Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death

Cell

Volumn 65, Issue 7, 1991, Pages 1107-1115

  Henderson, Sheila ^a   Rowe, Martin ^a   Gregory, Chris ^a   Croom Carter, Debbie ^a   Wang, Fred ^b   Longnecker, Richard ^b   Kieff, Elliott ^b   Rickinson, Alan ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN HERPESVIRUS 4;

MEMBRANE PROTEIN; VIRUS PROTEIN;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; EPSTEIN BARR VIRUS; GENE EXPRESSION; HUMAN; HUMAN CELL; ONCOGENE; PRIORITY JOURNAL; VIRUS INFECTION;

ANTIGENS, VIRAL; B-LYMPHOCYTES; CELL LINE; CELL SURVIVAL; DNA DAMAGE; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 4, HUMAN; HUMAN; IN VITRO; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SUPPORT, NON-U.S. GOV'T; TRANSFECTION;

EID: 0025772343     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(91)90007-L     Document Type: Article

References (50)

1. H on chromosome 14 and near a transcriptional unit on 18
2. fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection
3. The bcl-2 candidate proto-oncogene product is a 24 kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14:18) translocation
4. Nucleotide sequence of a t(14;18) chromosomal breakpont in follicular lymphoma and demonstration of a breakpoint cluster region near a transcriptionally active locus on chromosome 18
5. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation
6. Epstein-Barr virus latent membrane protein inhibits human epithelial cell differentiation
7. Death and the cell
8. Morphological transformation of human keratinocytes expressing the LMP gene of Epstein-Barr virus
9. Eradication of Epstein-Barr virus by allogeneic bone marrow transplantation: implications for sites of viral latency
10. Down regulation of cell adhesion molecules LFA-3 and ICAM-1 in Epstein-Barr virus-positive Burkitt's lymphoma underlies tumour cell escape from virus-specific T cell surveillance
11. Different Epstein-Barr virus (EBV) B cell interactions in phenotypically distinct clones of a Burkitt lymphoma cell line
12. Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis
13. The virus as the etiologic agent of infectious mononucleosis
14. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
15. Epstein-Barr virus and its replication
16. Mechanism of antigen-driven selection in germinal centres
17. A second Epstein-Barr virus membrane protein (LMP 2) is expressed in latent infection and colocalizes with LMP 1
18. Antigen-driven selection of virgin and memory B cells
19. The pathogenesis of Burkitt's lymphoma
20. 2+-mediated endonuclease activation
21. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
22. The establishment of lymphoblastoid cell lines from adult and from foetal human lymphoid tissue and its dependence on EBV
23. Growth- and tumor-promoting effects of deregulated BCL2 in human B lymphoblastoid cells
24. De-regulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines
25. Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation
26. Regulation of bcl-2 proto-oncogene expression during normal human lymphocyte proliferation
27. De-regulated BCL2 expression enhances growth of a human B cell line
28. Endemic Burkitt's lymphoma: phenotypic analysis of Burkitt's lymphoma biopsy cells and of the derived tumour cell lines
29. Distinctions between endemic and sporadic forms of Epstein-Barr virus-positive Burkitt's lymphoma
30. Epstein-Barr virus status and tumour cell phenotype in sporadic Burkitt's lymphoma
31. Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells
32. Monoclonal antibodies to the latent membrane protein of Epstein-Barr virus reveal heterogeneity of the protein and inducible expression in virus-transformed cells
33. Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man
34. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures
35. Novel primitive lymphoid tumours induced in transgenic mice by co-operation between myc and bcl-2
36. Early events in Epstein-Barr virus infection provide a model for B cell activation
37. Overexpression of the human BCL-2 gene product results in growth enhancement of Epstein-Barr virus-immmortalized B cells
38. Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphomas
39. Cloning of the chromosome breakpoint of the neoplastic B cells with the t(14;18) chromosome translocation
40. Bcl-2 gene promotes haemopoietic cell survival and co-operatives with v-myc to immortalise pre-B cells
41. An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells
42. Epstein-Barr virus latent infection membrane protein (LMP) alters human B lymphocyte phenotype: deletion of the amino terminus abolishes activity
43. Epstein-Barr virus nuclear antigen 2 specifically induces expression of the B cell activation antigen CD23
44. Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23
45. Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis
46. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
47. Chromatin cleavage in apoptosis, association with condensed chromatin morphology and dependence on macromolecular synthesis
48. Epstein-Barr virus-infected B cells persist in the circulation of acyclovir-treated virus carriers
49. A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently-infected cells
50. Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease