Immune recognition and response to the renal interstitium

Kidney International

Volumn 39, Issue 3, 1991, Pages 518-530

  Kelly, Carolyn J ^a   Roth, David A ^a   Meyers, Catherine M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNE RESPONSE; INTERSTITIAL NEPHRITIS; KIDNEY INTERSTITIUM; PRIORITY JOURNAL; REVIEW;

ANIMAL; ANTIGENS; AUTOIMMUNITY; B-LYMPHOCYTES; BASEMENT MEMBRANE; HUMAN; IMMUNE TOLERANCE; IMMUNITY, CELLULAR; KIDNEY; KIDNEY DISEASES; NEPHRITIS, INTERSTITIAL; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES;

EID: 0025794171     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/ki.1991.60     Document Type: Article

References (172)

1. WILSON CB: Study of the immunopathogenesis of tubulointerstitial nephritis using model systems. Kidney Int 35:938-953, 1989
2. MCCLUSKEY RT: Immunologically mediated tubulo-interstitial nephritis, in Contemporary Issues in Nephrology (vol 10), edited by COTRAN RS, BRENNER BM, STEIN JN, New York, Churchill Livingstone, 1983, pp. 121-149
3. BRENTJENS JR, NOBLE B, ANDRES GA: Immunologically mediated lesions of kidney tubules and interstitium in laboratory animals and in man. Springer Semin Immunopathol 5:357-378, 1982
4. WILSON CB: Antibody reactions with native or planted glomerular antigens producing nephritogenic immune deposits or selective glomerular cell injury, in Contemporary Issues in Nephrology (vol 18), edited by WILSON CB, BRENNER BM, STEIN JH, New York, Churchill Livingstone, 1988, pp. 1-34
5. NEILSON EG: Pathogenesis and therapy of interstitial nephritis. Kidney Int 35:1257-1270, 1989
6. NEILSON EG, CLAYMAN MD, HAVERTY T, KELLY CJ, MANN R: Experimental strategies for the study of cellular immunity in renal disease. Kidney Int 30:264-279, 1986
7. DRUET P, GLOTZ D: Experimental autoimmune nephropathies: Induction and regulation. Adv Nephrol 13:115-133, 1984
8. KELLY CJ, HAVERTY T, NEILSON EG: Control of the nephritogenic immune response, in Contemporary Issues in Nephrology (vol 18), edited by WILSON CB, BRENNER BM, STEIN JH, New York, Churchill Livingstone, 1988, pp. 35-56
9. KELLY CJ: T cell regulation of autoimmune interstitial nephritis. J Am Soc Nephrol 1:140-149, 1990
10. SUGISAKI T, KLASSEN J, MILGROM F, ANDRES GA, MCCLUSKEY RT: Immunopathologic study of an autoimmune tubular and interstitial renal disease in Brown Norway rats. Lab Invest 28: 658-671, 1973
11. LEHMAN DH, WILSON CB, DIXON FJ: Interstitial nephritis in rats immunized with heterologous tubular basement membrane. Kidney Int 5:187-195, 1974
12. WILSON CB, LEHMAN DH, MCCOY RC, GUNNELLS JC, STICKEL DL: Antitubular basement membrane antibodies after renal transplantation. Transplantation 18:447-452, 1974
13. DIALYNAS DP, WILDE DB, MARRACK P, PIERRES A, WALL KA, HAVRAN W, OTTEN G, LOKEN MR, PIERRES M, KAPPLER J, FITCH FW: Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK 1.5; expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity. Immunol Rev 74:29-56, 1983
14. SWAIN SI: T cell subsets and the recognition of MHC class. Immunol Rev 74:129-142, 1983
15. + effector T cells recognize products of different major histocompatibility complex regions. Proc Natl Acad Sci USA 79:4395-4399, 1982
16. UNANUE ER, ALLEN PM: The basis for the immunoregulatory role of macrophages and other accessory cells. Science 236:551-557, 1987
17. BABBITT BP, ALLEN PM, MATSUEDA G, HABER E, UNANUE ER: Binding of immunogenic peptides to Ia histocompatibility molecules. Nature 317:359-361, 1985
18. BROWN JH, JARDETZSKY T, SAPER MA, SAMRAOUI B, BJORKMAN P, WILEY DC: A hypothetical model of the foreign antigen binding site of class II histocompatibility antigens. Nature 332:845-850, 1988
19. BJORKMAN PJ, SAPER MA, SAMRAOUI B, BENNETT WS, STROMINGER JL, WILEY DC: Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329:506-511, 1987
20. BJORKMAN PJ, SAPER MA, SAMRAOUI B, BENNETT WS, STROMINGER JL, WILEY DC: The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329:512-518, 1987
21. HINES WH, HAVERTY TP, ELIAS JA, NEILSON EG, KELLY CJ: T cell recognition of epithelial self. Autoimmunity 5:37-47, 1989
22. WUTHRICH RP, GLIMCHER LH, YUI MA, JEVNIKAR AM, DUMAS SE, KELLEY VE: MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells. Kidney Int 37:783-792, 1990
23. OLDSTONE MB: Molecular mimicry as a mechanism for the cause and a probe uncovering etiologic agent(s) of autoimmune disease. Curr Top Microbiol Immunol 145:127-135, 1989
24. MENDRICK DL, KELLY D, RENNKE HG: Antigen presentation by rat glomerular epithelial cells, (abstract) Kidney Int 37:423, 1990
25. HAVERTY TP, KELLY CJ, HINES WH, AMENTA PS, WATANABE M, HARPER RA, KEFALIDES NA, NEILSON EG: Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis. J Cell Biol 107:1359-1368, 1988
26. SAIZAWA K, ROJO J, JANEWAY CA: Evidence for a physical association of CD4 and the CD3:α/β T-cell receptor. Nature 328:260-263, 1987
27. SCHWARTZ RH: Fugue in T-lymphocyte recognition. Nature 326:738-739, 1987
28. STEIN ME, STADECKER MJ: Characterization and antigen-presenting function of a murine thyroid-derived epithelial cell line. J Immunol 139:1786-1791, 1987
29. HAVERTY TP, WATANABE M, NEILSON EG, KELLY CJ: Protective modulation of class II MHC gene expression in tubular epithelium by target antigen specific antibodies. Cell surface directed down-regulation of transcription can influence susceptibility to murine tubulointerstitial nephritis. J Immunol 143:1133-1141, 1989
30. VAN ZWIETEN MJ, LEBER PD, BHAN AK, MCCLUSKEY RT: Experimental cell-mediated interstitial nephritis induced with exogenous antigens. J Immunol 118:589-593, 1977
31. VARGAS ARENAS RE, TURNER DR: Pathology of interstitial nephritis induced in guinea pigs by exoantigens. Nephron 32:170-179, 1982
32. SUGISAKI T, YOSHIDA T, MCCLUSKEY RT, ANDRES GA, KLASSEN J: Autoimmune cell-mediated tubulointerstitial nephritis induced in Lewis rats by renal antigens. Clin Immunol Immunopathol 15:33-43, 1980
33. NEILSON EG, PHILLIPS SM: Cell-mediated immunity in interstitial nephritis. I. T lymphocyte systems in nephritis guinea pigs: The natural history and diversity of the immune response. J Immunol 123:2373-2380, 1979
34. NEILSON EG, PHILLIPS SM: Cell-mediated immunity in interstitial nephritis. II. T lymphocyte effector mechanisms in nephritis guinea pigs: Analysis of the renotropic migration and cytotoxic response. J Immunol 123:2381-2385, 1979
35. NEILSON EG, JIMINEZ SA, PHILLIPS SM: Cell-mediated immunity in interstitial nephritis. III. T lymphocyte-mediated fibroblast proliferation and collagen synthesis: An immune mechanism for renal fibrogenesis. J Immunol 125:1708-1714, 1980
36. LEHMAN DH, WILSON CB: Role of sensitized cells in antitubular basement membrane interstitial nephritis. Int Arch Allergy Appl Immunol 51:168-174, 1976
37. CLAYMAN M, MICHAUD L, NEILSON EG: Murine interstitial nephritis VI. Characterization of the B cell response in antitubular basement membrane disease. J Immunol 139:2242-2249, 1987
38. ZAKHEIM B, MCCAFFERTY E, MANN R, PHILLIPS SM, CLAYMAN M, NEILSON EG: Murine interstitial nephritis II. The adoptive transfer of disease with immune T lymphocytes produces a phenotypically complex interstitial lesion. J Immunol 133:234-239, 1984
39. NEILSON EG, MCCAFFERTY E, MANN R, MICHAUD L, CLAYMAN M: Murine interstitial nephritis. III. The selection of phenotypic (Lyt and L3T4) and idiotypic (RE-Id) T cell preferences by genes in Igh-1 and H-2K characterize the cell-mediated potential for disease expression: Susceptible mice provide a unique effector T cell repertoire in response to tubular antigen. J Immunol 134:2375-2382, 1985
40. NEILSON EG, PHILLIPS SM: Murine interstitial nephritis I. Analysis of disease susceptibility and its relationship to pleiomorphic gene products defining both immune-response genes and a restrictive requirement for cytotoxic T cells at H-2K. J Exp Med 155:1075-1085, 1982
41. + T cell lines transfer delayed expression of disease as I-A-restricted inducers of the effector T cell repertoire. J Immunol 135:286-293, 1985
42. HINES WH, MANN RA, KELLY CJ, NEILSON EG: Murine interstitial nephritis. IX. Induction of the nephritogenic effector T cell repertoire with an antigen-specific T cell cytokine. J Immunol 144:75-83, 1990
43. + regulatory T cells. J Immunol 136:4200-4208, 1987
44. KELLY CJ, MOK H, NEILSON EG: The selection of effector T cell phenotype by contrasuppression modulates susceptibility to autoimmune injury. J Immunol 141:3022-3028, 1988
45. MEYERS CM, KELLY CJ: An antigen-specific CTL line transfers interstitial nephritis and is cytotoxic to antigen-expressing tubular epithelial cells, (abstract) Kidney Int 37:423, 1990
46. SAAD T, MANDELBROT D, SUN MJ, KELLY CJ, HINES WH, NEILSON EG: Isolation of cDNA for the antigen-binding chain of a helper T cell factor in murine interstitial nephritis, (abstract) Kidney Int 37:430, 1990
47. LYON MF, HULSE EV: An inherited kidney disease of mice resembling human nephronophthisis. J Med Genetics 8:41-48, 1971
48. NEILSON EG, MCCAFFERTY E, FELDMAN A, CLAYMAN MD, ZAKHEIM B, KORNGOLD R: Spontaneous interstitial nephritis in kdkd mice. I. An experimental model of autoimmune renal disease. J Immunol 133:2560-2565, 1984
49. FERNANDES G, YUNIS EJ, MIRANDA M, SMITH J, GOOD RA: Nutritional inhibition of genetically determined renal disease and autoimmunity with prolongation of life in kdkd mice. Proc Natl Acad Sci USA 75:2888-2892, 1978
50. + effector T cell that mediates destructive tubulointerstitial injury. J Immunol 136:526-531, 1986
51. BANNISTER KM, ULICH TR, WILSON CB: Induction, characterization, and cell transfer of autoimmune tubulointerstitial nephritis in the Lewis rat. Kidney Int 32:642-651, 1987
52. NATHAN C: Secretory products of macrophages. J Clin Invest 79:319-26, 1987
53. SPORN MB, ROBERTS AB: Peptide growth factors are multifunctional. Nature 332:217-219, 1988
54. ROBERTS AB, SPORN MB, ASSOIAN RK, SMITH JM, ROCHE NS, WAKEFIELD LM, HEINE UI, LIOTTA LA, FALANGA V, KEHRL JH, FAUCI AS: Transforming growth factor type β: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 83:4167-4171, 1986
55. MIZEL SB, DAYER J-M, KRANE SM, MERGENHAGEN SE: Stimulation of rheumatoid synovial cell collagnease and prostaglandin production by partially purified lymphocyte activating factor (interleukin 1). Proc Natl Acad Sci USA 78:2474-2477, 1981
56. BEUTLER B, CERAMI A: Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature 320:584-588, 1986
57. MASSON D, TSCHOPP J: A family of serine esterases in lytic granules of cytolytic T lymphocytes. Cell 49:679-685, 1987
58. GERSHENFELD HK, WEISSMAN IL: Cloning of a cDNA for a T cell-specific serine protease from a cytotoxic T lymphocyte. Science 232:854-858, 1986
59. PODACK ER, YOUND JD-E, COHN ZA: Isolation and biochemical and functional characterization of perform 1 from cytolytic T cell granules. Proc Natl Acad Sci USA 82:8629-8633, 1985
60. ZALMAN LS, MARTIN DE, JUNG G, MULLER-EBERHARD HJ: The cytolytic protein of human lymphocytes related to the ninth component (C9) of human complement: Isolation from anti-CD3 activated peripheral blood mononuclear cells. Proc Natl Acad Sci USA 84:2426-2429, 1987
61. LOWREY DM, AEBISCHER T, OLSEN K, LICHTENHELD M, RUPP F, PODACK ER: Cloning, analysis, and expression of murine perform 1 cDNA, a component of cytolytic T cell granules with homology to complement component C9. Proc Natl Acad Sci USA 86:247-251, 1989
62. + lymphocytes in autoimmune disease. Studies on spontaneous and adoptively transferred diabetes in nonobese diabetic mice. J Immunol 143:3994-3999, 1989
63. SLOPER JC, DE WARDNER H, WOODROW DF: Relationship between renal structure and function deduced from renal biopsies, in Renal Patholphysiology-Recent Advances, edited by LEAF A, GIEBISCH G, BOLIS L, GORINI, New York, Raven Press, 1980, pp. 109-120
64. BOHLE A, MACKENSEN-HAEN S, GISE HV: Significance of tubulointerstitial changes in the renal cortex for the excretory function and concentrating ability of the kidney: A morphometric contribution. Am J Nephrol 7:421-433, 1987
65. TATSCH K, LEISNER B, THOENES GH, MASON J: The importance of the renal interstitium for kidney function. Contrib Nephrol 56:53-59, 1987
66. ALEXOPOULOS E, SERON D, HARTLEY RB, CAMERON JS: Lupus nephritis: correlation of interstitial cells with glomerular function. Kidney Int 37:100-109, 1990
67. EDDY AA, MICHAEL AF: Acute tubulointerstitial nephritis associated with aminonucleoside nephrosis. Kidney Int 33:14-23, 1988
68. EDDY AA: Interstitial nephritis induced by protein-overload proteinuria. Am J Pathol 135:719-733, 1989
69. EDDY AA, MCCULLOCH L, LIU E: A relationship between proteinuria and acute tubulointerstitial disease in experimental nephrosis. (abstract) Kidney Int 37:412, 1990
70. NEILSON EG, CLAYMAN MD, KELLY CJ: The immunopathogenesis of interstitial nephritis, in Textbook of Nephrology, edited by MASSRY S, GLASSOCK R, Baltimore, Williams and Wilkins, 1988, pp. 1284-1293
71. CAMERON JS: Allergic interstitial nephritis: Clinical features and pathogenesis. Quart J Med New Series 66, 250:97-115, 1988
72. APPEL GB, KUNIS CL: Acute tubulointerstitial nephritis, in Tubulointerstitial nephropathies, edited by COTRAN RS, New York, Churchill-Livingstone, 1983, pp. 151-185
73. ELLIS D, FRIED WA, YUNIS EJ, BLAU EB: Acute interstitial nephritis in children: A report of 13 cases and review of the literature. Pediatrics 67:862-870, 1981
74. PARK MH, D'AGATI V, APPEK GB, PIRANI CL: Tubulointerstitial disease in lupus nephritis: Relationship to immune deposits, interstitial inflammation, glomerular changes, renal function, and progression. Nephron 44:309-319, 1986
75. BALDWIN DS, LEVINE BB, MCCLUSKEY RT, GALLO GR: Renal failure and interstitial nephritis due to penicillin and methicillin. N Engl J Med 279:1245-1252, 1968
76. BRENTJENS JR, SEPULVEDA M, BALIAH T, BENTZEL C, ERLANGER BF, ELWOOD C, MONTES M, HSU KC, ANDRES GA: Interstitial immune complex nephritis in patients with systemic lupus erythematosus. Kidney Int 7:342-350, 1975
77. MCLEISH KR, SENITZER D, GOHARA AF: Acute interstitial nephritis in a patient with aspirin hypersensitivity. Clin Immunol Immunopathol 14:64-69, 1979
78. CHENG H-F, NOLASCO F, CAMERON JS, HILDRETH G, NEILD G, HARTLET B: HLA-DR display by renal tubular epithelium and phenotype of infiltrate in interstitial nephritis. Nephrol Dial Transplant 4:205-215, 1989
79. HUSBY G, TUNG KSK, WILLIAMS RC: Characterization of renal tissue lymphocytes in patients with interstitial nephritis. Am J Med 70:31-38, 1981
80. STACHURA I, SI L, MADAN E, WHITESIDE T: Mononuclear cell subsets in human renal disease. Enumeration in tissue sections with monoclonal antibodies. Clin Immunol Immunopathol 30:362-373, 1984
81. BENDER WL, WHELTON A, BESCHORNER WE, DARWISH MOP, HALL-CRAGGS M, SOLEZ K: Interstitial nephritis, proteinuria, and renal failure caused by nonsteroidal anti-inflammatory drugs. Immunologic characterization of the inflammatory infiltrate. Am J Med 76:1006-1012, 1984
82. ROSENBERG ME, SCHENDEL PB, MCCURDY FA, PLATT JL: Characterization of immune cells in kidneys from patients with Sjögren's syndrome. Am J Kidney Dis 11:20-22, 1988
83. BOUCHER A, DROZ D, ADAFER E, NOEL LH: Characterization of mononuclear cell subsets in renal cellular interstitial infiltrates. Kidney Int 29:1043-1049, 1986
84. ZAGER RA, COTRAN RS, HOYER JR: Pathologic localization of Tamm-Horsfall protein in interstitial deposits in renal disease. Lab Invest 38:52-57, 1978
85. STEBLAY RW, RUDOFSKY U: Transfer of experimental autoimmune renal cortical tubular and interstitial disease in guinea pigs by serum. Science 180:966-968, 1973
86. LEHMAN DH, MARQUARDT H, WILSON CB, DIXON FJ: Specificity of autoantibodies to tubular and glomerular basement membranes induced in guinea pigs. J Immunol 112:241-248, 1974
87. VAN ZWIETEN MJ, BHAN AK, MCCLUSKEY RT, COLLINS AB: Studies on the pathogenesis of experimental anti-tubular basement membrane nephritis in the guinea pig. Am J Pathol 83:531-546, 1976
88. HALL CL, COLVIN RB, CAREY K, MCCLUSKEY RT: Passive transfer of autoimmune disease with isologous IgG1 and IgG2 antibodies to the tubular basement membrane in strain XIII guinea pigs. Loss of self-tolerance induced by autoantibodies. J Exp Med 146:1246-1260, 1977
89. ZANETTI M, WILSON CB: Characterization of anti-tubular basement membrane antibodies in rats. J Immunol 130:2173-2179, 1983
90. NEILSON EG, ZAKHEIM B: T cell regulation, anti-idiotypic immunity, and the nephritogenic immune response. Kidney Int 24:289-302, 1983
91. BROWN CA, CAREY K, COLVIN RB: Inhibition of autoimmune tubulointerstitial nephritis in guinea pigs by heterologous antisera containing anti-idiotype antibodies. J Immunol 123:2102-2107, 1979
92. CLAYMAN MD, SUN MJ, MICHAUD L, BRILL-DASHOFF J, RIBLET R, NEILSON EG: Clonotypic heterogeneity in experimental interstitial nephritis. Restricted specificity of the anti-tubular basement membrane B cell repertoire is associated with a disease-modifying crossreactive idiotype. J Exp Med 167:1296-1312, 1988
93. STEBLAY RW, RUDOFSKY U: Renal tubular disease and autoantibodies against tubular basement membrane induced in guinea pigs. J Immunol 107:589-594, 1971
94. + suppressor T cells specific for autologous renal tubular antigen in experimental interstitial nephritis. J Exp Med 162:1892-1903, 1985
95. LEHMAN DH, LEE S, WILSON CB, DIXON FJ: Induction of antitubular basement membrane antibodies in rats by renal transplantation. Transplantation 17:429-431, 1974
96. NEILSON EG, GASSER DL, MCCAFFERTY E, ZAKHEIM B, PHILLIPS SM: Polymorphism of genes involved in anti-tubular basement membrane disease in rats. Immunogenetics 17:555-565, 1983
97. MATSUMOTO K, MCCAFFERTY E, NEILSON EG, GASSER DL: Mapping of the genes for tubular basement membrane antigen and a submaxillary gland protease in the rat. Immunogenetics 20:117-123, 1984
98. HART DJ, FABRE JW: Kidney-specific alloantigen system in the rat. Characterization and role in transplantation. J Exp Med 151:651-666, 1980
99. KRIEGER A, THOENES GH, GUNTHER E: Genetic control of autoimmune tubulointerstitial nephritis in rats. Clin Immunol Immunopathol 21:301-308, 1981
100. CLAYMAN MD, MARTINEZ-HERNANDEZ A, MICHAUD L, ALPER R, MANN R, KEFALIDES NA, NEILSON EG: Isolation and characterization of the nephritogenic antigen producing anti-tubular basement membrane disease. J Exp Med 161:290-305, 1985
101. CLAYMAN MD, MICHAUD L, BRENTJENS J, ANDRES GA, KEFALIDES NA, NEILSON EG: Isolation of the target antigen in human anti-tubular basement membrane nephritis. J Clin Invest 77:1143-1147, 1986
102. FLIGER FD, WIESLANDER J, BRENTJENS JR, ANDRES GA, BUTKOWSKI RJ: Identification of a target antigen in human anti-tubular basement membrane nephritis. Kidney Int 31:800-807, 1987
103. WAKASHIN M, WAKASHIN Y, UEDA S, TAKEI I, MORI Y, MORI T, IESATO K, OKUDA K: Murine autoimmune interstitial nephritis and associated antigen: Purification of a soluble tubular basement membrane antigen from mice kidneys. Renal Physiol 3:360-367, 1980
104. NEILSON EG, SUN MJ, KELLY CJ, HINES WH, HAVERTY TP, CLAYMAN MD, COOKE NE: Molecular characterization of a major nephritogenic domain in the autoantigen of anti-tubular basement membrane disease, (abstract) Kidney Int 35:358, 1989
105. RUDOFSKY UH, STEBLAY RW, POLLARA B: Inhibition of experimental autoimmune renal tubulointerstitial disease in guinea pigs by depletion of complement with cobra venom factor, Clin Immunol Immunopathol 3:396-407, 1975
106. BANNISTER KM, WILSON CB: Transfer of tubulointerstitial nephritis in the Brown Norway rat with anti-tubular basement membrane antibody: Quantitation and kinetics of binding and effect of decomplementation. J Immunol 135:3911-3917, 1985
107. NEILSON EG, PHILLIPS SM: Cell-mediated immunity in interstitial nephritis. IV. Anti-tubular basement membrane antibodies can function in antibody-dependent cellular cytotoxicity reactions: Observations on a nephritogenic effector mechanism acting as an informational bridge between the humoral and cellular immune response. J Immunol 126:1990-1993, 1981
108. NATH KA, HOSTETTER MK, HOSTETTER TH: Pathophysiology of chronic tubulo-interstitial disease in rats. Interactions of dietary acid load, ammonia, and complement component C3. J Clin Invest 76:667-675, 1985
109. WILSON CB, DIXON FJ: Anti-glomerular basement membrane antibody-induced glomerulonephritis. Kidney Int 3:74-89, 1973
110. LEHMAN DH, WILSON CB, DIXON FJ: Extraglomerular immunoglobulin deposits in human nephritis. Am J Med 58:765-786, 1975
111. BORDER WA, LEHMAN DH, EGAN JD, SASS HJ, GLODE JE, WILSON CB: Antitubular basement-membrane antibodies in methicillin-associated interstitial nephritis. N Engl J Med 291:381-384, 1974
112. HYMAN LR, BALLOW M, KNIESER MR: Diphenylhydantoin interstitial nephritis. Roles of cellular and humoral immunologic injury. J Pediatr 92:915-920, 1978
113. NEILSON EG, PHILLIPS SM: Suppression of interstitial nephritis by auto-anti-idiotypic immunity. J Exp Med 155:179-189, 1982
114. - suppressor T cell mechanism. J Exp Med 159:1009-1026, 1984
115. ANDREWS BS, EISENBERG RA, THEOFILOPOULOS AN, IZUI S, WILSON CB, MCCONAHEY PJ, MURPHY ED, ROTHS JB, DIXON FJ: Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med 148:1198-1215, 1978
116. MAKKER SP: Tubular basement membrane antibody-induced interstitial nephritis in systemic lupus erythematosus. Am J Med 69:949-952, 1980
117. GUR H, KOPOLOVIC Y, GROSS DJ: Chronic predominant interstitial nephritis in a patient with systemic lupus erythematosus: A follow-up of three years and review of the literature. Ann Rheum Dis 46:617-623, 1987
118. KERJASCHKI D, FARQUHAR MG: The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proc Natl Acad Sci USA 79:5557-5561, 1982
119. HOYER JR, SEILER MW: Pathophysiology of Tamm-Horsfall protein. Kidney Int 16:279-289, 1979
120. KLASSEN J, SUGISAKI T, MILGROM F, MCCLUSKEY RT: Studies on multiple renal lesions in Heymann nephritis. Lab Invest 25: 577-585, 1971
121. GRONHAGEN-RISKA C, VON-WILLEBRAND E, TIKKANEN T, HONKANEN E, MIETTINEN A, HOLTHOFER H, TORNROTH T: The effect of cyclosporin A on the interstitial mononuclear cell infiltration and the induction of Heymann's nephritis. Clin Exp Immunol 79:266-272, 1990
122. NOBLE B, MENDRICK DL, BRENTJENS JR, ANDRES GA: Antibody-mediated injury to proximal tubules in the rat kidney induced by passive transfer of homologous anti-brush border serum. Clin Immunol Immunopathol 19:289-301, 1981
123. NOBLE B, ANDRES GA, BRENTJENS JR: Passively transferred anti-brush border antibodies induce injury of proximal tubules in the absence of complement. Clin Exp Immunol 56:281-288, 1983
124. ISHIDATE T, HOYER JR, SEILER MW: Influence of altered glomerular permeability on renal tubular immune complex formation and clearance. Lab Invest 49:582-588, 1983
125. SEILER MW, HOYER JR: Ultrastructural studies of tubulointerstitial immune complex nephritis in rats immunized with Tamm-Horsfall protein. Lab Invest 45:321-327, 1981
126. FASTH A, HOYER JR, SEILER MW: Renal tubular immune complex formation in mice immunized with Tamm-Horsfall protein. Am J Pathol 125:555-562, 1986
127. MAYRER AR, KASHGARIAN M, RUDDLE NH, MARIER R, HODSON CJ, RICHARD EF, ANDRIOLE VT: Tubulointerstitial nephritis and immunologic responses to Tamm-Horsfall protein in rabbits challenged with homologous urine or Tamm-Horsfall protein. J Immunol 128:2634-2642, 1982
128. NOSSAL GJV: Immunologic tolerance: Collaboration between antigen and lymphokines. Science 245:147-153, 1989
129. KAPPLER JW, ROEHM N, MARRACK P: T cell tolerance by clonal elimination in the thymus. Cell 49:273-280, 1987
130. GOODNOW CC, CROSBIE J, ADELSTEIN S, LAVOIE TB, SMITHGILL SJ, BRINK RA, PRITCHARD-BRISCOE H, WOTHERSPOON JS, LOBLAY RH, RAPHAEL K, TRENT RJ, BASTEN A: Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334:676-682, 1988
131. BURKLY LC, LO D, FLAVELL RA: Tolerance in transgenic mice expressing major histocompatibility molecules extrathymically on pancreatic cells. Science 248:1364-1368, 1990
132. SCHWARTZ RH: A cell culture model for T lymphocyte clonal anergy. Science 248:1349-1356, 1990
133. KELLY CJ, NEILSON EG: Contrasuppression in autoimmunity Abnormal contrasuppression facilitates expression of nephritogenic effector T cells and interstitial nephritis in kdkd mice. J Exp Med 165:107-123, 1987
134. KRAKAUER RS, WALDMANN TA, STROBER W: Loss of suppressor T cells in adult NZB/NZW mice. J Exp Med 144:662-673, 1976
135. GERSHON RK, EARDLEY DD, DURUM S, GREEN DR, SHEN FW, YAMAUCHI K, CANTOR H, MURPHY DB: Contrasuppression. A novel immunoregulatory activity. J Exp Med 153:1533-1546, 1981
136. IVERSON M, PTAK W, GREEN DR, GERSHON RK: Role of contrasuppression in the adoptive transfer of immunity. J Exp Med 158:982-987, 1983
137. BRALEY-MULLEN H: Regulation of the antibody response to type II pneumococcal polysaccharide by contrasuppressor T cells. J Exp Med 160:42-54, 1984
138. SUZUKI I, KIYONO H, KITAMURA K, GREEN DR, MCGHEE JR: Abrogation of oral tolerance by contrasuppressor T cells suggests the presence of regulatory T cell networks in the mucosal immune system. Nature (London) 320:451-454, 1986
139. FLOOD PM, FRIEDMAN A, FREEDMAN J, HORVAT B, REUTER P, PTAK W: The role of contrasuppression in tumor regression. Immunol Res 7:12-22, 1988
140. LEHNER T, BRINES R: Phenotypic and functional characterization of human contrasuppressor cell interactions. Immunol Res 7:33-44, 1988
141. LEE S-T, PARASKEVAS F, MAEBA J: Activation in vivo of a major antisuppressor T cell pathway immediately after immunization. II. T cell requirements for its expression. Cell Immunol 92:64-73, 1985
142. PTAK W, BERETA M, MARCINKIEWICZ J, GERSHON RK, GREEN DR: Production of antigen-specific contrasuppressor cells and factor, and their use in augmentation of cell-mediated immunity. J Immunol 133:623-628, 1984
143. 4 lectin from Vicia Villosa seeds interacts with N-acetylgalactosamine residues α-linked to serine or threonine residues in cell surface glycoproteins. J Biol Chem 258:5172-5176, 1983
144. KELLY CJ, NEILSON EG: Medullary cystic disease: An inherited form of autoimmune interstitial nephritis? Am J Kidney Dis 10:389-395, 1987
145. AGUS D, MANN R, CLAYMAN M, KELLY C, MICHAUD L, COHN D, NEILSON EG: The effects of daily cyclophosphamide administration on the development and extent of primary experimental interstitial nephritis in rats. Kidney Int 29:635-640, 1986
146. SHIH W, HINES WH, NEILSON EG: Effects of cyclosporin A on the development of immune-mediated interstitial nephritis. J Clin Invest 79:782-789, 1987
147. GIMENEZ A, LEYVA-COBIAN F, FIERRO C, RIO M, BRICIO T, MAMPASO F: Effect of cyclosporine A on autoimmune tubulointerstitial nephritis in the Brown Norway rat. Clin Exp Immunol 69:550-556, 1987
148. THOENES GH, UMSCHEID T, SITTER T, LANGER KH: Cyclosporine A inhibits autoimmune experimental tubulointerstitial nephritis. Immunol Lett 15:301-306, 1987
149. 1 inhibits effector T cell induction and tissue damage in experimental murine interstitial nephritis. J Clin Invest 79:782-789, 1987
150. 1 on the induction of the humoral immune response and the elicitation of humorally mediated inflammation. Am J Pathol 124:286-293, 1986
151. SY MS, MILLER SD, CLAMAN HN: Immune suppression with supraoptimal doses of antigen in contact sensitivity. I. Demonstration of suppressor cells and their sensitivity to cyclophosphamide. J Immunol 119:240-244, 1977
152. 1 hybrid mice. Arthritis Rheum 20:1449-1456, 1977
153. KELLEY VE, WINKELSTEIN A, IZUI S: Effect of prostaglandin E on immune complex nephritis in NZB/W mice. Lab Invest 41:531-537, 1979
154. ALEXANDER NJ, SMYTHE NL, JOKINEN MP: The type of dietary fat affects the severity of autoimmune disease in NZB/NZW mice. Am J Pathol 127:106-121, 1987
155. 1 mice by treatment with monoclonal antibody to L3T4. J Immunol 138:3247-3253, 1987
156. 1 mice with monoclonal antibody to L3T4. J Exp Med 161:378-391, 1986
157. 1 disease with anti-IA monoclonal antibodies. J Exp Med 158:1350-1355, 1987
158. MCDEVITT HO, PERRY R, STEINMAN LA: Monoclonal anti-IA antibody therapy in animal models of autoimmune disease. Ciba Foundation Symposia 129:184-193, 1987
159. WUTHRICH RP, YUI MA, MAZOUJIAN G, NABAVI N, GLIMCHER LH, KELLEY VE: Enhanced MHC class II expression in renal proximal tubules precedes loss of renal function in MRL/lpr mice with lupus nephritis. Am J Pathol 134:45-51, 1989
160. HALLORAN PF, JEPHTHAH-OCHOLA J, URMSON J, FARKAS S: Systemic immunologic stimuli increase class I and class II antigen expression in mouse kidney. J Immunol 135:1053-1060, 1985
161. HALLORAN PF, AUTENRIED P, WADGYMAR A: Regulation of HLA antigen expression in human kidney, in Clinical Immunology Allergy (vol 6), edited by CARPENTER CB, Philadelphia, WB Saunders Co, 1986, pp. 411-435
162. STROM TB, KELLEY VE: Toward more selective therapies to block undesired immune responses. Kidney Int 35:1026-1033, 1989
163. KELLEY VE, GAULTON GN, HATTORI M, IKEGAMI H, EISENBARTH G, STROM TB: Anti-interleukin 2 receptor antibody suppresses murine diabetic insulitis and lupus nephritis. J Immunol 40:59-61, 1988
164. KIRKMAN RL, BARRETT LV, GAULTON GN, KELLEY VE, YTHIER A, STROM TB: Administration of an anti-interleukin receptor monoclonal antibody prolongs cardiac allograft survival in mice. J Exp Med 162:358-362, 1985
165. WILLIAMS DP, PARKER K, BACHA P, BISHAI W, BOROWSKI M, GENBAUFFE F, STROM TB, MURPHY JR: Diphtheria toxin receptor binding domain substitution with interleukin-2: Genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein. Protein Engineer 1:493-498, 1987
166. BACHA P, WILLIAMS DP, WATERS C, WILLIAMS JM, MURPHY JR, STROM TB: Interleukin 2 receptor targeted cytotoxicity. J Exp Med 167:612-622, 1988
167. + suppressor T cells which are antigen specific and inhibit the expression of disease. J Immunol 136:903-907, 1986
168. NEILSON EG, MCCAFFERTY E, MANN R, MICHAUD L, CLAYMAN M: Tubular antigen derivatized cells induce a disease protective, antigen-specific, and idiotype-specific suppressor T cell network restricted by IJ and Igh-V in mice with experimental interstitial nephritis. J Exp Med 162:215-230, 1985
169. NEILSON EG, KELLY CJ, CLAYMAN MD, HINES WH, HAVERTY T, SUN MJ, BLANCHARD N: Murine interstitial nephritis VII. Suppression of renal injury following treatment with soluble suppressor factor TsF1. J Immunol 139:1518-1535, 1987
170. + suppressor T cells diminishes the expression of interstitial nephritis in mice with antitubular basement membrane disease. J Immunol 136:908-912, 1986
171. KELLY CJ, CLAYMAN MD, HINES WH, NEILSON EG: Therapeutic immune regulation in experimental interstitial nephritis with suppressor T cells and their soluble factors. Ciba Foundation Symposia 129:73-87, 1987
172. UEDA S, WAKASHIN M, WAKASHIN Y, MORI T, YOSHIDA H, MORI Y, IESATO K, OGAWA M, AZEMOTO R, KATO I: Suppressor system in murine interstitial nephritis. Analysis of tubular basement (TBM)-specific suppressor T cells and their soluble factor in C57BL/6 mice using a syngeneic system. Clin Immunol Immunopathol 45:78-91, 1987