Reaction mechanism of alkaline phosphatase based on crystal structures. Two-metal ion catalysis

Journal of Molecular Biology

Volumn 218, Issue 2, 1991, Pages 449-464

  Kim, Eunice E ^a   Wyckoff, Harold W ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; METAL ION;

ARTICLE; CRYSTAL STRUCTURE; ENZYME MECHANISM; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL;

ALKALINE PHOSPHATASE; AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; ESCHERICHIA COLI; HYDROGEN BONDING; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHATES; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; X-RAY DIFFRACTION; ZINC;

ESCHERICHIA COLI;

EID: 0025777694     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-2836(91)90724-K     Document Type: Article

References (72)

1. Cobalt(III)-promoted hydrolysis of a phosphate ester
2. Phosphate binding to alkaline phosphatase
3. Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.
4. The protein data bank: A computer-based archival file for macromolecular structures
5. Phosphate binding to Escherichia coli alkaline phosphatase
6. The phosphate content of Escherichia coli alkaline phosphatase and its effect on stopped flow kinetic studies
7. Effect of magnesium on the properties of zinc alkaline phosphatase
8. Amino acid sequence of Escherichia coli alkaline phosphatase
9. Crystallographic R-factor refinement by molecular dynamics
10. Slow-cooling protocols for crystallographic refinement by simulated annealing
11. Stereochemistry of phospho group transfer catalyzed by a mutant alkaline phosphatase
12. Use of site-directed mutagenesis to elucidate the role of arginine-166 in the catalytic mechanism of alkaline phosphatase
13. Structural aspects of metal ion-carboxylate interaction
14. Function of arginine-166 in the active site of Escherichia coli alkaline phosphatase
15. Nucleotide sequence of the alkaline phosphatase gene of Escherichia coli
16. Presteady state kinetics of phosphorothioate hydrolysis by alkaline phosphatase
17. Mechanisms of hydrolysis of O-phosphorothioates and inorganic thiophosphate by Escherichia coli alkaline phosphatase
18. Metallophosphoryl and apophosphoryl alkaline phosphatases
19. 31P NMR of phosphate and phosphonate complexes of metalloalkaline phosphatases
20. 113Cd NMR
21. Is zinc-hydroxide a required species in the mechanism of action on zinc enzymes
22. Multinuclear nuclear magnetic resonance approaches to the structure and mechanism of alkaline phosphatase
23. Molecular properties and mechanism of alkaline phosphatase
24. Alkaline phosphatase, solution structure and mechanism
25. Structure of bis(methylguanidinium) monohydrogen orthophosphate. A model for the arginine-phosphate interactions at the active site of Staphylococcal nuclease and other phosphohydrolytic enzymes
26. The phosphorylation of Tris by alkaline phosphatase
27. Crystal structure studies of calcium complexes and implications for biological systems
28. Mammalian alkaline phosphatases
29. Divalent metal ion catalysis in hydrolysis of phosphomonoesters. Hydrolysis of 2-(l,10-phenanthrolyl) phosphate
30. Incorporation of fast Fourier transforms to speed restrained least-squares refinement of protein structures
31. Cocrystal structure of an editing complex of Klenow fragment with DNA
32. Crystal Structure of Propylguanidinium Diethyl Phosphate.
33. Oxygen chiral phosphate esters
34. 113Cd nuclear magnetic resonance of Cd(II) alkaline phosphatases
35. 31P nuclear magnetic resonance of phosphoenzyme intermediates of alkaline phosphatase
36. 31P NMR probes of the mechanism
37. Manganese and calcium binding sites of concanavalin A
38. 2 (M = Ca, Mg)
39. Metal ion promoted phosphate ester hydrolysis. Intramolecular attack of coordinated hydroxide ion
40. The effect of divalent metal ions on the rate and transition-state structure of phosphoryl-transfer reactions
41. Structure of thermolysin refined at 1.6 Å resolution
42. High-resolution (1.5 Å) crystal structure of phospholipase C from Bacillus cereus
43. Bacillus subtilis alkaline phosphatases III and IV: cloning, sequencing and comparisons of deduced amino acid sequence with Escherichia coli alkaline phosphatase 3-D structure
44. 31P nuclear magnetic resonance study of alkaline phosphatase: The role of inorganic phosphate in limiting the enzyme turnover rate at alkaline pH
45. 18O]stereochemical course of alkaline phosphatase
46. A graphics model building and refinement system for macromolecules
47. FRODO: A graphics fitting program and refinement system for macromolecules
48. Structural characteristics of the PH08 gene encoding repressible alkaline phosphatase in Saccharomyces cerevisiae
49. Structure of alkaline phosphatases
50. 20
51. Enzyme-catalyzed phosphoryl transfer reactions
52. The interpretation of protein structures: Estimation of static accessibility
53. Aspartatic acid-484 of nascent placental alkaline phosphatase condenses with a phosphatidylinositol glycan to become the carboxyl terminus of the mature enyme
54. Characterization of the properties of the multiple metal binding sites in alkaline phosphatase by carbon-13 nuclear magnetic resonance
55. Determination by cadmium-113 nuclear magnetic resonance of the structural basis for metal ion dependent anticooperativity in alkaline phosphatase
56. Characterization of the histidine residues in alkaline phosphatase by carbon-13 nuclear magnetic resonance
57. Alkaline phosphatase of Escherichia coli: A zinc metalloenzyme
58. RIBBON: a stereo cartoon drawing program for proteins
59. E. coli alkaline phosphatase
60. Determination of the tautomeric form of the imidazole ring of l-histidine in basic solution by carbon-13 magnetic resonance spectroscopy
61. Molecular analysis of the gene encoding alkaline phosphatase in Streptococcus faecalis 10C1
62. Specific interactions involving guanidyl group observed in crystal structures
63. n
64. Refined structure of alkaline phosphatase from Escherichia coli at 2.8 Å resolution
65. Die Entwicklung und Anwendung von Rechenverfahren und Rechenprogrammen zur Strukturanalyse von Proteiner am Beispiel des Trypsininhibitor Komplexes, des freien Inhibitors und der l-Asparaginase
66. Nitrogen Ligands at the Active Site of Alkaline Phosphatase
67. A missense mutation in the human liver/bone/kidney alkaline phosphatase gene causing a lethal form of hypophosphatasia
68. Alkaline phosphatase: physiological role explored in hypophosphatasia
69. Some properties of alkaline phosphatase from Escherichia coli. Transphosphorylation
70. Structure of Escherichia coli alkaline phosphatase determined by X-ray diffraction
71. The three dimensional structure of alkaline phosphatase from E. coli