Difference in the developmental toxicity of ethylenethiourea and three N,N′-substituted thiourea derivatives in rats

Toxicological Sciences

Volumn 17, Issue 2, 1991, Pages 399-408

  Saillenfait, A M ^a   Sabate, J P ^a   Langonne, I ^a   Ceaurriz, J De ^a  

^a Inst Natl de Rec et de Securite   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DIBUTYLTHIOUREA; 2 IMIDAZOLIDINETHIONE; DIMETHYLTHIOUREA; THIOCARBANILIDE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; EMBRYO; EMBRYOTOXICITY; FEMALE; FETOTOXICITY; FETUS; MALE; NONHUMAN; RAT; TERATOGENICITY;

ANIMAL; BEHAVIOR, ANIMAL; BODY WEIGHT; EMBRYO; ETHYLENETHIOUREA; FEMALE; GESTATIONAL AGE; INTUBATION, GASTROINTESTINAL; PREGNANCY; RATS; RATS, INBRED STRAINS; REPRODUCTION; TERATOGENS; THIOUREA;

ANIMALIA;

EID: 0025787261     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/17.2.399     Document Type: Article

References (11)

1. BARROW, M. W., AND TAYLOR, W. J. (1969). A rapid method for detecting malformations in rat fetuses. J. Morphol., 127, 291-306.
2. CHERNOFF, N., KAVLOCK, R. J., ROGERS, E. H., CARVER, B. D., AND MURRAY, S. (1979). Perinatal toxicity of maneb, ethylenethiourea, and ethylenebisisothiocyanate sulfide in rats. J. Toxicol. Environ. Health 5, 821-834.
3. KHERA, K. S. (1973). Ethylenethiourea: Teratogenicity study in rats and rabbits. Teratology 7, 243-252.
4. KHERA, K. S. (1987). Ethylenethiourea: A review of teratogenicity and distribution studies and an assessment of reproduction risk. CRC Crit. Rev. Toxicol., 18, 129-139.
5. KHERA, K. S., AND TRYPHONAS, L. (1977). Ethylenethiourea-induced hydrocephalus: Pre- and postnatal pathogenesis in offspring from rats given a single oral dose during pregnancy. Toxicol. Appt. Pharmacol., 42, 85-97.
6. KORHONEN, A., HEMMINKI, K., AND VAINIO, H. (1982). Embryotoxicity of industrial chemicals on the chicken embryo: Thiourea derivatives. Acta Pharmacol. Toxicol., 51, 38-44.
7. Office of Toxic Substances, U.S. Environmental Protection Agency (EPA) (1981). Chemical Hazard Information Profile, Draft Report, N, N’-dimethylthiourea, CAS № 534-13-4.
8. RUDDICK, J. A., AND KHERA, K, S. (1975). Pattern of anomalies following single oral doses of ethylenethiourea to pregnant rats. Teratology 12, 277-282.
9. RUDDICK, J. A., NEWSOME, W. H., AND NASH, L. (1976). Correlation of teratogenicity and molecular structure: Ethylenethiourea and related compounds. Teratology 13, 263-266.
10. TERAMOTO, S., KANEDA, M., AOYAMA, H., AND SHIRASU, Y. (1981). Correlation between the molecular structure of N-alkylureas and N-alkylthioureas and their teratogenic properties. Teratology 23, 335-342.
11. TERAMOTO, S., SHINGU, A., KANEDA, M., AND SATTO, R. (1978). Teratogenicity studies with ethylenethiourea in rats, mice and hamsters. Cortgen. Anomalies 18, 11-17.