Ebselen prevents inositol (1,4,5)-trisphosphate binding to its receptor

Biochemical Pharmacology

Volumn 42, Issue 5, 1991, Pages 1151-1153

  Dimmeler, Stefanie ^a   Brüne, Bernhard ^a   Ullrich, Volker ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EBSELEN; INOSITOL 1,4,5 TRISPHOSPHATE;

ARTICLE; HUMAN; HUMAN CELL; MICROSOME; PRIORITY JOURNAL; RECEPTOR BINDING; THROMBOCYTE;

ANILIDES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AZOLES; BLOOD PLATELETS; CALCIUM; COMPARATIVE STUDY; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; FURA-2; HEPARIN; HUMAN; INOSITOL 1,4,5-TRISPHOSPHATE; MICROSOMES; PLATELET ACTIVATION; RECEPTORS, CELL SURFACE; SELENIUM; SULFHYDRYL COMPOUNDS; SUPPORT, NON-U.S. GOV'T;

EID: 0025789096     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(91)90303-M     Document Type: Article

References (14)

1. Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions
2. A novel biologically active seleno-organic compound-I Glutathion peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (ebselen)
3. Ebselen affects calcium homeostatis in human platelets
4. 2+ release from human platelets membranes
5. 2+ release activities of inositol 1,4,5-trisphosphate in bovine adrenal cortex
6. Solubilization, purification, and characterization of an inositol trisphosphate receptor
7. Mechanism of the reaction of ebselen with endogenous thiols: dihydrolipoate is a better cofactor than glutathion in the peroxidase activity of ebselen
8. Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C
9. Optical spectral studies of ebselen interaction with cytochrome P-450 of rat liver microsomes
10. Characterization of calcium liberation from human platelet membrane fraction
11. Are there subtypes of the inositol 1,4,5-trisphosphate receptor?
12. Changes in inositol 1,4,5-trisphosphate binding to hepatic plasma membranes caused by temperature, N-ethylmaleimide and menadione
13. Characterization of inositol trisphosphate receptor binding in brain
14. 2 release from sarcoplasmic reticulum via an oxidation reaction