.20
, pp. 1231-1236
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Baron1
Penit2
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35
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0025325471
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The Kinetics of Immature Murine Thymocyte Development in vivo
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of interest, Describes cell kinetic analysis of immature murine thymocytes, as well as the division rate and lifespan of the major early thymocyte subsets.
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(1990)
Int Immunol
, vol.2
, pp. 501-507
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Egerton1
Shortman2
Scoliay3
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36
-
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0025320656
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The Kinetics of Mature T-Cell Development in the Thymus
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+ stage and that the production rate of mature cells is very close to the measured export rate.
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(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 2579-2582
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Egerton1
Scollay2
Shortman3
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37
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0022529559
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In vivo Thymocyte Maturation. BUdR Labeling of Cycling Thymocytes and Phenotypic Analysis of their Progeny Support the Single Lineage Model
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(1986)
J Immunol
, vol.137
, pp. 2115-2121
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Penit1
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39
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0025173280
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Expression of T Cell Receptor Genes in the Thymus: Localization of Transcripts in situ and Comparison of Mature and Immature Subsets
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of outstanding interest, In situ hybridization analysis of TCR α, β, γ and δ chain mRNA expression in the thymus. Precise description of the number of cells expressing each chain in various subsets and the thymic locations.
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(1990)
Eur J Immunol
, vol.20
, pp. 2133-2136
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-
Held1
Mueller2
MacDonald3
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40
-
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0024455403
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+ T Cells: One Population is Deleted by Ligation of αβTCR
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+ thymocytes include two populations with distinct responses to TCR ligation.
-
(1989)
Cell
, vol.58
, pp. 1047-1054
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-
Finkel1
Cambier2
Kubo3
Born4
Marrack5
Kappier6
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42
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0025200095
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Molecular Mechanisms for Lineage Commitment in T Cell Development
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of interest, Excellent review of lineage commitment in T-cell development.
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(1990)
Seminars in Immunol
, vol.2
, pp. 25-34
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Robey1
Fowlkes2
Pardoll3
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45
-
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0024441273
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Engagement of CD4 and CD8 Accessory Molecules is Required for T Cell Maturation
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of interest, Demonstration that CD4 or CD8 antibodies injected into adult mice block the development of the appropriate mature single-positive population.
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(1989)
J Immuno11989
, vol.143
, pp. 1467-1471
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Ramsdell1
Fowlkes2
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46
-
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0024807506
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Engagement of CD4 and CD8 Expressed on Immature Thymocytes Induces Activation of Intracellular Tyrosine Phosphorylation Pathways
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lck is enzymatically activated if the cells are treated with anti-CD4 antibodies. Effects through CD8 were not so clear-cut.
-
(1989)
J Exp Med
, vol.170
, pp. 1671-1680
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Veillette1
Zúñiga-Pflücker2
Bolen3
Kruisbeek4
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47
-
-
0024446403
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+ Thymocytes Results in Tyrosine Phosphorylation of the T-Cell Receptor Zeta Chain
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+ thymocytes, the TCR-ζ chain is maintained in a phosphorylated state by ligation of the surface CD4 molecules. Removal of thymocytes from the thymus (and therefore the ligand for CD4) results in dephosphorylation and upregulation of TCR expression.
-
(1989)
Nature
, vol.341
, pp. 651-654
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-
Nakayama1
Singer2
Hsied3
Samelson4
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48
-
-
0025264689
-
+ Thymocytes Influenced by CD4
-
of outstanding interest, Low levels of TCR on double-positive thymocytes are the result of post-translational degradation of newly synthesized TCR chains. This situation is maintained by CD4 ligation and reversed when thymocytes are released from the thymic microenvironment.
-
(1990)
Nature
, vol.344
, pp. 247-251
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-
Bonifacino1
McCarthy2
Magutre3
Nakayama4
Singer5
Klausner6
Singer7
-
49
-
-
0025175791
-
+ Cells by CD4
-
of interest, The ligand for CD4 that maintains TCR degradation in the thymus might be MHC class II, although the absence of an effect of antibodies to class II in vivo indicates that there may be other or additional ligands in vivo.
-
(1990)
Science
, vol.249
, pp. 1558-1561
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-
Nakayama1
June2
Munitz3
Sheard4
McCarthy5
Sharrow6
Samelson7
Singer8
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