Subcellular characteristics of phospholipase A2 activity in the rat kidney: Enhanced cytosolic, mitochondrial, and microsomal phospholipase A2 enzymatic activity after renal ischemia and reperfusion

Journal of Clinical Investigation

Volumn 87, Issue 5, 1991, Pages 1810-1818

  Nakamura, Harumasa ^b   Nemenoff, Raphael A ^b   Gronich, Joseph H ^b   Bonventre, Joseph V ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NONE

Author keywords

Acute renal failure; Acyl hydrolases; Calcium; Fatty acids; Phospholipids

Indexed keywords

CALCIUM; KIDNEY ENZYME; PHOSPHOLIPASE A2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; KIDNEY ISCHEMIA; MALE; MICROSOME; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION;

ANIMAL; CALCIUM; CYTOSOL; ISCHEMIA; KIDNEY; MALE; MICROSOMES; MITOCHONDRIA; PHOSPHOLIPASES A; PHOSPHOLIPIDS; RATS; RATS, INBRED STRAINS; REPERFUSION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0025782547     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI115202     Document Type: Article

References (48)

1. Bonventre, J. V., A. Leaf, and C. D. Malis. 1988. Nature of the cellular insult in ischemic acute renal failure. In Acute Renal Failure. B. M. Brenner and J. M. Lazarus, editors. Churchill Livingstone, New York. 3-43.
2. 2 dependent release of fatty acids from peroxide membranes. J. Free Radicals Biol. Med. 1:263-271.
3. 2 in mitochondria enriched with n-3 fatty acids. Proc. Natl. Acad. Sci. USA. 87:8845-8849.
4. Chiariello, M., G. Ambrosio, M. Cappelli-Bigazzi, E. Nevola, P. PerroneFilardi, G. Marone, and M. Condorelli, 1987. Inhibition of ischemia-induced phospholipase activation by quinacrine protects jeopardized myocardium in rats with coronary artery occlusion. J. Pharmacol. Exp. Ther. 241:560-568.
5. 2 and oxygenated free radicals in mucosal damage after small intestinal ischemia and reperfusion. Am. J. Surg. 157:562-566.
6. Malis, M. D., and J. V. Bonventre. 1986. Mechanism of calcium potentiation of oxygen free radical injury to renal mitochondria. J. Biol. Chem. 261:14201-14208.
7. Nishida, T., H. Shibata, M. Koseki, K. Nakao, Y. Kawashima, Y. Yoshida, and K. Tagawa. 1987. Peroxidative injury of the mitochondrial respiratory chain during reperfusion of hypothermic rat liver. Biochim. Biophys. Acta. 890:82-88.
8. Spencer, V. L. 1976. Translocation and binding of adenine nucleotides by rat liver mitochondria depleted of phospholipids. Biochim. Biophys. Acta. 423:365-373.
9. 2-induced rabbit renal proximal tubule cell injury. J. Clin. Invest. 82:1098-1105.
10. Matthys, E., Y. Patel, J. Kreisberg, J. H. Stewart, and M. Venkatachalam. 1984. Lipid alterations induced by renal ischemia: pathogenic factor in membrane damage. Kidney Int. 26:153-161.
11. Bazan, N. G. 1970. Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain. Biochim. Biophys. Acta. 218:1-10.
12. 2 in cardiac membrane destabilization under calcium overload conditions. Basic Res. Cardiol. 79:668-678.
13. Bonventre, J. V., and R. A. Nemenoff. 1991. Renal tubular arachidonic acid metabolism. Kidney Int. 39:438-449.
14. 2 activity. Basic Res. Cardiol. 82:127-136.
15. Van der Vusse, G. J., M. Van Bilsen, and R. S. Reneman. 1989. Is phospholipid degradation a critical event in ischemia- and reperfusion-induced damage? Trends. Phys. Sci. 4:49-53.
16. 2 activity in the kidney of spontaneous hypertensive rats. Arch. Biochem. Biophys. 248:401-407.
17. 2 in rat renal mesangial cells. J Biol. Chem. 263:16645-16651.
18. Bonventre, J. V., K. L. Skorecki, J. I. Kreisberg, and J. Y. Cheung. 1986. Vasopressin increases cytosolic free calcium concentration in glomerular mesangial cells. Am. J. Physiol. 251:F94-102.
19. 2 from rat kidney activated at physiological calcium concentrations. Biochem. J. 271:37-43.
20. Bonventre, J. V., and J. Y. Cheung. 1986. Cytosolic free calcium concentration in cultured renal epithelial cells. Am. J. Physiol. (Renal Fluid Electrolyte Physiol. 19). 250:F329-F338.
21. Hansford, R. G., and F. Castro. 1982. Intramitochondrial and extramitochondrial free calcium concentrations of suspensions of heart mitochondria with very low, plausibly physiological, contents of total calcium. J. Bioeng. Biomembr. 14:361-376.
22. 2 from rat liver mitochondria. Biochemistry. 10:2377-83.
23. 2. J. Biol. Chem. 264:10008-10014.
24. 2 from rat spleen. J. Biol. Chem. 263:5732-5738.
25. 2 activity in platelets: immune-purification and localization of the enzyme in rat platelets. J. Lipid Mediators. 1:49-61.
26. 2. J. Clin. Invest. 82:168-176.
27. Steenbergen, C., E. Murphy, L. Levy, and R. E. London. 1987. Elevation in cytosolic free calcium concentration early in myocardial ischemia in perfused rat heart. Circ. Res. 60:700-707.
28. 19F NMR spectroscopy in intact ferret hearts. Proc. Natl. Acad. Sci. USA. 84:6005-6009.
29. Snowdowne, K. W., C. C. Freudenrich, and A. B. Borle. 1985. The effects of anoxia on cytosolic free calcium, calcium fluxes, and cellular ATP levels in cultured kidney cells. J. Biol. Chem. 260:14998-15007.
30. Mandel, L. J., T. Takano, S. P. Soltoff, W. R. Jacobs, A. LeFurgey, and P. Ingram. 1987. Multiple roles of calcium in anoxic-induced injury in renal proximal tubules. In Cell Calcium and the Control of Membrane Transport. L. J. Mandel and D. C. Eaton, editors. Rockefeller University Press, New York. 277-285.
31. Wan, B., K. F. LaNoue, J. Y. Cheung, and J. Scaduto. 1989. Regulation of citric acid cycle by calcium. J. Biol. Chem. 264:13430-13439.
32. Smith, M. W., Y. Collan, M. W. Kahnyg, and B. F. Trump. 1980. Changes in mitochondrial lipids of rat kidney during ischemia. Biochim. Biophys. Acta. 618:192-201.
33. Sen, A., J. C. Miller, R. Reynolds, J. T. Willerson, L. M. Buja, and K. R. Chien. 1988. Inhibition of the release of arachidonic acid prevents the development of sarcolemmal membrane defects in cultured rat myocardial cells during adenosine triphosphate depletion. J. Clin. Invest. 82:1333-1338.
34. 2 and decreased lysophospholipase activity in the small intestinal mucosa after ischemia and revascularisation. Gut. 28:1445-1453.
35. Chien, K. R., J. Abrams, A. Serroni, J. T. Martin, and J. L. Farber. 1978. Accelerated phospholipid degradation and associated membrane dysfunction in irreversible, ischemic liver cell injury. J. Biol. Chem. 253:4809-4817.
36. Das, D. K., R. M. Engleman, and J. A. Rousow. 1986. Role of membrane phospholipids in myocardial injury induced by ischemia and reperfusion. Am. J. Physiol. 251:H71-79.
37. Waite, M. 1987. The Phospholipases: Handbook of Lipid Research. Volume 5. D. J. Hanahan, editor. Plenum Press, New York. 332 pp.
38. 2 in brain during ischemia. J. Neurochem. 39:1111-1116.
39. Kawaguchi, H., and H. Yasuda. 1988. Prostacyclin biosynthesis and phospholipase activity in hypoxic rat myocardium. Circ. Res. 62:1175-1181.
40. 2 activity in vitro and demonstration of an endogenous inhibitor. Proc. Natl. Acad. Sci. USA. 80:5203-5207.
41. 2 activity by unsaturated fatty acids. Proc. Natl. Acad. Sci. USA. 82:371-375.
42. Okayasu, T., M. T. Curtis, and J. L. Farber. 1985. Structural alterations of the inner mitochondrial membrane in ischemic liver cell injury. Arch. Biochem. Biophys. 236:638-645.
43. 2+ plus N-ethyl-maleimide on mitochondrial function. J. Biol. Chem. 254:11485-11494.
44. Trump, B. F., W. J. Mergner, and M. W. Kahng. 1976. Studies on the subcellular pathophysiology of ischemia. Circulation. 53:117-126.
45. Bonventre, J. V., and J. Y. Cheung. 1985. Effects of metabolic acidosis on viability of cells exposed to anoxia. Am. J. Physiol. (Cell Physiol. 18). 249:C149-C159.
46. 3H] phorbol 12, 13-dibutyrate. Brain Res. 481:1-7.
47. Louis, J.-C., E. Magal, and E. Yavin. 1988. Protein kinase C alterations in the fetal rat brain after global ischemia. J. Biol. Chem. 263:19282-19285.
48. 2 protein indistinguish