Insulin attenuation of vasoconstrictor responses to phenylephrine in zucker lean ana obese rats

American Journal of Hypertension

Volumn 4, Issue 6, 1991, Pages 537-539

  Zemel, Michael B ^b,c   Reddy, Sridhar ^a   Sowers, James R ^a,b  

^a WAYNE STATE UNIVERSITY   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Insulin resistance; Obesity; Vascular re activity

Indexed keywords

INSULIN; PHENYLEPHRINE;

ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; INSULIN RESISTANCE; MALE; OBESITY; RAT; VASOCONSTRICTION;

ANIMAL; COMPARATIVE STUDY; HYPERTENSION; INSULIN; INSULIN RESISTANCE; MALE; OBESITY; PHENYLEPHRINE; RATS; RATS, ZUCKER; SUPPORT, U.S. GOV'T, NON-P.H.S.; VASOCONSTRICTION;

EID: 0025793286     PISSN: 08957061     EISSN: 19417225     Source Type: Journal    
DOI: 10.1093/ajh/4.6.537     Document Type: Article

References (15)

1. Shehin SE, Sowers JR, Zemel MB: Impaired vascularsmooth muscle 45Ca efflux and hypertension in Zuckerobese rats. J Vase Med Biol 1989;1:278-282.
2. Zemel MB, Sowers JR, Shehin S, et al: Impaired calciummetabolism associated with hypertension in Zuckerobese rats. Metabolism 1990;39:704-708.
3. Zemel MB, Shehin S, Reddy S, et al: Vascular reactivityin Zucker obese rats: role of insulin resistance (abst). Hypertension 1989;14:358.
4. Landsberg L, Krieger DR: Obesity, metabolism and thesympathetic nervous system. Am J Hypertens 1989;2:125S-132S.
5. DeFronzo RA, Cooke CR, Andres R, et al: The effect ofinsulin on renal handling of sodium, potassium, calciumand phosphate in man. J Clin Invest 1975;55:845-855.
6. Levy J, Zemel MB, Sowers J: Role of cellular calciummetabolism in abnormal glucose metabolism and diabetic hypertension. Am J Med 1989;87(suppl 6A):7S-22S.
7. Zemel MB, Standley PR, Hodarek M, et al: Insulin stimulates vascular smooth muscle (VSM) 45Ca efflux and attenuates VSM cell (VSMC) intracellular Ca2+ ([Ca2+]i)responses to arginine vasopressin. Endocrine Society Annual Meeting Abstracts, Atlanta June 21, 1990.
8. Zierler K, Wu FS: Insulin acts on Na, K, and Ca currents.Trans Assoc Am Phys 1988;101:320-325.
9. Mathias CJ, DaCosta DF, Fosbraey P, et al: Hypotensiveand sedative effects of insulin in autonomic failure. BrMed J 1987;295:161-163.
10. Reddy S, Shehin S, Sowers JR, et al: Aortic calcium-45flux and blood pressure regulation in streptozotocin-in-duced diabetic rats. J Vase Med Biol 1990;2:47-51.
11. Field FP, Soltis EE: Vascular reactivity in the spontaneously hypertensive rat: high pressure stress and extracellular calcium. Hypertension 1985;7:228-235.
12. Kurtz TW, Morris RC, Pershadsingh HA: The Zuckerfatty rat as a genetic model of obesity and hypertension.Hypertension 1989;3:896-901.
13. Zemel MB, Bedford BA, Zemel PC, et al: Altered cationtransport in non-insulin-dependent diabetic hypertension: effects of dietary calcium. J Hypertens 1988;6(suppl4):s228-s300.
14. Christlieb AB, Krolewski AS, Warrant JH, Soeldner JS: Isinsulin the link between hypertension and obesity? Hypertension 1985;7(suppl 2):54-57.
15. Hall JE, Brands MW, Kivlighn S, et al: Chronic hyperin-sulinemia and blood pressure. Interaction with catecholamines? Hypertension 1990;15:519-527.