Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: An FAD- and FMN-containing flavoprotein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 88, Issue 17, 1991, Pages 7773-7777

  Stuehr, Dennis J ^a,b   Cho, Hearn J ^a   Kwon, Nyoun Soo ^a,c   Weise, Mary F ^a   Nathan, Carl F ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c Chung Ang University College of Medicine   (South Korea)

Author keywords

Endothelium derived relaxing factor; Interferon ; L arginine

Indexed keywords

BACTERIA (MICROORGANISMS); EUKARYOTA;

CYTOKINE; ENDOTHELIUM DERIVED RELAXING FACTOR; FLAVOPROTEIN; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ARTICLE; ENZYME KINETICS; ENZYME PURIFICATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID OXIDOREDUCTASES; ANIMAL; CALCIUM; CALMODULIN; CELL LINE; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; CYTOKINES; ENZYME INDUCTION; ESCHERICHIA COLI; FLAVIN MONONUCLEOTIDE; FLAVIN-ADENINE DINUCLEOTIDE; INTERFERON TYPE II; KINETICS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MOLECULAR WEIGHT; NITRIC-OXIDE SYNTHASE; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0025787205     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.88.17.7773     Document Type: Article

References (35)

1. Ignarro, L. J. (1990) Annu. Rev. Pharmacol. Toxicol. 30, 535-560.
2. Hibbs, J. B., Jr., Taintor, R. R., Vavrin, Z., Granger, D. L., Drapier, J. C., Amber, I. J. & Lancaster, J. R. (1990) in Nitric Oxide from L-Arginine: A Bioregulatory System, eds. Moncada, S. & Higgs, E. A. (Elsevier, New York), pp. 189-223.
3. Nathan, C. F. & Hibbs, J. B., Jr. (1991) in Current Opinion in Immunology, eds. Silverstein, S. & Unkeless, J. (Current Science, London), Vol. 3, pp. 65-70.
4. Bredt, D. S. & Snyder, S. H. (1990) Proc. Natl. Acad. Sci. USA 87, 682-685.
5. Schmidt, H. H. H. W., Pollock, J. S., Nakane, M., Gorsky, L. D., Forstermann, U. & Murad, F. (1991) Proc. Natl. Acad. Sci. USA 88, 365-369.
6. Mayer, B., John, M. & Bohme, E. (1991) FEBS Lett. 277, 215-219.
7. Yui, Y., Hattori, R., Kosuga, K., Eizawa, H., Hiki, K., Ohkawa, S., Ohnishi, K., Terao, S. & Kawai, C. (1991) J. Biol. Chem. 266, 3369-3371.
8. Stuehr, D. J. & Marletta, M. A. (1987) J. Immunol. 139, 518-525.
9. Drapier, J. C. & Hibbs, J. B., Jr. (1988) J. Immunol. 140, 2829-2838.
10. Ding, A., Nathan, C. F. & Stuehr, D. J. (1988) J. Immunol. 141, 2407-2412.
11. Kilbourn, R. G., Gross, S. S., Jubran, A., Adams, J., Griffith, O. W., Levi, R. & Lodato, R. F. (1990) Proc. Natl. Acad. Sci. USA 87, 3628-3632.
12. Kilbourn, R. G., Jubran, A., Gross, S. S., Griffith, O. W., Levi, R., Adams, J. & Lodato, R. F. (1990) Biochem. Biophys. Res. Commun. 172, 1132-1138.
13. Bredt, D. S., Hwang, P. M. & Snyder, S. H. (1990) Nature (London) 347, 768-770.
14. Kwon, N. S., Nathan, C. F. & Stuehr, D. J. (1989) J. Biol. Chem. 264, 20496-20501.
15. Tayeh, M. A. & Marietta, M. A. (1989) J. Biol. Chem. 264, 19654-19658.
16. Kwon, N. S., Nathan, C. F., Gilker, C., Griffith, O. W., Matthews, D. E. & Stuehr, D. J. (1990) J. Biol. Chem. 265, 13442-13445.
17. Stuehr, D. J., Kwon, N. S. & Nathan, C. F. (1990) Biochem. Biophys. Res. Commun. 168, 558-565.
18. Stuehr, D. J., Fasehun, O. A., Kwon, N. S., Gross, S. S., Gonzalez, J. A., Levi, R. & Nathan, C. F. (1991) FASEB J. 5, 98-103.
19. Stuehr, D. J. & Griffith, O. W. (1991) Adv. Enzymol. Relat. Areas Mol. Biol., in press.
20. Feelisch, M. & Noak, E. A. (1987) Eur. J. Pharmacol. 139, 19-30.
21. Stuehr, D. J., Kwon, N. S., Nathan, C. F., Griffith, O. W., Feldman, P. L. & Wiseman, J. (1991) J. Biol. Chem. 266, 6259-6263.
22. Gnanaiah, W. & Omdahl, J. L. (1986) J. Biol. Chem. 261, 12649-12654.
23. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254.
24. Stuehr, D. J., Kwon, N. S., Gross, S. S., Thiel, B. A., Levi, R. & Nathan, C. F. (1989) Biochem. Biophys. Res. Commun. 161, 420-426.
25. Billiar, T. R., Curran, R. D., Stuehr, D. J., Stadler, J., Simmons, R. L. & Murray, S. A. (1990) Biochem. Biophys. Res. Commun. 168, 1034-1040.
26. Kilbourn, R. G. & Belloni, P. (1990) J. Natl. Cancer Inst. 82, 772-776.
27. Werner-Felmayer, G., Werner, E. R., Fuchs, D., Hausen, A., Reibnegger, G. & Wachter, H. (1990) J. Exp. Med. 172, 1599-1607.
28. Beasly, D., Schwartz, J. H. & Brenner, B. M. (1991) J. Clin. Invest. 87, 602-608.
29. Iyanagi, T. & Mason, H. S. (1973) Biochemistry 12, 2297-2308.
30. Vermilion, J. L., Ballou, D. P., Massey, V. & Coon, M. J. (1981) J. Biol. Chem. 256, 266-267.
31. Otvos, J. D., Krum, D. P. & Masters, B. S. S. (1986) Biochemistry 25, 7220-7228.
32. Narhi, L. O. & Fulco, A. J. (1986) J. Biol. Chem. 261, 7160-7169.
33. Ostrowski, J., Barber, M. J., Rueger, D. C., Miller, B. E., Siegel, L. M. & Kredich, N. M. (1989) J. Biol. Chem. 264, 15796-15808.
34. Remuzzi, G., Perico, N., Zoja, C., Corna, D., Macconi, D. & Vigano, G. (1990) J. Clin. Invest. 86, 1768-1771.
35. Southern, C., Schulster, D. & Green, I. C. (1990) FEBS Lett. 276, 42-44.