The Effects of Formulation Variables on the Stability of Freeze-Dried Human Growth Hormone

Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists

Volumn 8, Issue 4, 1991, Pages 427-436

  Pikal, Michael J ^a   Dellerman, Karen M ^a   Roy, Michael L ^a   Riggin, Ralph M ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

freeze drying; human growth hormone (hGH); lyoprotectants; protein formulation; stability of proteins

Indexed keywords

GROWTH HORMONE;

ARTICLE; DRUG DEGRADATION; DRUG FORMULATION; DRUG STABILITY; FREEZE DRYING;

BUFFERS; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; DRUG STABILITY; EXCIPIENTS; FREEZE DRYING; GROWTH HORMONE; HYDROGEN-ION CONCENTRATION; PHOSPHATES; SODIUM CHLORIDE; STRESS, MECHANICAL;

EID: 0025793265     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1023/A:1015834724528     Document Type: Article

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